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Documentation of vasomotor dysfunction by indicator dilution curve analysis

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Abstract

Indocyanine green dye dilution curves with abnormal contours have been recorded in four patients with acute and critical illnesses using standardized recording methods. The abnormal curves are characterized by a high and prolonged concentration of dye occurring after the peak concentration. This altered contour can be detected by use of routine mathematical processing since the derived hemodynamic parameters are affected by the altered contour. A physiologic basis for the altered curve contour is proposed.

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References

  1. Cohn, J.D., Del Guercio, L.R.M.: Clinical applications of indicator dilution curves as gamma functions. J. Lab. clin. Med.69, 675 (1967)

    PubMed  Google Scholar 

  2. Cohn, J.D., Engler, P.E., Del Guercio, L.R.M.: The automated physiologic profile. Crit. Care Med.3, 51 (1975)

    PubMed  Google Scholar 

  3. Coulam, C.M., Warner, H.R., Wood, E.H., Bassingthwaighte, J.B.: A transfer function analysis of coronary and renal circulation calculated from upstream and downstream indicator dilution curves. Circulat. Res.19, 879 (1966)

    PubMed  Google Scholar 

  4. Gudwin, A.L., Goldstein, C.R., Cohn, J.D., Del Guercio, L.R.M.: Estimation of ventricular mixing volume for prediction of operative mortality in the elderly. Ann. Surg.168, 183 (1968)

    PubMed  Google Scholar 

  5. Harris, T.R.: The identification of recirculatory systems in the frequency domain. Bull. Math. Phys.30, 87 (1968)

    Google Scholar 

  6. Kelman, G.R.: Errors in the processing of dye dilution curves. Circulat. Res.28, 543 (1966)

    Google Scholar 

  7. Kinsman, J.M., Moore, J.W., Hamilton, W.F.: Studies on the circulation. I. Injection method: Physical and mathematical consideration. Amer. J. Physiol.89, 322 (1929)

    Google Scholar 

  8. McIntosh, H.D., Gleason, W.L., Miller, D.E., Bacos, J.M.: A major pitfall in the interpretation of “central blood volume”. Circulat. Res.9, 1223 (1961)

    Google Scholar 

  9. Nicholes, K.K., Warner, H.R.: A study of dispersion of an indicator in the circulation. Ann. N. Y. Acad. Sci.115, 721 (1964)

    PubMed  Google Scholar 

  10. Shah, D.M., Dutton, R.E., Newell, J.C., Powers, S.R.: Vascular autoregulatory failure following trauma and shock. Surg. Forum28, 11 (1977)

    PubMed  Google Scholar 

  11. Starmer, C.R., Clark, D.O.: Computer computations of cardiac output using the gamma function. J. appl. Physiol.28, 219 (1970)

    PubMed  Google Scholar 

  12. Stewart, G.N.: A new method for measuring the velocity of the blood. Proc. physiol. Soc.5, XV (1890)

    Google Scholar 

  13. Thompson, H.J., Starmer, C.F., Whalen, R.E., McIntosh, H.d.: Indicator transit time considered as a gamma variate. Circulat. Res.14, 502 (1964)

    PubMed  Google Scholar 

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Skiles, M., Cohn, J.D., Engler, P.E. et al. Documentation of vasomotor dysfunction by indicator dilution curve analysis. Intensive Care Med 4, 93–97 (1978). https://doi.org/10.1007/BF01684392

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