Skip to main content
Log in

Histochemistry of elastic and related fibres in the human eye in health and disease

  • Review
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

Summary

Although the presence of mature elastic fibres in the sclera, trabecular meshwork and Bruch's membrane of the human eye has been recognized for many years, it is only latterly that the existence of the elastic-related fibres oxytalan and elaunin has been appreciated. The microfibrillar component of elastic, oxytalan, which is present in several ocular structures in infancy, can either mature to fully-developed elastic tissue or, as in the cornea, disappear in subsequent years. Deposition of elastic fibres, particularly the incomplete forms, can occur in the post-developmental period in a variety of disease states but the stimulus and functional significance in most situations is obscure. The evidence suggests, however, that the capacity to form elastic-related tissue is not confined to any one cell type.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • ALEXANDER, R. A. & GARNER, A. (1977) Oxytalan fibre formation in the cornea. A light and electron microscopical study.Histopathol. 1 189–99.

    Google Scholar 

  • ALEXANDER, R. A. & GARNER, A. (1983) Elastic and precursor fibres in the normal human eye.Exp. Eye Res. 36 305–15.

    Google Scholar 

  • ALEXANDER, R. A., GRIERSON, I. & GARNER, A. (1981) Oxytalan fibres in Fuchs' endothelial dystrophy.Arch. Ophthal. 99 1622–7.

    Google Scholar 

  • CARMICHAEL, G. G. & FULLMER, H. M. (1966) The fine structure of the oxytalan fibre.J. Cell. Biol. 28 33–6.

    Google Scholar 

  • COTTA-PEREIRA, G., GEURRA-RODRIGO, F. & BITTENCOURT-SAMPAIO, S. (1976). Oxytalan, elaunin and elastic fibres in the human skin.J. Invest. Dermatol. 66 143–8.

    Google Scholar 

  • FAHRENBACH, W. H., SANDBERG, L. B. & CLEARY, E. G. (1966) Ultrastructural studies on early elastogenesis.Anat. Rec. 155 563–76.

    Google Scholar 

  • FULLMER, H. M. & LILLIE, R. D. (1958) The oxytalan fibre: a previously undescribed connective tissue fibre.J. Histochem. Cytochem. 6 425–30.

    Google Scholar 

  • FULLMER, H. M., SHEETZ, J. H. & NARKATES, A. T. (1974) Oxytalan connective tissue fibres: a review.J. Oral Pathol. 3 291–316.

    Google Scholar 

  • GARNER, A. & ALEXANDER, R. A. (1981) Pre-elastic (oxytalan) fibres in corneal pathology. InProceedings of the VIth Congress of the European Society of Ophthalmology, Brighton, 1980 (Edited by Trevor-Roper, H.) pp. 213–6. London: Royal Society of Medicine/Academic Press.

    Google Scholar 

  • GARNER, A. & ALEXANDER, R. A. (1984) Pseudoexfoliative disease: histochemical evidence of an affinity with zonular fibres.Br. J. Ophthal. 68 574–80.

    Google Scholar 

  • GASS, J. D. M. & CLARKSON, J. G. (1973) Angioid streaks and disciform macular detachment in Paget's disease (osteitis defornans)Am. J. Ophthal. 75 576–86.

    Google Scholar 

  • GAWLIK, Z. (1965) Morphological and morphochemical properties of the elastic system in the motor organ of man.Folia Histochem. Cytochem. 3 233–51.

    Google Scholar 

  • GREENLEE, T. K., ROSS, R. & HARTMAN, J. L. (1966) The fine structure of elastic fibres.J. Cell Biol. 30 59–71.

    Google Scholar 

  • JENSEN, O. A. (1977) Bruch's membrane in pseudoxanthoma elasticum.Albrecht von Graefes Arch. Ophthal. 203 157–66.

    Google Scholar 

  • KRAUHS, J. M. (1983) Microfibrils in the aorta.Conn. Tiss. Res. 11 153–67.

    Google Scholar 

  • NOOR-SUNBA, M. S., RAHI, A. H. S., GARNER, A., ALEXANDER, R. A. & MORGAN, G. (1980) Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.Br. J. Ophthal. 64 867–74.

    Google Scholar 

  • RAVIOLA, G. (1971) The fine structure of the ciliary zonule and ciliary epithelium, with special regard to the organization and insertion of the zonular fibrils.Invest. Ophthal. Vis. Sci. 10 851–69.

    Google Scholar 

  • ROSS, R. & BORNSTEIN, P. (1969) Elastic fibres. I. Separation and partial characterization of its macromolecular components.J. Cell Biol. 40 366–81.

    Google Scholar 

  • SCHWARTZ, E., GOLDFISCHER, S., COLTOFF-SCHILLER, B. & BLUMENFELD, O. (1985) Extracellular matrix microfibrils are composed of core proteins coated with fibronectin.J. Histochem. Cytochem. 33 268–74.

    Google Scholar 

  • SHEETZ, J. H., FULLMER, H. M. & NARKATES, A. J. (1973) Oxytalan fibres: identification of the same fibre by light and electron microscopy.J. Oral Pathol. 2 254–63.

    Google Scholar 

  • STREETEN, B. W., DARK, A. J. & BARNES, C. W. (1984) Pseudoexfoliative material and oxytalan fibres.Exp. Eye Res. 38 523–31.

    Google Scholar 

  • STREETEN, B. W. & LICARI, P. A. (1983) The zonules and the elastic microfibrillar system in the ciliary body.Invest. Ophthal. Vis. Sci. 24 667–81.

    Google Scholar 

  • STREETEN, B. W., LICARI, P. A., MARUCCI, A. A. & DOUGHERTY, R. M. (1981). Immunohistochemical comparison of ocular zonules and the microfibrils of elastic tissue.Invest. Ophthal. Vis. Sci. 21 130–5.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garner, A., Alexander, R.A. Histochemistry of elastic and related fibres in the human eye in health and disease. Histochem J 18, 405–412 (1986). https://doi.org/10.1007/BF01675332

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01675332

Keywords

Navigation