Skip to main content
Log in

Influence of Pb, Cd, Zn, Mn, Cu, Hg, or Be salts on the glutathione S-transferases of the rat liver

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Asaoka K, Takahashi K (1977) Monkey glutathione S-aryltransferases. J Biochem 82:1313–1323

    PubMed  Google Scholar 

  • Baars AJ, Jansen M, Breimer DD (1978) The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. Biochem Pharmacol 27:2487–2494

    PubMed  Google Scholar 

  • Chand P, Clausen J (1982) Triethyl lead toxicity in relation to brain glutathione and glutathione S-transferase. Tox Lett 12:181–184

    Google Scholar 

  • Chasseaud LF (1979) The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv Cancer Res 29:175–274

    PubMed  Google Scholar 

  • Dierickx PJ (1982) In vitro inhibition of the soluble glutathione S-trans-ferases from rat liver by heavy metals. Enzyme 27:25–32

    PubMed  Google Scholar 

  • Dierickx PJ (1985) In vitro interaction of organic mercury compounds with soluble glutathione S-transferases from rat liver. Pharmac Res Commun 17:489–500

    Google Scholar 

  • Douch PG, Buchanan LL (1978) Glutathione conjugation of some xeno-biotics by Ascaris suum and Moniezia expansa. Xenobiotica 8:171–176

    PubMed  Google Scholar 

  • Dunnett CW (1955) A multiple comparison procedure for comparing several treatments with a control. Am Statist Ass J 50:1096–1121

    Google Scholar 

  • Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77

    PubMed  Google Scholar 

  • Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases — The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130–7139

    PubMed  Google Scholar 

  • Henry RA, Byington KH (1976) Inhibition of glutathione S-aryltransferase from rat liver by organogermanium, lead and tin compounds. Biochem Pharmac 25:2291–2295

    Google Scholar 

  • Kobayashi S, Kimura M (1985) Effects of orally administered cadmium on alkaline phosphatase isoenzymes in rat tissues. J Pharmacobio-Dyn 8:853–863

    PubMed  Google Scholar 

  • Lowry OH, Rosebrough NJ, Fair AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275

    PubMed  Google Scholar 

  • Mannervik B, Guthenberg C, Jensson H, Warholm M, Alin P (1983) Isoenzymes of glutathione S-transferases in rat and human tissues. In: Larsson A et al. (eds) Functions of glutathione: biochemical, physiological, toxicological, and clinical aspects. Raven Press, New York, pp 75–88

    Google Scholar 

  • Parkki MG, Ahotupa M, Aitio M (1978) Inhibition of epoxide hydrase and glutathione S-transferase by heavy metals in vitro. In: Aitio M (ed) Conjugation reactions in drug biotransformation. Elsevier North-Holland, Amsterdam, p 516

    Google Scholar 

  • Reddy CC, Scholz RW, Massaro EJ (1981) Cadmium, methylmercury, mercury, and lead inhibition of calf liver glutathione S-transferase exhibiting selenium-independent glutathione peroxidase activity. Tox Appl Pharmac 61:460–468

    Google Scholar 

  • Siegers C-P, Schenke M, Younes M (1987) Influence of cadmium chloride, mercuric chloride, and sodium vanadate on the glutathione-conjugating enzyme system in liver, kidney, and brain of mice. J Toxicol Environ Hlth 22:141–148

    Google Scholar 

  • Schreiner E, Freundt KJ (1985) Activities of hepatic epoxide hydrolase and glutathione S-transferase in rats under the influence of tetramethyl thiuramdisulfide, tetramethyl thiurarnmonosulfide or dimethyl dithiocarbamate. Tox Lett 25:147–152

    Google Scholar 

  • Schreiner E, Freundt KJ (1986) Inhibition of hepatic epoxide hydrolase and glutathione S-transferase in rats by bis(dimethyldithiocarbamato) zinc (ziram). Bull Environ Contam Toxicol 37:53–54

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freundt, K.J., Ibrahim, H.A. Influence of Pb, Cd, Zn, Mn, Cu, Hg, or Be salts on the glutathione S-transferases of the rat liver. Bull. Environ. Contam. Toxicol. 46, 618–624 (1991). https://doi.org/10.1007/BF01688208

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01688208

Keywords

Navigation