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In vitro study of the potential role of quinupristin/ dalfopristin in the treatment of catheter-related staphylococcal infections

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Abstract

The susceptibility of clinical isolates of methicillinsusceptible and -resistant staphylococci from cancer patients with central venous catheter bacteremia to quinupristin/dalfopristin, a semisynthetic streptogramin, was determined in vitro. Susceptibility of these isolates to nine other antistaphylococcal antibiotics was also determined for comparison. A total of 197 staphylococcal strains were tested from 1983 to 1992. Quinupristin/dalfopristin was bactericidal against all isolates, independent of their resistance to methicillin. Its activity was similar to that of vancomycin but superior to that of teicoplanin. Quinupristin/dalfopristin may prove to be an important addition to our armamentarium against catheter-related Staphylococcal infections.

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Authors and Affiliations

  1. Department of Medical Specialties, Section of Infectious Diseases, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 47, 77030, Houston, Texas, USA

    R. Garcia & I. Raad

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  1. R. Garcia
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  2. I. Raad
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Garcia, R., Raad, I. In vitro study of the potential role of quinupristin/ dalfopristin in the treatment of catheter-related staphylococcal infections. Eur. J. Clin. Microbiol. Infect. Dis. 15, 933–936 (1996). https://doi.org/10.1007/BF01690511

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