Skip to main content

Evaluation of mutagenic activity of turmeric extract containing curcumin, before and after activation with mammalian cecal microbial extract of liver microsomal fraction, in the amesSalmonella test

This is a preview of subscription content, access via your institution.

References

  1. Abraham S, Abraham SK, Radhamony G (1976) Mutagenic potentials of the condiments, ginger and turmeric, Cytologia 41:591–595

    PubMed  Google Scholar 

  2. Abraham SK, Kesavan PC (1984) Genotoxicity of garlic, turmeric and asafoetida in mice. Mutation Res 136: 85–88

    PubMed  Google Scholar 

  3. Ames BM, McCann J, Yamasaki E (1975) Methods for determining carcinogens and mutagens with theSalmonella/mammalian microsame mutagenicity test. Mutation Res 31:347–364

    PubMed  Google Scholar 

  4. Anon (1971) Specifications for the identity and purity of some extraction solvents and certain other substances, FAO Nutrition Meetings, Report Series No. 488, WHO/Food Add/70.40

  5. Anon (1982) Evaluation of certain food additives and contaminants, Twentysixth report of the Joint FAO/WHO Expert Committee on Food Additives, Technical report series 683, WHO, Geneva, pp 22

  6. Bonin AM, Baker RSU (1980) Mutagenicity testing of some approved food additives withSalmonella/microsome assay. Food Technology (Australia) 32:608–611

    Google Scholar 

  7. Brown JP, Dietrich PS (1979) Mutagenicity of plant flavonols in theSalmonella/mammalian microsome test, Activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources. Mutation Res 66:223–240

    PubMed  Google Scholar 

  8. Goodpasture CE, Rrrighi FE (1976) Effects of food seasoning on the cell cycle and chromosome morphology of mammalian cellsin uitro with special reference to turmeric. Food Cosmet Toxicol 14:9–14

    PubMed  Google Scholar 

  9. Hoensch HP, Schwenk M (1984) Intestinal absorption and metabolism of xenobiotics in humans. In: Schiller CM (Ed) Intestinal toxicology, Raven Press, New York, pp 169–192

    Google Scholar 

  10. Holder GM, Plummer J, Ryan AJ (1978) The metabolism and excretion of curcumin [1,7-bis(4 hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] in the rat. Xenobiotica 8:761–768

    PubMed  Google Scholar 

  11. Jensen NJ (1982) Lack of mutagenic effect of turmeric oleoresin and curcumin in theSalmonella/mammalian microsome test, Mutation Res 105:393–396

    PubMed  Google Scholar 

  12. Levin DE, Yamasaki E, Ames BN (1982) The newSalmonella tester strain TA 97a for the detection of frame shift mutagens, Mutation Res 94:315–330

    PubMed  Google Scholar 

  13. Lu AYH, Kuntzman R, West S, Jacobson M, Conney AH (1972) Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. J Biol Chem 247:1727–1734

    PubMed  Google Scholar 

  14. Maron DM, Ames BN (1983) Revised methods for theSalmonella mutagenicity test. Mutation Res 113: 173–215

    PubMed  Google Scholar 

  15. Pamukcu AM, Yalciner S, Hatcher JF, Bryan GT (1980) Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res 40, 3468–3472

    PubMed  Google Scholar 

  16. Prins RA (1978) Nutritional impact of intestinal drug-microbe interactions. In: Hathcock JN, Coon J (Eds), Nutrition and drug interrelations. Academic Press, New York, pp 189–203

    Google Scholar 

  17. Ravindranath V, Chandrasekhara N (1980) Absorption and tissue distribution of curcumin in rats. Toxicology 16:259–265

    PubMed  Google Scholar 

  18. Ravindranath V, Chandrasekhara N (1981)In vitro studies on the intestinal absorption of curcumin in rats. Toxicology 22:251–257

    Google Scholar 

  19. Ravindranath V, Chandrasekhara N (1982) Metabolism of curcumin — Studies with (3H)curcumin. Toxicology 22: 337–344

    Google Scholar 

  20. Tamura GC, Gold A Ferro-Luzzi, Ames BN (1980) Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. Proc Natl Acad Sci (USA) 77:4961–4965

    Google Scholar 

  21. Timberlake CF, Henry BS (1986) Plant pigment as natural food colours. Endeavour 10:31–36

    PubMed  Google Scholar 

  22. Vijayalaxmi (1980) Genetic effects of turmeric and curcumin in mice and rats. Mutation Res 79:125–132

    PubMed  Google Scholar 

  23. Wahlstorm BO, Blennow G (1978) A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol 43: 86–92

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Manohar S. Netrawali.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shah, R.G., Netrawali, M.S. Evaluation of mutagenic activity of turmeric extract containing curcumin, before and after activation with mammalian cecal microbial extract of liver microsomal fraction, in the amesSalmonella test. Bull. Environ. Contam. Toxicol. 40, 350–357 (1988). https://doi.org/10.1007/BF01689091

Download citation

Keywords

  • Waste Water
  • Water Management
  • Water Pollution
  • Curcumin
  • Mutagenic Activity