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Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds

Summary

In course of prolonged exposure /14 weeks/ to various mercury compounds /MetHg — a fluid seed-dressing preparation 0,8, Phenyl and Ethyl chlorides and.HgCl2 in doses corresponding to 5% of DL50/3 times weekly/, enhanced levels of activity of malate dehydrogenase /MDH/ and glucosephosphate isomerase /PHI/ in blood serum were observed. After 7 weeks of exposure about fourfold increase of MDH and 2-3-fold enhancement of PHI activities were found relative to controls. After 14 weeks of exposure in livers of rats, given MetHg and EtHg, organic mercury was found at concentrations of 28,8 and 4 μg/g tissue, respectively. Inorganic mercury in liver was found in animals given all compounds and concentrations were in the range of 1,2 – 4,7 μg/g tissue.

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The study was partly subsidised by the Polish-American agreement 05-009-2 with the National Institute of Occupational Safety and Health, PHS, USA. Chief investigator — doc. dr hab. O.K. Piotrowski.

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Chmielnicka, J., Balcerska, I., Pietruszczak, A. et al. Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds. Bull. Environ. Contam. Toxicol. 17, 447–455 (1977). https://doi.org/10.1007/BF01685937

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Keywords

  • Malate Dehydrogenase
  • Inorganic Mercury
  • Mercury Compound
  • Glucosephosphate Isomerase
  • Mercury Vapour Concentration