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Increased levels of hepatic and renal metallothionein in the rat and guinea pig after percutaneous application of zinc chloride

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References

  1. Brzeznicka EA, Lehman LD, Klaassen CD (1987) Induction of hepatic metallothionein following administration of urethane. Toxicol Appl Pharmacol 87:457–463

    PubMed  Google Scholar 

  2. Chen RW, Ganther HE (1975) Relative cadmium-binding capacity of metallothionein and other fractions in various tissues of the rat. Environ Physiol Biochem 5:378–388

    PubMed  Google Scholar 

  3. Cherian MG, Goyer RA (1978) Metallothioneins and their role in the metabolism and toxicity of metals. Life Sci 23:1–10.

    PubMed  Google Scholar 

  4. Dunn MA, Lynn Blalock T, Cousins RJ (1987) Metallothionein. Proc Soc Exp Biol Med 185:107–119

    PubMed  Google Scholar 

  5. Eaton DL, Stacey NH, Wong KL, Klaassen CD (1980) Dose-response effects of various metal ions on rat liver metallothionein, glutathion, heme oxidase, and cytochrome P-450. Toxicol Appl Phamacol 55:393–402

    Google Scholar 

  6. Eaton DL, Toal BF (1982) Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66:134–142

    PubMed  Google Scholar 

  7. Goering PL, Tandon SK, Klaassen CD (1985) Induction of hepatic metallothionein in mouse liver following administration of chelating agents. Toxicol Appl Pharmacol 80:467–472

    PubMed  Google Scholar 

  8. Hart BA (1986) Cellular and biochemical response of the rat lung to repeated inhalation of cadmium. Toxicol Appl Pharmacol 82: 281–291

    PubMed  Google Scholar 

  9. Hart BA, Cherian MG, Angel A (1985) Cellular localization of metallothionein in the lung following repeated cadmium inhalation. Toxicology 37:171–179

    PubMed  Google Scholar 

  10. Heilmaier HE, Summer KH (1985) Metallothionein content and zinc status in various tissues of rats treated with iodoacetic acid and zinc. Arch Toxicol 56:247–251

    PubMed  Google Scholar 

  11. Klaassen CD (1981) Induction of metallothionein by adrenocortical steroids. Toxicology 20:275–279

    PubMed  Google Scholar 

  12. Maitani T, Suzuki KT (1982) Extents of hepatic zinc-thionein induction in mice given equimolar dose of various heavy metals. Chem Pharm Bull 30:4164–4169

    PubMed  Google Scholar 

  13. Mogilnicka EA, Piotrowski JK, Trojanowska B (1975) Effect of some metals (Cd, Hg, Zn, Cu, Pb, Mn, V) on metallothionein level in the liver and kidney of the rat. Med Pr 26:147–155

    Google Scholar 

  14. Onosaka S, Cherian MG (1981) The induced synthesis of metallothionein in various tissues of rat in response to metals. I. Effect of repeated injections of cadmium salts. Toxicology 22:91–101

    PubMed  Google Scholar 

  15. Onosaka S, Tanaka K, Doi M, Okahara K (1978) A simplified procedure for determination of metallothionein in animal tissues. Eisei Kagaku 24:128–133

    Google Scholar 

  16. Waalkes MP, Klaassen CD (1985) Concentration of metallothionein in major organs of rats after administration of various metals. Fund Appl Toxicol 5:473–477

    Google Scholar 

  17. Wahlberg JE (1965) Percutaneous toxicity of metal compounds. Arch Environ Health 11:201–204

    PubMed  Google Scholar 

  18. Wormser U, Calp D (1988a) Metallothionein induction by cadmium and zinc in rat secretory organs. Experientia 44:754–755

    PubMed  Google Scholar 

  19. Wormser U, Calp D (1988b) Increased levels of hepatic metallothionein in rat and mouse after injection of acetaminophen. Toxicology 53:323–329

    PubMed  Google Scholar 

  20. Zelazowski AJ, Piotrowski JK (1977) The level of metallothionein like proteins in animal tissues. Experientia 33: 1624–1625

    PubMed  Google Scholar 

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Wormser, U., BenZakine, S. Increased levels of hepatic and renal metallothionein in the rat and guinea pig after percutaneous application of zinc chloride. Bull. Environ. Contam. Toxicol. 46, 249–254 (1991). https://doi.org/10.1007/BF01691945

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Keywords

  • Chloride
  • Zinc
  • Waste Water
  • Water Management
  • Water Pollution