Abstract
The in vitro activity of the new naphthyridone trovafloxacin (CP 99,219) was compared with those of penicillin G and six other agents (cefpodoxime, erythromycin, azithromycin, clindamycin, ciprofloxacin, and sparfloxacin) against 316 penicillin-susceptible and -resistant pneumococci isolated in the former Czechoslovakia. Trovafloxacin was very active against strains ofStreptococcus pneumoniae (MIC50 and MIC90 0.25 Μg/ml). Ciprofloxacin was less active (MIC50 1.0 Μg/ml, MIC90 2.0 (Μg/ml), and MICs of sparfloxacin were between those of trovafloxacin and ciprofloxacin (MIC50 and MIC90 both 0.5 Μg/ml). MICs of cefpodoxime, erythromycin, azithromycin, and clindamycin were higher for strains intermediately resistant or resistant to penicillin than for penicillin-susceptible strains.
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Urbášková, P., Trupl, J., Hupková, H. et al. In vitro susceptibility of pneumococci to trovafloxacin, penicillin G, and other antimicrobial agents in the Czech Republic and Slovakia. Eur. J. Clin. Microbiol. Infect. Dis. 15, 686–688 (1996). https://doi.org/10.1007/BF01691161
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DOI: https://doi.org/10.1007/BF01691161