Summary
Varying doses of TCDD ranging from 25 to 1000 μg/kg were administered to the larval and adult forms of the American bullfrog,Rana catesbeiana. Doses of TCDD as high as 1 mg/kg failed to have any significant effect upon survival or completion of metamorphosis in tadpole and doses of up to 500 μg/kg had no effect on survival of adult frogs. Histopathological examination of various tissues from the metamorphosed tadpoles and adult frogs failed to show any abnormalities.
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This work was supported by USPHS Grant ES00267. The Training support of ES 07028 is also gratefully acknowledged.
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Beatty, P.W., Holscher, M.A. & Neal, R.A. Toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in larval and adult forms ofRana catesbeiana . Bull. Environ. Contam. Toxicol. 16, 578–581 (1976). https://doi.org/10.1007/BF01685367
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DOI: https://doi.org/10.1007/BF01685367