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Methoxychlor effects on hepatic storage of vitamin A in rats

Summary

Sixty Sprague-Dawley rats were fed diets containing 0, 10, 100, 1,000, and 10,000 ppm of methoxychlor for 16 weeks underad libitum- and restricted-feeding regimens. Methoxychlor at 10,000 ppm was lethal to some rats, reduced food consumption and growth, and increased liver weight relative to body weight. Methoxychlor at 1,000 ppm reduced food consumption and growth of rats fedad libitum but did not reduce growth of restricted-fed rats. Reduced hepatic storage of vitamin A was detectable when methoxychlor was fed at levels of 100 ppm or higher.

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Davison, K.L., Cox, J.H. Methoxychlor effects on hepatic storage of vitamin A in rats. Bull. Environ. Contam. Toxicol. 16, 145–148 (1976). https://doi.org/10.1007/BF01685220

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Keywords

  • Liver Weight
  • Methoxychlor
  • Liver Enlargement
  • Average Daily Consumption
  • Body Weight Liver