Skip to main content
SpringerLink
Log in

Drug effects on dieldrin storage in rat tissue

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Summary

Selected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after 10 days of treatment and abdominal adipose tissue was analyzed for dieldrin using electron capture gas chromatography.

Heptabarbital (40 and 225 mg/kg rat/day), aminopyrine (75 and 350 mg/kg rat/day), tolbutamide (60 and 290 mg/kg rat/day), and phenylbutazone (90 mg/kg rat/day) were effective as feed additives in reducing tissue dieldrin. Heptabarbital was the most effective and reduced the concentration of tissue dieldrin by 80 per cent at the higher dose level. In comparison, DDT (4 mg/kg rat/day) effected a 72 per cent reduction. A contrast with DDT was also observed in trials with i.p. administration of drugs and DDT. In those trials, the duration of the DDT action was apparently greater than that of the drugs.

We suggest that suitable drugs might be used to reduce insecticide accumulation in the tissues of animals and man, and for treatment of individuals after over exposure to insecticides.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. CLABORN, H. V., R. D. RADELEFF, and R. C. BUSHLAND, U.S.D.A. Bulletin, ARS-33-63, (1960)

  2. STREET, J. C., Science140, 1580 (1964)

    Article  Google Scholar 

  3. HART, L. G. and J. R. FOUTS, Proc. Soc. Exp. Biol. Med.114, 388 (1963)

    CAS  Google Scholar 

  4. REMMER, H., Proc. First International Pharmacological Meeting, Vol 6, p 235, (1962), Pergamon Press, Oxford.

    Google Scholar 

  5. CONNEY, A. H., C. DAVISON, R. GASTEL and J. J. BURNS, J. Pharmacol. Exp. Therap.130, 1 (1960)

    CAS  Google Scholar 

  6. DAYTON, P. G., Y. TARCAN, T. CHENKIN, and M. WEINER, J. Clin. Invest.,40., 1797 (1961)

    CAS  Google Scholar 

  7. CUETO, C., JR., and W. J. HAYES, JR., Toxicol. and Appl. Pharmacol.,7, 481 (1965)

    Google Scholar 

  8. KORANSKY, W., J. PORTIG, H. W. VOILAND and I. KLEMPAU, Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak.,247, 49 (1964)

    Article  CAS  Google Scholar 

  9. BRODIE, B. B. and R. P. MAICKEL, Proc. First International Pharmacological Meeting, Vol. 6, p 299, (1962), Pergamon Press, Oxford.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Animal Science Department, Utah State University, USA

    J. C. Street, M. Wang & A. D. Blau

Authors
  1. J. C. Street
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. D. Blau
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Street, J.C., Wang, M. & Blau, A.D. Drug effects on dieldrin storage in rat tissue. Bull Environ Contam Toxicol 1, 6–15 (1966). https://doi.org/10.1007/BF01684070

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01684070

Keywords

Search

Navigation