Abstract
Indocyanine green dye dilution curves with abnormal contours have been recorded in four patients with acute and critical illnesses using standardized recording methods. The abnormal curves are characterized by a high and prolonged concentration of dye occurring after the peak concentration. This altered contour can be detected by use of routine mathematical processing since the derived hemodynamic parameters are affected by the altered contour. A physiologic basis for the altered curve contour is proposed.
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Cohn, J.D., Del Guercio, L.R.M.: Clinical applications of indicator dilution curves as gamma functions. J. Lab. clin. Med.69, 675 (1967)
Cohn, J.D., Engler, P.E., Del Guercio, L.R.M.: The automated physiologic profile. Crit. Care Med.3, 51 (1975)
Coulam, C.M., Warner, H.R., Wood, E.H., Bassingthwaighte, J.B.: A transfer function analysis of coronary and renal circulation calculated from upstream and downstream indicator dilution curves. Circulat. Res.19, 879 (1966)
Gudwin, A.L., Goldstein, C.R., Cohn, J.D., Del Guercio, L.R.M.: Estimation of ventricular mixing volume for prediction of operative mortality in the elderly. Ann. Surg.168, 183 (1968)
Harris, T.R.: The identification of recirculatory systems in the frequency domain. Bull. Math. Phys.30, 87 (1968)
Kelman, G.R.: Errors in the processing of dye dilution curves. Circulat. Res.28, 543 (1966)
Kinsman, J.M., Moore, J.W., Hamilton, W.F.: Studies on the circulation. I. Injection method: Physical and mathematical consideration. Amer. J. Physiol.89, 322 (1929)
McIntosh, H.D., Gleason, W.L., Miller, D.E., Bacos, J.M.: A major pitfall in the interpretation of “central blood volume”. Circulat. Res.9, 1223 (1961)
Nicholes, K.K., Warner, H.R.: A study of dispersion of an indicator in the circulation. Ann. N. Y. Acad. Sci.115, 721 (1964)
Shah, D.M., Dutton, R.E., Newell, J.C., Powers, S.R.: Vascular autoregulatory failure following trauma and shock. Surg. Forum28, 11 (1977)
Starmer, C.R., Clark, D.O.: Computer computations of cardiac output using the gamma function. J. appl. Physiol.28, 219 (1970)
Stewart, G.N.: A new method for measuring the velocity of the blood. Proc. physiol. Soc.5, XV (1890)
Thompson, H.J., Starmer, C.F., Whalen, R.E., McIntosh, H.d.: Indicator transit time considered as a gamma variate. Circulat. Res.14, 502 (1964)
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Skiles, M., Cohn, J.D., Engler, P.E. et al. Documentation of vasomotor dysfunction by indicator dilution curve analysis. Intensive Care Med 4, 93–97 (1978). https://doi.org/10.1007/BF01684392
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DOI: https://doi.org/10.1007/BF01684392