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Quality of life in patients with ovarian cancer: Current state of research

Supportive Care in Cancer volume 4, pages 169–179 (1996)Cite this article

Abstract

Ovarian cancer is the most malignant cancer in women, where it is the fifth leading cause of cancer-related death. The disease and its treatment have considerable effects on the quality of life of patients with this cancer. This study reviews existing literature on quality of life in patients with ovarian cancer to demonstrate the importance of the topic, to comment on improvements achieved and to consider their implications for the implementation of optimal treatment. A literature search was carried out through MEDLINE and of published papers on quality of life in patients with ovarian cancer from 1976 to 1994. Twenty papers have been reviewed, of which, 10 were treatment-related assessments of quality of life and the remaining 10 dealt with different topics including psychometric issues in measuring health-related quality of life. Twenty-four instruments were employed to measure quality of life. Of these, the Rotterdam Symptom Checklist (RSCL) and The European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) were found to be the most appropriate. Although meta-analysis of results is impossible, it appears that debulking surgery followed by platinum-based chemotherapy could improve both quality of life and survival. In addition to effective and efficient treatment, psychological counselling, palliative and home care, nutritional support and pain relief are the most important areas for improving quality of life of patients with ovarian cancer. Knowledge and insight into the quality of life of patients with ovarian cancer are still limited, and a large carefully planned international study is required. Use of existing standard measures is preferable and agreement should be reached on a selected single instrument.

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References

  1. Aaronson NK, Beckmann JH (eds) (1987) The quality of life of cancer patients. Raven Press, New York

    Google Scholar 

  2. Aaronson NK, Ahmedzai S, Bergman B, et al (1993) The European Organisation for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376

    PubMed  Google Scholar 

  3. Anderson B (1994) Quality of life in progressive ovarian cancer. Gynaecol Oncol 55: S151-S155

    Google Scholar 

  4. Austoker J (1994) Screening for ovarian, prostatic, and testicular cancers. Br Med J 309:315–320

    Google Scholar 

  5. Black RJ, Sharp L, Kendrick SW (1993) Trends in cancer survival in Scotland: 1968–1990. Information and Statistics Division—NHS in Scotland, Edinburgh, p 44

    Google Scholar 

  6. Bliss JM, Selby PJ, Robertson B, Powles TJ (1992) A method for assessing the quality of life of cancer patients: replication of the factor structure. Br J Cancer 65:961–966

    PubMed  Google Scholar 

  7. Blythe JG, Wahl TP (1982) Debulking surgery: does it increase the quality of survival? Gynaecol Oncol 14:396–408

    Google Scholar 

  8. Bos-Branolte G, Zielstra EM, Rijshouwer YM, Duivenvoorden HJ (1988) Psychotherapy in patients cured of gynaecologic cancers. Recent Results Cancer Res 108:277–288

    PubMed  Google Scholar 

  9. Boyd NF, Selby PJ, Sutherland HJ, Hogg S (1988) Measurement of the clinical status of patients with breast cancer: evidence for the validity of self assessment with linear analogue scales. J Clin Epidemiol 41:243–250

    PubMed  Google Scholar 

  10. Coates A, Dillenbeck CF, McNeil DR, et al (1983) On the receiving end. II. Linear analogue self-assessment (LASA) in evaluation of aspect of the quality of life of cancer patients receiving therapy. Eur J Cancer Clin Oncol 19:1633–1637

    PubMed  Google Scholar 

  11. Coates A, Abraham S, Kaye SB, et al (1983) On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19:203–208

    PubMed  Google Scholar 

  12. Crowther ME, Corney RH, Shepherd JH (1994) Psychosexual implications of gynaecological cancer. Talk about it. Br Med J 308:869–870

    Google Scholar 

  13. Fallowfield LJ (1993) Quality of life measurement in breast cancer. J R Soc Med 86:10–12

    PubMed  Google Scholar 

  14. Fayers PM, Jones DR (1983) Measuring and analysing quality of life in cancer clinical trials: a review. Statist Med 2:429–446

    Google Scholar 

  15. Furst CJ, Johansson S, Fredikson M, Hursti T, Steineck G, Peterson C (1992) Control of cisplatin induced emesis — a multidisplinary intervention strategy. Med Oncol Tumour Pharmacother 9:81–86

    Google Scholar 

  16. Ganz PA (1994) Quality of life and the patient with cancer: individual and policy implications. Cancer 74:1445–1452

    PubMed  Google Scholar 

  17. Ganz PA, Haskell CM, Figlin RA, La Soto N, Siau J (1988) Estimating the quality of life in clinical trial of patients with metastatic lung cancer using the Karnofsky Performance Status and the Functional Living Index-Cancer. Cancer 61:849–856

    PubMed  Google Scholar 

  18. Gillis CR, Hole DJ, Still RM, Davis J, Kaye SB (1991) Medical audit, cancer registration, and survival in ovarian cancer. Lancet 337:611–612

    Google Scholar 

  19. Gotay CC, Moore TD (1992) Assessing quality of life in head and neck cancer. Qual Life Res 1:5–17

    PubMed  Google Scholar 

  20. Granai CO (1992) Ovarian cancer — unrealistic expectations. N Engl J Med 373:194–200

    Google Scholar 

  21. Guidozzi F (1993) Living with ovarian cancer. Gynaecol Oncol 50:202–207

    Google Scholar 

  22. Haes JCJM de, Knippenberg FCE van (1985) The quality of life of cancer patients: a review of the literature. Soc Sci Med 20:809–817

    PubMed  Google Scholar 

  23. Haes JCJM de, Raatgever JW, Burg MEL ven der, Hamersma E, Neijt JP (1987) Evaluation of the quality of life of patients with advanced ovarian cancer treated with combination chemotherapy. In: Aaronson NK, Beckman J (eds) The quality of life of cancer patients. Raven Press, New York, pp 215–226

    Google Scholar 

  24. Haes JCJM de, Knippenberg FCE van, Nejit JP (1990) Measuring psychological and physical distress in cancer patients: structure and application of Rotterdam Symptom Checklist. Br J Cancer 62:1034–1038

    PubMed  Google Scholar 

  25. Hays RD, Anderson R, Revicki D (1993) Psychometric consideration in evaluating health-related quality of life. Qual Life Res 2:441–449

    PubMed  Google Scholar 

  26. Hole D, Gillis CR (1993) Use of cancer registry data to evaluate the treatment of ovarian cancer on hospital basis. Health Rep 5:117–119

    PubMed  Google Scholar 

  27. Hopwood P, Stephens RJ, Machin D (1994) Approaches to the analysis of quality of life data: experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial. Qual Life Res 3:339–352

    PubMed  Google Scholar 

  28. Janicke F, Holscher M, Kuhn W, et al (1992) Radical surgical procedure improves survival time in patients with recurrence ovarian cancer. Cancer 70:2129–2136

    PubMed  Google Scholar 

  29. Jenkinson C (1994) Quality of life measurement: does it have a place in routine clinical assessment? J Psychsom Res 38:377–381

    Google Scholar 

  30. Junor EJ, Hole DJ, Gillis CR (1994) Management of ovarian cancer: referral to a multidisciplinary team matters. Br J Cancer 70:363–370

    PubMed  Google Scholar 

  31. King LA, Carson LF, Konstantinides N, et al (1993) Outcome assessment of home parenteral nutrition in patients with gynecologic malignancies: what have we learned in a decade of experience? Gynaecol Oncol 51:377–382

    Google Scholar 

  32. Levi F, Franceschi S, La Vecchia C, Ruzicka J, Gloor E, Randimbison L (1993) Epidemiologic pathology of ovarian cancer from the Vaud Cancer Registry, Switzerland. Ann Oncol 4:289–294

    PubMed  Google Scholar 

  33. Maguire P, Selby P (1989) Assessing quality of life in cancer patients. Br J Cancer 60:437–440

    PubMed  Google Scholar 

  34. Malone M, Harris AL, Luscombe DK (1994) Assessment of the impact of cancer on work, recreation, home management and sleep using a general health status measure. J R Soc Med 87:386–389

    PubMed  Google Scholar 

  35. Markman M (1994) Follow-up of the asymptomatic patient with ovarian cancer. Gynaecol Oncol 55: S134-S137

    Google Scholar 

  36. McDowell I, Newell C (1987) Measuring health: a guide to rating scales and questionnaires. Oxford University Press, New York, p 213

    Google Scholar 

  37. Mermelstein HT, Lesko L (1992) Depression in patients with cancer. Psycho-Oncology 1:199–215

    Google Scholar 

  38. Montazeri A (1994) A study on quality of life in patients with ovarian cancer (research proposal). West of Scotland Health Services Research News 12:6

    Google Scholar 

  39. Olschewski M, Schulgen G, Schumacher M, Altman DG (1994) Quality of life assessment in clinical cancer research. Br J Cancer 70:1–5

    PubMed  Google Scholar 

  40. Osoba D (ed) (1991) Effect of cancer on quality of life. CRC Press, Boca Raton, Fla

    Google Scholar 

  41. Osoba D, Zee B, Pater J, Warr D, Kaizer L, Latreille J (1994) Psychometric properties and responsiveness of the EORTC Quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer. Qual Life Res 3:353–364

    PubMed  Google Scholar 

  42. Ovesen BL, Allingstrup L, Hannibal J, Mortensen EL, Hansen OP (1993) Effect of dietary counselling on food intake, body weight, response rate, survival, and quality of life in cancer patients undergoing chemotherapy: a prospective randomised study. J Clin Oncol 11:2043–2049

    PubMed  Google Scholar 

  43. Ovesen L, Hannibal J, Mortensen EL (1993) The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast, and ovary. Nutr Cancer 19:159–167

    PubMed  Google Scholar 

  44. Ozols RF, Young RC (1991) Ovarian cancer: where to next? Semin Oncol 18:307–310

    PubMed  Google Scholar 

  45. Ozols RF, Young RC (1991) Chemotherapy of ovarian cancer. Semin Oncol 18:222–232

    PubMed  Google Scholar 

  46. Payne SA (1992) A study of quality of life in cancer patients receiving palliative chemotherapy. Soc Sci Med 35:1505–1509

    PubMed  Google Scholar 

  47. Petru E, Sevin BU, Averette HE, Koechli OR, Hilsenbeck S (1991) Long-term survival in stage II and IV ovarian cancer. Arch Gynaecol Obstet 249:87–93

    Google Scholar 

  48. Portenoy RK, Thaler HT, Kornblith AB, et al (1994) The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 30:1326–1336

    Google Scholar 

  49. Portenoy RK, Thaler HT, Kornblith AB, et al (1994) Symptom prevalence, characteristics and distress in a cancer population. Qual Life Res 3:183–189

    PubMed  Google Scholar 

  50. Portenoy RK, Kornblith AB, Wong G, Vlamis V, Lepore JM, Loseth DB (1994) Pain in ovarian cancer patients: prevalence, characteristics, and associated symptoms. Cancer 74:907–915

    PubMed  Google Scholar 

  51. Roberts CS, Rossetti K, Cone D, Cavanagh D (1992) Psychosocial impact of gynecologic cancer: a descriptive study. J Psychosoc Oncol 10(1):99–109

    Google Scholar 

  52. Schipper H, Clinch J, McMurray A, Levitt M (1984) Measuring the quality of life of cancer patients-the Functional Living Index-Cancer: development and validation. J Clin Oncol 2:472–483

    PubMed  Google Scholar 

  53. Spitzer WO, Dobson AJ, Hall J, et al (1981) Measuring the quality of life of cancer patients: a concise QL-Index for use by physicians. J Chronic Dis 34:585–597

    PubMed  Google Scholar 

  54. Tchekmedyian NS, Call DF (eds) (1990) Quality of life in current oncology practice and research. Oncology 4 (special issue)

  55. Walczak JR, Brady M (1991) Comparison of quality of life (QOL) in ovarian cancer patients participating in a national cooperative group phase III randomised trial (abstract). Proc ASCO 10: A1185

    Google Scholar 

  56. Warde P, Strugeon JF, Fine S, Hogg SA, Boyd NF (1984) Quality of life assessment in patients with carcinoma of the ovary (abstract). Proc ASCO 3: C-266

  57. Watson M, Law M, Maguire GP, et al (1992) Further development of a quality of life measure for cancer patients: the Rotterdam Symptom Checklist (revised). Psycho-Oncology 1:35–44

    Google Scholar 

  58. Willemse PB, Lith J van, Mulder NH, et al (1990) Risk and benefits of cisplatin in ovarian cancer. A quality-adjusted survival analysis. Eur J Cancer 26:345–352

    PubMed  Google Scholar 

  59. Willemse PB, Assendelft PH van, Fontein DL, Kloppenburg M, Boonstra H, Vries EG de (1991) Carboplatin in the treatment of ovarian carcinom; as effective and less toxic in comparison with cisplatin (in Dutch). Ned Tijdschr Geneeskd 135:1588–1592

    PubMed  Google Scholar 

  60. Williams C (1992) Ovarian and cervical cancer. Br Med J 304:1501–1504

    Google Scholar 

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Affiliations

  1. Department of Public Health, University of Glasgow, 2 Lilybank Gardens, G12 8RZ, Glasgow, UK

    Ali Montazeri & James McEwen

  2. West of Scotland Cancer Surveillance Unit, Ruchill Hospital, Glasgow, UK

    Charles R. Gillis

Authors
  1. Ali Montazeri
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  2. James McEwen
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  3. Charles R. Gillis
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Montazeri, A., McEwen, J. & Gillis, C.R. Quality of life in patients with ovarian cancer: Current state of research. Support Care Cancer 4, 169–179 (1996). https://doi.org/10.1007/BF01682336

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  • DOI: https://doi.org/10.1007/BF01682336

Key words

  • Quality of life
  • Ovarian cancer
  • Optimal treatment
  • Quality of life measures