Skip to main content

Effect of organochlorine compounds on serum proteins


Many OCC are at present current constituents of the global ecosystem. Their biological effects are of great interest to ecologists and environmental toxicologists.

This paper deals with the interrelationship between OCC (p,p′-DDT, Dieldrin and Arochlor 1221) and the serum level of protein fractions in rabbits receiving the above-mentioned compounds.

Sixty rabbits were divided into 6 groups given respectively no OCC, 200 ppm p,p′-DDT, 50 ppm Dieldrin, 200 ppm Arochlor-1221, 100 ppm p,p′-DDT and 100 ppm Arochlor-1221, 25 ppm Dieldrin and 100 ppm Arochlor in their drinking water which contained 6‰ ethyl alcohol in all groups.

After p,p′-DDT administration the increased plasma levels of DDT were accompanied by increased levels of Dieldrin,γ-BHC and PCBs, although the animals did not receive extra dosage of these OCC, except the amounts currently present in food and water. Dieldrin administration led to a concomitant increase in total DDT plasma level. A moderate increase in total DDT plasma level occurred also after the administration of PCBs. When administered concomitantly, in half doses, the same results were obtained at a lower level.

Variations in plasma level of different OCC as a result of feeding a given compound may explain differences in the degree of toxicity based on the resultant of metabolic interrelationships of OCC in the animal body.

The serum level of gamma globulin fractions (IgG and IgM) shows a tendency to decrease in rabbits given OCC. The serum albumin level rose in rabbits receiving OCI and fell in those receiving PCBs. In regard to the biological effects of OCC these facts point to a moderation of the activity of the immunological system.

This is a preview of subscription content, access via your institution.


  1. 1.

    ANDERSON, D.W., J.J. HICKEY, R.W. RISEBROUGH, D.F. HUGHES and R.E. CHRISTENSEN: Canadian Field-Naturalist83, 91 (1969).

    Google Scholar 

  2. 2.

    ARMOUR, A. JUDITH and J.A. BRUKE: J. of the AOAC53, 761 (1970).

    Google Scholar 

  3. 3.

    BAGLEY, G.E., W.L. REICHEL and E. CROMARTIE: J. of Ass. of Official Analytical Chemists53, 251 (1970).

    Google Scholar 

  4. 4.

    BIROS, FRANCIS J., AMITA C. WALKER and ANGELA MEDBERY: Bull. Env. Cont. and Toxic.5, 317 (1970).

    Google Scholar 

  5. 5.

    DRINKER, C.K., W.F. WARREN and G.A. BENNELL: J. Ind. Hyg. Toxicol.19, 283 (1937).

    Google Scholar 

  6. 6.

    Dustman, E.M., L.F. Stickel, L.J. Blus, W.L. Reichel and S.N. Wiemeyer: Transactions of the Thirty-Sixth North American Wildlife and Natural Resources Conference, March 17–20, 1971.

  7. 7.

    FAHEY, Y.L. and E.M. McKELVEY: J. Immun.94, 98 (1965).

    Google Scholar 

  8. 8.

    HOLMES, D.C., J.H. SIMMONS and J.O.G. TATLON: Nature216, 227 (1967).

    PubMed  Google Scholar 

  9. 9.

    HOWELL, D.E.: Proc. Oklahoma Acad. Sci.29, 31 (1948).

    Google Scholar 

  10. 10.

    IRISH, O.D.: Industrial Hygiene and Toxicology. Vol. 2. New York: F.A. Patty Ed. 1963.

    Google Scholar 

  11. 11.

    JENSEN, S.: New Sci.32, 612 (1966).

    Google Scholar 

  12. 12.

    Jensen, S.: PCB Conference, Uppsala, September 29,1970.

  13. 13.

    KOEMAN, J.H., TEN NOEVER, M.D. DE BRAUW and R.H. DE VOS: Nature221, 1126 (1969).

    PubMed  Google Scholar 

  14. 14.

    Lichtenstein, E.P., K.R. Schultz, T.W. Fuhremann and T.T. Liang: J. of Econ. Entomol. p. 761 (1969).

  15. 15.

    MILLER, J.W.: U.S. Public Health Rec.59, 1085 (1944).

    Google Scholar 

  16. 16.

    MULHERN, B.M., W.L. REICHEL, L.N. LOCKE, T.G. LAMONT, A. DELISLE, E. CROMARTIE, G.E. BAGLEY and R.M. PROUTY: Pesticides Monitoring J.4, 141 (1970).

    Google Scholar 

  17. 17.

    PEAKAL, D.B. and J.L. LINCER: BioScience20, 958 (1970).

    Google Scholar 

  18. 18.

    PREOTT, JAN, D.Y. JEFFERES and N.W. MOORE: Environmental Pollution1, 3 (1970).

    Google Scholar 

  19. 19.

    REICHEL, W.L., E. CROMARTIE, THAIR G. LAMONT, BERNARD M. MULHERN and R.M. PROUTY: Pesticides Monitoring J.3, 142 (1969).

    Google Scholar 

  20. 20.

    RISEBROUGH, R.W., P. REICHE, D.B. PEAKALL, S.G. HEIMAN and M.N. KINVEN: Nature220, 1098 (1968).

    PubMed  Google Scholar 

  21. 21.

    VOS, J.G. and R.B. BEEMS: Toxic. Appl. Pharmacol.19, 617 (1971).

    PubMed  Google Scholar 

  22. 22.


    PubMed  Google Scholar 

  23. 23.

    VOS, J.G. and TH. DE ROIJ: Toxic. Appl. Pharmacol.21, 549 (1972)

    PubMed  Google Scholar 

  24. 24.

    WASSERMANN, M., DORA WASSERMANN, E. KEDAR and M. DJAVAHERIAN: Bull. Env. Cont. and Toxicol.6, 426 (1971).

    Google Scholar 

  25. 25.

    WASSERMANN, M., DORA WASSERMANN, E. KEDAR, M. DJAVAHERIAN and SIMI CUCOS: Bull. Environ, Cont. and Toxicol. 8, 177 (1972).

    Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wassermann, M., Wassermann, D., Kedar, E. et al. Effect of organochlorine compounds on serum proteins. Bull. Environ. Contam. Toxicol. 10, 42–50 (1973).

Download citation


  • PCBs
  • Ethyl Alcohol
  • Serum Albumin Level
  • Dieldrin
  • Animal Body