Summary
Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring closure reaction by condensation of a nitroso function with an activated methylene group. The selected reaction sequence allows the production of a highly diverse small-molecule combinatorial compound library.
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Heizmann, G., Eberle, A.N. Xanthines as a scaffold for molecular diversity. Mol Divers 2, 171–174 (1997). https://doi.org/10.1007/BF01682205
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DOI: https://doi.org/10.1007/BF01682205