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Effect of dieldrin on the stability of lysosomes in the rat liver

Summary

The effect of dieldrin on the bound and free activity of cathepsin, acid ribonuclease, acid phosphatase and aryl sulphatase has been investigated. Administration of dieldrin increased the activity of free cathepsin, acid ribonuclease, and acid phosphatase in rat liver whereas it did not affect the activity of aryl sulphatase. This indicates that dieldrin labilizes the lysosomes.

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Taken in part from a thesis submitted by KKK to the Faculty of Medical Sciencs, University of Delhi for the degree of Doctor of Philosophy, May 1976.

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Kohli, K.K., Siddiqui, F.A. & Venkitasubramanian, T.A. Effect of dieldrin on the stability of lysosomes in the rat liver. Bull. Environ. Contam. Toxicol. 18, 617–623 (1977). https://doi.org/10.1007/BF01684009

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Keywords

  • Acid Phosphatase
  • Lysosomal Enzyme
  • Dieldrin
  • Free Activity
  • Carbon Tetra