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Adhesive receptors expressed by tumor cells and platelets: novel targets for therapeutic anti-metastatic strategies

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Abstract

In vitro andin vivo studies have demonstrated that adhesive interactions between tumor cells and platelets may play a central role in the metastatic process. Ultrastructural studies have demonstrated that platelets appear to enhance the development of arrested tumor emboli into a secondary metastatic colony. Platelet adhesive glycoprotein receptors and their immunorelated counterparts expressed by tumor cells participate in tumor-induced platelet aggregation, which may be an early step in the development of a metastatic lesion. Platelet anti-adhesive agents have been demonstrated to reduce metastases in rodent models. Although tumor adhesive glycoproteins have yet to be fully characterized, specific inhibition of their functional sites could constitute a forthcoming strategy for effective inhibition of metastases.

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  1. Department of Oncology, Montefiore Medical Center Hospital, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, New York, USA

    Lesle Oleksowicz & Janice P. Dutcher

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Oleksowicz, L., Dutcher, J.P. Adhesive receptors expressed by tumor cells and platelets: novel targets for therapeutic anti-metastatic strategies. Med Oncol 12, 95–102 (1995). https://doi.org/10.1007/BF01676709

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