Summary
The effects of pimozide (a dopamine receptor blocker) and bromocriptine (a dopamine receptor agonist) on the mitotic incidence in the anterior pituitary in male rats was investigated. It was shown that pimozide enhanced anterior pituitary mitotic activity in male rats. Bromocriptine, in turn, suppressed anterior pituitary cell proliferation in estradiol-treated male rats. A dopaminergic control of anterior pituitary mitotic activity is suggested.
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References
Boyd, A. E., Reichlin, S. Galactorrhea-amenorrhea, brom-ergocryptine and the dopamine receptor. New Engl. J. Med.293, 451–452 (1975).
Brown, G. M., Seeman, P., Lee, T. Dopamine/neuroleptic receptors in basal hypothalamus and pituitary. Endocrinol.99, 1407–1410 (1976).
Fuxe, K., Hökfelt, T., Nilsson, O. Castration, sex hormones and tuberoinfundibular dopamine neurons. Neuroendocrinol.5, 107–120 (1969).
Gnodde, H. P., Schulling, G. A. Involvement of catecholaminergic and cholinergic mechanism in the pulsatile release of LH in the long-term ovariectomized rat. Neuroendocrinol.20, 212–223 (1976).
Herlant, M. Etude critique de deux techniques nouvelles destinées à mettre en évidence les différentes catégories cellulaires presentes dans la glande pituitaire. Bull. Micr. appl.10, 37–44 (1960).
Jori, A., Dolfini, E. Modification of striatal dopamine levels by steroid contraceptive drugs in mice and rats. Neuroendocrinol.21, 74–78 (1976).
Krulich, L.: Central monoamines and TSH secretion in the rat. V. Int. Congress of Endocrinology (Abstracts), Hamburg, 126 (1976).
Lloyd, H. M., Meares, J. D., Jacobi, J. Effects of oestrogen and bromocryptine onin vivo secretion and mitosis in prolactin cells. Nature255, 497–498 (1975).
Mac Leod, R. M. Regulation of prolactin secretion. In: Frontiers in Neuroendocrinology (Martini, L., Ganong, W. F., eds), pp. 169–194. New York: Raven Press. 1976.
Mac Leod, R. M., Lehmeyer, J. E. Suppression of pituitary tumor growth and function by ergot alkaloids. Cancer Res.33, 849–855 (1973).
Maurer, R. A., Gorski, J. Effects of estradiol −17 beta and pimozide on prolactin synthesis in male and female rats. Endocrinol.101), 76–84 (1977).
Müller, E. E. Brain monoamines participation in the control of GH secretion in different animal species. In: Frontiers in Catecholamine Research (Usdin, E., Snyder, S., eds.), pp. 835–841. New York: Pergamon Press. 1973.
Penny, R. J., Thody, A. J., Tilders, F. J., Smelik, P. G.: Effect of dopamine receptor blockers on pituitary and plasma melanocyte stimulating hormone levels in the rat. J. Endocrinol.72, 27P (1977).
Rychter, J., Stępień, H. Effects of pimozide and bromocriptine on proliferation of the pituitary pars intermedia cells. J. Endocrinol.75, 443–444 (1977).
Schneider, H. P., McCann, S. M. Estradiol and the neuroendocrine control of LH releasein vitro. Endocrinol.87, 330–338 (1970).
Schreiber, V., Pribyl, T. Dopaminergic control of adenohypophysial weight and serum ceruloplasmin level in rats. Neuroendocrinol.21, 58–67 (1976).
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This paper was supported by the Polish Academy of Sciences, grant No. 10.4.2.01.5.5.
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Stępień, H., Wolaniuk, A. & Pawlikowski, M. Effects of pimozide and bromocriptine on anterior pituitary cell proliferation. J. Neural Transmission 42, 239–244 (1978). https://doi.org/10.1007/BF01675313
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DOI: https://doi.org/10.1007/BF01675313