Intervertebral disc degeneration - an autopsy study

  • V. L. Fornasier
  • G. Garaffo
  • L. Denaro
  • V. Denaro
Original articles


This is an autopsy analysis of 126 thoracolumbar spines. Extensive histomorphological examination identified microscopic changes in the nucleus and annulus fibrosus before any gross or radiological changes were evident. Histomorphological evidence of microavulsion of the attachment of the annulus fibrosus from its mooring at the margin of the cartilaginous endplate of the vertebral body suggests that forces (compression, distraction, rotation) applied during movement are contributing factors to the pathogenesis of degenerative disc disease.

Key words

Intervertebral disc Degeneration Spine 


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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • V. L. Fornasier
  • G. Garaffo
    • 1
  • L. Denaro
    • 2
  • V. Denaro
    • 3
  1. 1.Staff SurgeonGiarre HospitalCatania, SicilyItaly
  2. 2.Orthopaedic Pathology, Laboratory of Bone and Joint Pathology, Department of PathologyWellesley Central Site, St. Michael's Hospital, University of TorontoCanada
  3. 3.Department of Orthopaedic Surgery, Campus Bio MedicoFree University of RomeRomaItaly

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