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Opportunistic fusarial infections in humans

European Journal of Clinical Microbiology and Infectious Diseases volume 14, pages 741–754 (1995)Cite this article

Abstract

Fusarium species are common hyaline soil saprophytes and plant pathogens which have frequently been reported as etiologic agents of opportunistic infections in humans. These infections have usually been limited to superficial mycoses, but recently the number of infections of deep tissues and disseminated infections has greatly increased, especially in patients with an underlying immunosuppressive condition. The characteristic signs of these infections are disseminated skin nodules, fungemia and multiorgan involvement. Frequently, myalgia is also present. Skin involvement occurred in over 80 % of cases of disseminated infections. These lesions are significant because they are readily accessible for biopsy and culture, thus permitting an early diagnosis. The therapy and outcome are dependent on the degree of invasion of the organisms and the status of the host. Identification of the pathogen to genus level is not difficult, but identification to species level requires a greater degree of expertise. Up to now, 15 species ofFusarium have been reported to cause infections in humans and animals. Few patients with disseminated fusarial infections have survived, even after receiving an adequate dosage of amphotericin B, the only antifungal agent that has some effect against these fungi. In vitro susceptibility to amphotericin B is a poor predictor of the clinical outcome of invasive fungal infections. Recovery of the phagocytic mechanisms in the form of rising neutrophil counts appears to be mandatory for clinical resolution. The resolution of neutropenia may be aided by the use of exogenous growth factors. Outside the USA, the majority of cases of disseminated fusarial infection have been reported from Mediterranean or tropical countries.

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References

  1. Guarro J, Gené J: Fusarium infections. Criteria for the identification of the responsible species. Mycoses 1992, 35: 109–114.

    PubMed  Google Scholar 

  2. Pascoe IG:Fusarium morphology I: identification and characterization of a third conidial type, the mesoconidia. Mycotaxon 1990, 37: 121–160.

    Google Scholar 

  3. Nirenberg HI: Recent advances in the taxonomy ofFusarium. Studies in Mycology 1990, 32: 91–101.

    Google Scholar 

  4. Piontelli E, Toro AM: Micromorfología de algunas especies deFusarium en PDA modificado III. Boletín Micológico 1992, 7: 85–91.

    Google Scholar 

  5. Gerlach W, Nirenberg HI: The genusFusarium — a pictorial atlas. Mitteilungen aus der Biologischen Bundesanstalt für Land- und Forstwirtschaft Berlin-Dahlem 1982, 209: 1–406.

    Google Scholar 

  6. Nelson PE, Tousson TA, Marassas WFO:Fusarium species, an illustrated manual for identification. Pennsylvania State University Press, University Park, PA, 1983, p. 193.

    Google Scholar 

  7. Gams W, Nirenberg HI: A contribution to the generic definitions ofFusarium. Mycotaxon 1989, 35: 407–416.

    Google Scholar 

  8. Nirenberg HI: Untersuchungen über die morphologische und biologische Differenzierung in derFusarium-Sektion Liseola. Mitteilungen aus der Biologischen Bundesanstalt für Land- und Forstwirtschaft Berlin-Dahlem 1976, 169: 1–117.

    Google Scholar 

  9. Fisher NL, Burgess TA, Tousson TA, Nelson PE: Carnation leaves as a substrate and for preserving cultures ofFusarium species. Phytopathology 1982, 72: 151–153.

    Google Scholar 

  10. Manicom BQ, Bar-Joseph M, Rosner A, Vigodsky-Haas H, Kotzé JM: Potential applications of random DNA probes and restriction fragment length polymorphisms in the taxonomy of the fusaria. Phytopathology 1987, 77: 669–672.

    Google Scholar 

  11. Manicom BQ, Bar-Joseph M, Kotzé JM: Molecular methods of potential use in the identification and taxonomy of filamentous fungi, particularlyFusarium oxysporum. Phytophylactica 1990, 22: 233–239.

    Google Scholar 

  12. Lodolo EJ, Van Zyl WH, Rabie CJ: A rapid molecular technique to distinguishFusarium species. Mycological Research 1992, 97: 345–346.

    Google Scholar 

  13. O'Donnell K:Fusarium and its near relations. In: Reynolds DE, Taylor JW (ed): The fungal holomorph: mitotic, meicotic and pleomorphic speciation in fungal systematics. CAB International, Wallingford, 1993, p. 225–233.

    Google Scholar 

  14. Thomas V, Rutherford MA, Bridge PD: Molecular differentiation of two races ofFusarium oxysporum special form cubense. Letters in Applied Microbiology 1994, 18: 193–196.

    Google Scholar 

  15. Wasfy EH, Bridge PD, Brayford D: Preliminary studies on the use of biochemical and physiological tests for the characterization ofFusarium isolates. Mycopathologia 1987, 99: 9–13.

    Google Scholar 

  16. Foster CS: Fungal keratitis. Infectious Disease Clinics of North America 1992, 6: 851–857.

    PubMed  Google Scholar 

  17. Richardson MD, Warnock DW: Fungal infection: diagnosis and management. Blackwell Scientific Publications, Oxford, 1993, p. 207.

    Google Scholar 

  18. Thomas PA: Mycotic keratitis — an underestimated mycosis. Journal of Medical and Veterinary Mycology 1994, 32: 235–236.

    PubMed  Google Scholar 

  19. Palacio A del, Gutiérrez A, Gutiérrez E: Ulcera corneal porFusarium solani. Revista Iberoamericana de Micología 1985, 2: 29–35.

    Google Scholar 

  20. Zapater RC: Opportunistic fungus infection,Fusarium infections (keratomycosis byFusarium). Japanese Journal of Medical Mycology 1986, 27: 68–69.

    Google Scholar 

  21. Gugnani HC, Gupta S, Talwar RS: Role of opportunistic fungi in ocular infections in Nigeria. Mycopathologia 1978, 65: 155–166.

    PubMed  Google Scholar 

  22. Matsumoto T, Soejima N: Keratomycoses. Mykosen 1976, 19: 217–222.

    PubMed  Google Scholar 

  23. Torres MA, Mohamed J, Cavazos-Adame H, Martínez LA: Topical ketoconazole for fungal keratitis. American Journal of Ophthalmology 1985, 100: 293–298.

    PubMed  Google Scholar 

  24. Wihelmus KR: Review of clinical experience with microbiol keratitis associated with contact lenses. Contact Lens Association of Ophthalmologists Journal 1987, 13: 211.

    Google Scholar 

  25. Strelow SA, Kent HD, Eagle RC, Colsen EJ: A case of contact lens relatedFusarium solani keratitis. Contact Lens Association of Ophthalmologists Journal 1992, 18: 125–127.

    Google Scholar 

  26. Vajpayee RB, Gupta SK, Bareja IJ, Kishore K: Ocular atopy and mycotic keratitis. Annals of Ophthalmology 1990, 22: 369–372.

    PubMed  Google Scholar 

  27. Kuriakose T, Thomas PA: Keratomycotic malignant glaucoma. Indian Journal of Ophthalmology 1991, 39: 118–121.

    PubMed  Google Scholar 

  28. Jones BR, Jones DB, Lim ASM, Bron AJ, Morgan G, Clayton YM: Corneal and intraocular infection due toFusarium solani. Transactions of the Ophthalmological Society of the United Kingdom 1969a, 89: 757.

    Google Scholar 

  29. Jones BR, Richard AB, Morgan G: Direct fungal infection of the eye in Britain. Transactions of the Ophthalmological Society of the United Kingdom 1969b, 89: 727.

    Google Scholar 

  30. Zaias N: Superficial white onychomycosis. Sabouraudia 1966, 5: 99–103.

    PubMed  Google Scholar 

  31. Rush-Munro FM, Black H, Dingley JM: Onychomycosis caused byFusarium oxysporum. Australasian Journal of Dermatology 1971, 12: 18–29.

    PubMed  Google Scholar 

  32. DiSalvo A, Fickling M: A case of nondermatophytic toe onychomycosis caused byFusarium oxysporum. Archives of Dermatology 1980, 6: 699–700.

    Google Scholar 

  33. Collins MS, Rinaldi MG: Cutaneous infection in man caused byFusarium moniliforme. Sabouraudia 1977, 15: 151–160.

    PubMed  Google Scholar 

  34. Balaguer-Meler J, Torres-Rodríguez JM: Intertrigo interdigitaux parFusarium solani. Bulletin de la Société Française de Mycologie Médicale 1984, 13: 201–204.

    Google Scholar 

  35. Ellis ME, Clink H, Younge D: Successful combined surgical and medical treatment ofFusarium infection after bone marrow transplantation. Scandinavian Journal of Infectious Diseases 1994, 26: 225–228.

    PubMed  Google Scholar 

  36. English MP: Invasion of skin by filamentous non dermatophyte fungi. British Journal of Dermatology 1968, 80: 282–286.

    PubMed  Google Scholar 

  37. English MP, Smith RJ, Harman RR: The fungal flora of ulcerated legs. British Journal of Dermatology 1971, 84: 567–581.

    PubMed  Google Scholar 

  38. Landau M, Srebrnik A, Worf R, Bashi E, Brenner S: Systemic ketoconazole treatment forFusarium leg ulcers. International Journal of Dermatology 1992, 31: 511–512.

    PubMed  Google Scholar 

  39. Peterson JE, Baker TJ: An isolate ofFusarium roseum from human burns. Mycologia 1959, 51: 453–456.

    Google Scholar 

  40. Holzegel K, Kempf HJ:Fusarium mycosis of the skin of a burned patient. Dermatologische Monatsschrift 1964, 150: 651.

    Google Scholar 

  41. Whesler MS, McGinnis MR, Schell WA, Walker OH:Fusarium infections in burned patients. Journal of Medical and Veterinary Mycology 1982, 25: 177–186.

    Google Scholar 

  42. Wadhwani K, Srivastava AK: Fungi from otitis media of agricultural field workers. Mycopathologia 1984, 88: 155–159.

    PubMed  Google Scholar 

  43. Jones DB: Pathogenesis of bacterial and fungal keratitis. Transactions of the Opthalmological Society of the United Kingdom 1978, 98: 367–371.

    Google Scholar 

  44. Patel AS, Hemady RK, Rodríguez M, Rajagopalan S, Elman MJ: EndogenousFusarium endophthalmitis in a patient with acute lymphocytic leukemia. American Journal of Ophthalmology 1994, 117: 363–368.

    PubMed  Google Scholar 

  45. Mohr JA, Nichols NB, Jones JH, Cherry P, Shaver RP: Fungal endophthalmitis. Southern Medical Journal 1980, 66: 685–688.

    Google Scholar 

  46. Forster RK, Zachary IG, Cottingham AJ, Norton EWD: Further observations on the diagnosis, cause and treatment of endophthalmitis. American Journal of Ophthalmology 1976, 81: 52–56.

    PubMed  Google Scholar 

  47. Rowsey JJ, Acers TE, Smith DL, Mohr JA, Newson DL, Rodriguez J:Fusarium oxysporum endophthalmitis. Archives of Ophthalmology 1979, 97: 103–105.

    PubMed  Google Scholar 

  48. Guss RB, Koenig S, De la Palma W, Marx M, Kaufman HE: Endophthalmitis after penetrating keratoplasty. American Journal of Ophthalmology 1983, 95: 651–658.

    PubMed  Google Scholar 

  49. Pflugfelder SC, Flynn HW, Zwicksey TA, Forster RK, Tsiligianni A, Culbertson WW, Mandelbaum S: Exogenous fungal endophthalmitis. Ophthalmology 1988, 95: 19–30.

    PubMed  Google Scholar 

  50. Srdic N, Radulovic S, Nonkovic Z, Velimirovic S, Cvetkovic L, Viro I: Two cases of exogenous endophthalmitis due toFusarium moniliforme andPseudomonas species as associated aetiological agents. Mycoses 1993, 36: 441–444.

    PubMed  Google Scholar 

  51. Comhaire-Poutchinian Y, Berthe-Bonnet S, Grek V, Cremer V: Endophthalmitis due toFusarium. An uncommon cause. Bulletin de la Société Belge d'Ophtalmologie 1990, 239: 75–78.

    Google Scholar 

  52. Cho CT, Vats TS, Lowman JT, Brandsberg JW, Tosh FE:Fusarium solani infection during treatment for acute leukemia. Journal of Pediatrics 1973, 83: 1028–1031.

    PubMed  Google Scholar 

  53. Robertson MJ, Socinski MA, Soiffer RJ, Finberg RN, Wilson C, Anderson KC, Bosserman L, Sanz DN, Salkin IF, Ritz J: Successful treatment of disseminatedFusarium infections after autologous bone marrow transplantation for acute myeloid leukemia. Bone Marrow Transplant 1991, 8: 143.

    PubMed  Google Scholar 

  54. Lieberman TW, Ferry AP, Bottone EJ:Fusarium solani endophthalmitis without primary corneal involvement. American Journal of Ophthalmology 1979, 88: 764–766.

    PubMed  Google Scholar 

  55. Louie T, Elbaba F, Shulman M, Jimenezlucho V: Endogenous endophthalmitis due toFusarium. Case report and review. Clinical Infectious Diseases 1994, 18: 585–588.

    PubMed  Google Scholar 

  56. Venditti M, Micozzi A, Gentile G, Polonelli L, Morace G, Bianco P, Avvisati G, Papa G, Martino P: InvasiveFusarium solani infections in patients with acute leukemia. Review of Infectious Diseases 1988, 10: 653–660.

    Google Scholar 

  57. Young C, Meyers AM: Opportunistic fungal infection byFusarium oxysporum in a renal transplant patient. Sabouraudia 1979, 17: 219–223.

    PubMed  Google Scholar 

  58. Willemsen MJ, de Coninck AL, Coremans-Pelseneer JE, Marichal-Pipeleers MA, Roseeuw DI: Parasitic invasion ofFusarium oxysporum in an arterial ulcer in an otherwise healthy patient. Mykosen 1986, 29: 248–252.

    PubMed  Google Scholar 

  59. Attapattu MC, Ananda Krishnan C: Extensive subcutaneous hyphomycosis caused byFusarium oxysporum. Journal of Medical and Veterinary Mycology 1986, 24: 105–111.

    PubMed  Google Scholar 

  60. Perez Villarroya JC, Fernández Guerrero ML, Moran V, Ponte MC, Soriano F, Barat A, de Villalobos E:Fusarium oxysporum infection. Journal of Infection 1982, 5: 307–308.

    Google Scholar 

  61. Benjamin RP, Callaway JL, Conant NF: Facial granuloma associated withFusarium infection. Archives of Dermatology 1970, 101: 598–600.

    PubMed  Google Scholar 

  62. Datry A, Leblond V, Feger C, Gabarre J, Gueho E, Lecso G, Danis M, Binet JL, Gentilini M: A propos de trois cas de mycose àFusarium sp. Bulletin de la Société Française de Mycologie Médicale 1988, 17: 137–142.

    Google Scholar 

  63. Hiemenz JW, Kennedy B, Kwon-Chung KJ: Invasive fusariosis associated with an injury by a stingray barb. Journal of Medical and Veterinary Mycology 1990, 28: 209–213.

    PubMed  Google Scholar 

  64. Sayama K, Ohtsuka H, Shiraishi S, Miki Y, Tada M, Matsumoto T: Squamous cell carcinoma arising in long-standing granulomatous hyalohyphomycosis caused byFusarium solani. Archives of Dermatology 1991, 127: 1795–1837.

    Google Scholar 

  65. Thiamprasit M, Sivayathom A: Black dot mycetoma. Mykosen 1983, 27: 219–226.

    Google Scholar 

  66. Baudraz-Rosselet F, Monod M, Borradori L, Ginalsky JM, Vion B, Boccard C, Frenk E: Mycetoma of the foot due toFusarium sp. treated with oral ketoconazole. Dermatology 1992, 184: 303–305.

    PubMed  Google Scholar 

  67. Luque AG, Mugica MT, D'Anna ML, Alvárez DP: Micetoma podal porFusarium solani (Mart.). Appel & Wollenweber. Boletín Micológico 1991, 6: 55–57.

    Google Scholar 

  68. Hoog GS de, Buiting A, Tan CS, Stroebel AB, Ketterings C, Boer de EJ, Naafs B, Brimicombe R, Nohlmans-Paulsen MKE, Fabius GTJ, Klokke AH, Visser LG: Diagnostic problems with imported cases of mycetoma in the Netherlands. Mycoses 1993, 36: 81–87.

    PubMed  Google Scholar 

  69. Destombes P, Mariat F, Rosati L, Segretain C: Les mycetomas en Somalie — conclusions d'une enquette menée de 1959–1964. Acta Tropica 1977: 355–373.

  70. Hay RJ, Mackenzie DWR: Mycetoma (madura foot) in the United Kingdom — a survey of 44 cases. Clinical Experimental Dermatology 1983, 8: 553–562.

    Google Scholar 

  71. Anaissie E, Nelson P, Beremand M, Kontoyiannis D, Rinaldi M:Fusarium-caused hyalohyphomycosis — an overview. In: Borgers M, Hay R, Rinaldi MG (ed): Current topics in medical mycology. Springer-Verlag, New York, 1992, p. 231–249.

    Google Scholar 

  72. Page JC, Firedlander G, Dockery GL: PostoperativeFusarium osteomyelitis. Journal of Foot Surgery 1982, 21: 174–176.

    PubMed  Google Scholar 

  73. Nuovo MA, Simmonds JE, Chacho MS, Mckitrick JC:Fusarium solani osteomyelitis with probable nosocomial spread. American Journal of Clinical Pathology 1988, 90: 738–741.

    PubMed  Google Scholar 

  74. Bourguignon RL, Walsh AF, Flynn JC, Baro C, Spinos E:Fusarium species osteomyelitis. Case report. Journal of Bone and Joint Surgery 1976, 58: 722–723.

    PubMed  Google Scholar 

  75. Jackle C, Leek JC, Olson DA, Robbins DL: Septic arthritis due toFusarium solani. Journal of Rheumatology 1983, 10: 151–153.

    PubMed  Google Scholar 

  76. Gradon JD, Lerman A, Lutwick LI: Septic arthritis due toFusarium moniliforme. Reviews of Infectious Diseases 1992, 12: 716–717.

    Google Scholar 

  77. Kerr CM, Perfect JR, Craven PC, Jorgensen SH, Drutz D, Shelburne JD, Gallis HA, Gutman RA: Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Annals of Internal Medicine 1983, 99: 334–336.

    PubMed  Google Scholar 

  78. Roiz MP, Palacio A, Cuetara MS, Herrero JA, Sánchez R, Mazuecos A: Peritonitis en un paciente sometido a diálisis peritoneal continua ambulatoria. Enfermedades Infecciosas y Microbiologia Clínica 1993, 11: 221–222.

    Google Scholar 

  79. Chiaradia V, Schinella D, Pascoli L, Tesio F, Santini GF:Fusarium peritonitis in peritoneal dialysis: report of two cases. Microbiologica 1990, 13: 77–78.

    PubMed  Google Scholar 

  80. McNeely DJ, Vas SI, Dombros N, Oreopoulos DG:Fusarium peritonitis: an uncommon complication of continuous ambulatory peritoneal dialysis. Peritoneal Dialysis Bulletin 1981, 1: 94–96.

    Google Scholar 

  81. Young SB, Ahmed-Jushuf IH, Brownjhon AM, Parsons FM, Foulkes SJ, Evans EG: Opportunistic peritonitis in continuous ambulatory peritoneal dialysis. Clinical Nephrology 1984, 22: 268–269.

    Google Scholar 

  82. Rippon JW, Larson RA, Rosenthal DM, Clayman J: Disseminated cutaneous and peritoneal hyalohyphomycosis caused byFusarium species: three cases and review of the literature. Mycopathologia 1988, 101: 105–111.

    PubMed  Google Scholar 

  83. Placentini I, Biasioli S, Chiaramonte S, Fabris A, Feriani M, Bisani E, Romo C, Greca G:Fusarium verticillioides nuovo patogeno opportunista. Giornale di Malattie Infettive e Parassitarie 1984, 36: 64–67.

    Google Scholar 

  84. Valenstein P, Schell WA: Primary intranasalFusarium infection. Potential for confusion with rhinocerebral zygomycosis. Archives of Pathology and Laboratory Medicine 1986, 110: 751–754.

    PubMed  Google Scholar 

  85. Kurien M, Anandi V, Raman R, Brahmadathan KV: Maxillary sinus fusariosis in immunocompetent hosts. Journal of Laryngology and Otology 1992, 106: 733–736.

    PubMed  Google Scholar 

  86. Stammberger H: Endoscopic surgery for mycotic and chronic recurring sinusitis. Annals of Otology 1985, 94, Supplement 119: 1–11.

    Google Scholar 

  87. Laskownicka Z, Kurdzielewicz J, Macura A, Okrasinska-Cholewa B: Mycotic sinusitis in children. Mykosen 1978, 21: 407–411.

    PubMed  Google Scholar 

  88. Blazar BR, Hurd DD, Snover DG, Alexander JW, McGlave PB: InvasiveFusarium infections in bone marrow transplant recipients. American Journal of Medicine 1984, 77: 645–651.

    PubMed  Google Scholar 

  89. Anaissie E, Kantarajan H, Ro J, Hopfer R, Rolston K, Fainstein V, Bodey G: The emerging role ofFusarium infections in patients with cancer. Medicine 1989, 67: 77–83.

    Google Scholar 

  90. Steinberg GK, Britt RH, Enzmann DR, Finlay JL, Arvin AM:Fusarium brain abscess. Journal of Neurosurgery 1983, 58: 598–608.

    PubMed  Google Scholar 

  91. Abramowsky CR, Quinn D, Bradford WD, Conant NF: Systemic infection byFusarium in a burned child. The emergence of a saprophytic strain. Journal of Pediatrics 1974, 84: 561–564.

    PubMed  Google Scholar 

  92. Jorens PG, Van Den Heuvel PA, Cuykens JJ, Van Cauwelaert PA, Parizel GA, Mertens AN:Fusarium endocarditis involving aortic valve following coronary artery surgery. European Heart Journal 1990, 11: 476–478.

    PubMed  Google Scholar 

  93. Lozano M, Ribera JM, Puig J, Rives A, Sierra J, Grañena R, Rozman C: Broncoreumonía porFusarium solani en un paciente afectado de leucemia aguda mieloblástica. Enfermedades Infecciosas y Microbiología Clínica 1990, 8: 78–79.

    Google Scholar 

  94. Lupinetti FM, Giller RH, Trigg ME: Operative treatment ofFusarium fungal infections of the lung. Annals of Thoracic Surgery 1990, 49: 991–992.

    PubMed  Google Scholar 

  95. Lazarus JA, Scharwz LH: Infection of urinary bladder with an unusual fungus strain:Fusarium. Urologic and Cutaneous Review 1948, 52: 185–189.

    Google Scholar 

  96. Vartivarian SE, Anaissie EJ, Bodey GP: Emerging fungal pathogens in immunocompromised patients: classification, diagnosis, and management. Clinical Infectious Diseases 1993, 17, Supplement 2: 487–491.

    Google Scholar 

  97. Matsuda T, Matsumoto T: Disseminated hyalohyphomycosis in a leukemic patient. Archives of Dermatology 1986, 122: 1171–1175.

    PubMed  Google Scholar 

  98. Mowbray DN, Paller AS, Nelson PE, Kaplan RL: DisseminatedFusarium solani infection with cutaneous nodules in a bone marrow transplant patient. International Journal of Dermatology 1988, 27: 698–701.

    PubMed  Google Scholar 

  99. Merz WG, Karp JE, Hoagland M, Jett-Cohen M, Junkins JM, Hood AF: Diagnosis and successfull treatment of fusariosis in the compromised host. Journal of Infectious Diseases 1988, 158: 1046–1055.

    PubMed  Google Scholar 

  100. Legrand C, Anaissie E, Hashem R, Nelson P, Bodey GP, Ro J: Experimental fusarial hyalophyphomycosis in a murine model. Journal of Infectious Diseases 1991, 164: 944–948.

    PubMed  Google Scholar 

  101. Neumeister B, Bartmann P, Gaedicke G, Marre R: A fatal infection due toFusarium oxysporum in a child with Wilm's tumour. Case report and review of the literature. Mycoses 1992, 35: 115–119.

    PubMed  Google Scholar 

  102. Anaissie EJ, Rinaldi MG:Fusarium and the immunocompromised host: liaisons dangereuses. New York State Journal of Medicine 1990, 12: 586–587.

    Google Scholar 

  103. Richardson SE, Bannatyne RM, Summerbell RC, Milliken J, Gold R, Weitzman SS: Disseminated fusarial infection in the immunocompromised host. Reviews of Infectious Diseases 1988, 10: 1171–1181.

    PubMed  Google Scholar 

  104. Girmenia C, Arcese W, Micozzi A, Martino P, Bianco P, Morace G: Onychomycosis as a possible origin of disseminatedFusarium solani infection in a patient with severe aplastic anemia. Clinical Infectious Diseases 1992, 14: 1167.

    PubMed  Google Scholar 

  105. Gamis AS, Gunadson T, Giebink GS, Ramsay NKC: Disseminated infection withFusarium in recipients of bone marrow transplants. Reviews of Infectious Diseases 1991, 13: 1077–1088.

    PubMed  Google Scholar 

  106. Caux F, Aractingi S, Baurmann H, Reygagne P, Dombret H, Romand S, Dubertret L:Fusarium solani cutaneous infection in a neutropenic patient. Dermatology 1993, 186: 232–235.

    PubMed  Google Scholar 

  107. Frankland AW: Clinical cross-reactions between various moulds with special reference toFusarium. Experientia Supplementum 1987, 51: 147–151.

    PubMed  Google Scholar 

  108. Okuda C, Ito M, Sato Y, Oka K, Hotchi M: Disseminated cutaneousFusarium infection with vascular invasion in a leukemic patient. Journal of Medical and Veterinary Mycology 1987, 25: 177–186.

    PubMed  Google Scholar 

  109. Kaufman L: Laboratory methods for the diagnosis and confirmation of systemic mycoses. Clinical Infectious Diseases 1992, 14, Supplement 1: 523–529.

    Google Scholar 

  110. Arrese-Estrada JA, Stynen D, Goris A, Pierard GE: Identification immunohistochimique desAspergillus par l'anticorp monoclonal EB-AI. Annals of Pathology 1990, 10: 198–200.

    Google Scholar 

  111. Chaulk CP, Smith PW, Feagler JR, Verdirame J, Commers JR: Fungemia due toFusarium solani in an immunocompromised child. Pediatric Infectious Disease Journal 1986, 5: 363–366.

    Google Scholar 

  112. Viviani MA, Cofrancesco F, Boschetti C, Tortorano AM, Cortellaro M: Eradication ofFusarium infection in a leukopenic patient treated with liposomal amphotericin B. Mycoses 1991, 34: 255–256.

    PubMed  Google Scholar 

  113. Engelhard D, Eldor A, Polacheck I, Hardan I, Ben-Yehuda D, Anselem S, Salkin IF, López-Berestein G, Sacks T, Rachmilewitz EA, Barenholz Y: Disseminated visceral fusariosis treated with amphotericin Bphospolipid complex. Leukemia and Lymphoma 1993, 9: 385–392.

    PubMed  Google Scholar 

  114. Cofrancesco E, Boschetti C, Viviani MA, Bargiggia C, Tortorano AM, Cortellaro M, Zanussi C: Efficacy of liposomal amphotericin B (AmBisome) in the eradication ofFusarium infection in a leukaemic patient. Haematologica 1992, 77: 280–283.

    PubMed  Google Scholar 

  115. Christensen RD: Hemotherapy in the treatment of sepsis neonatorum. In: Karprisin DO, Luban NL (ed): Pediatric transfusion medicine. CRC Press, Boca Ratón, 1987, p. 79–89.

    Google Scholar 

  116. Barrios NK, Kirkpatrick DV, Murciano A, Stine K, Van Dyke RB, Humbert JR: Successful treatment of disseminatedFusarium infection in an immunocompromised child. American Journal of Pediatric Hematology/Oncology 1990, 12: 319–324.

    PubMed  Google Scholar 

  117. Helm TN, Longworth DL, Hall GS, Bolwell BJ, Fernandez B, Tomecki KJ: Case report and review of resolved fusariosis. Journal of the American Academy of Dermatology 1990, 23: 393–398.

    PubMed  Google Scholar 

  118. Minor RL, Pfaller MA, Gingrich RD, Burns LJ: DisseminatedFusarium infections in patients following bone marrow transplantation. Bone Marrow Transplantation 1989, 4: 653–658.

    PubMed  Google Scholar 

  119. Spielberger RT, Fallcroni MJ, Coene AJ, Larson RJ: Concomitant amphotericin B therapy, granulocyte transfusion, and GM-CSF administration for disseminated infection withFusarium in a granulocytopenic patient. Clinical Infectious Diseases 1993, 16: 528–530.

    PubMed  Google Scholar 

  120. Melcher GP, McGouth DA, Fothergill AW, Norris C, Rinaldi MG: Disseminated hialohyphomycosis caused by a novel human pathogen,Fusarium napiforme. Journal of Clinical Microbiology 1993, 31: 1461–1467.

    PubMed  Google Scholar 

  121. Rabodonirina M, Piers MA, Monier MF, Guého E, Fiére D, Mojon M:Fusarium infections in immunocompromised patients: case reports and literature review. European Journal of Clinical Microbiology & Infectious Diseases 1994, 13: 152–161.

    Google Scholar 

  122. Hennequin C, Benkerrou M, Gaillard JL, Blanche S, Fraitag S: Role of granulocyte colony-stimulating factor in the management of infection withFusarium oxysporum in a neutropenic child. Clinical Infectious Diseases 1994, 18: 490–491.

    PubMed  Google Scholar 

  123. Castagnola E, Garaventa A, Conte M, Barretta A, Faggi E, Viscoli C: Survival after fungemia due toFusarium moniliforme in a child with neuroblastoma. European Journal of Clinical Microbiology & Infectious Diseases 1993, 12: 308–309.

    Google Scholar 

  124. Kiehn TE, Nelson PE, Bernard EM, Edwards FF, Koziner B, Amstrong D: Catheter associated fungemia caused byFusarium chlamydosporum in a patient with lymphocytic lymphoma. Journal of Clinical Microbiology 1985, 21: 501–504.

    PubMed  Google Scholar 

  125. Cuétara MS, Sanz F, Palacio A, Campbell CK, Aguado JM, Lizasoain M, Gómez-Sánchez MA, Castejón AM: Hallazgo de hongo micelial en hemocultivo (Bactec NR860) en una paciente con fiebre portadora de reservorio. Enfermedades Infecciosas y Microbiología Clínica 1993, 11: 567–568.

    Google Scholar 

  126. Sanz F, Cuétara MS, Palacio A, Campbell CK, Johnson L, Urruzura P, Roiz MP: Problemas que plantea el aislamiento en hemocultivo (Bactec NR-860) de hongos miceliales (Fusarium solani). Enfermedades Infecciosas y Microbiología Clínica 1993, 11: 490–494.

    Google Scholar 

  127. Nati R, Dreyfus F, Lanose JJ, Brunet F, Robin P, Bordier C, Dupouy-Camet J: Localisations cutanées d'une septicémie àFusarium oxysporum survenant chez un patient en aplaisie médullaire. Annales de Dermatologie et de Venéreologie 1988, 115: 337–338.

    Google Scholar 

  128. Reuben A, Anaissie E, Nelson PE, Hashem R, Legrand C, Ho DH, Bodey GP: Antifungal susceptibility of 44 clinical isolates ofFusarium species determined by using a broth microdilution method. Antimicrobial Agents and Chemotherapy 1989, 33: 1647–1649.

    PubMed  Google Scholar 

  129. Rotowa NA, Shadomy HJ, Shadomy S: In vitro activities of polyene and imidazole antifungal agents against unusual opportunistic fungal pathogens. Mycoses 1990, 33: 203–211.

    PubMed  Google Scholar 

  130. Sekhon AS, Padhye AA, Garg AK, Ahmad H, Moledina N: In vitro sensitivity of medically significantFusarium species to various antimycotics. Chemotherapy 1994, 40: 239–244.

    PubMed  Google Scholar 

  131. Stern GA: In vitro antibiotic synergism against ocular fungal isolates. American Journal of Ophthalmology 1978, 86: 359–367.

    PubMed  Google Scholar 

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  1. Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, 43201, Reus, Spain

    J. Guarro & J. Gené

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  1. J. Guarro
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Guarro, J., Gené, J. Opportunistic fusarial infections in humans. Eur. J. Clin. Microbiol. Infect. Dis. 14, 741–754 (1995). https://doi.org/10.1007/BF01690988

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  • DOI: https://doi.org/10.1007/BF01690988

Keywords

  • Neutropenia
  • Fungal Infection
  • Antifungal Agent
  • Invasive Fungal Infection
  • Fusarium Species