Skip to main content
SpringerLink
Log in

Thyroid stimulating and gonadotrophic hormones in pituitary adenomas without clinical or serological abnormality

  • Papers
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

Summary

Forty-three chromophobe adenomas have been examined immunocytochemically for their hormonal content. Twelve cases with full pre-operative normal serum hormonal levels were found to have many positive cells within the tumour for thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). The specificity of the immunoreactive product within the tissue was checked by immunoabsorption. It is suggested that a non-secreted biologically inactive glycoprotein hormone is produced by tumour clones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • CHILDS, G. V., HUTSON, J. C. & BAUER, T. W. (1981) Immunocytochemical detection of hormones at target binding sites. InDiagnostic Immunohistochemistry (edited by STERNBERG, S. S. and DE LELLIS, R. A.) pp. 165–77. New York: Masson.

    Google Scholar 

  • CORENBLUM, B., SIREK, A. M. T., HORVATH, E., KOVACS, K. & EZRIN, C. (1976) Human mixed somatotrophic and lactotrophic pitiutary adenomas.J. Clin. Endocrinol. Metab. 42 857–63.

    Google Scholar 

  • ESIRI, M. M., ADAMS, C. B. T., BURKE, C. & UNDERDOWN, R. (1983) Pituitary adenomas: immunohistology and ultrastructural analysis of 118 tumors.Acta neuropathol. 62, 1–14.

    Google Scholar 

  • HEITZ, P. U.. (1979) Multihormonal pituitary adenomas.Hormone Res. 10 1–13.

    Google Scholar 

  • KOURIDES, I. A., WEINTRAUB, B. D., ROSEN, S. W., RIDGEWAY, E. C., KLIMAN, B. & MALOOF, F., (1976) Secretion of alpha subunit of glycoprotein hormones by pituitary adenomas.J. Clin. Endocrinol. Metab. 43, 97–106.

    Google Scholar 

  • KOVACS, K., HORVATH, E. & RYAN, N. (1981) Immunocytology of the human pituitary. InDiagnostic Immunohistochemistry (edited by STERNBERG, S. S. and DE LELLIS, R. A.) pp. 17–35. New York: Masson.

    Google Scholar 

  • KOVACS, K., HORVATH, E., RYAN, N. & EZRIN, C. (1980). Null cell adenoma of the human pituitary.Virchows arch. A. (Path. Anat. Histol.)387 165–74.

    Google Scholar 

  • KOVACS, K., HORVATH, E., VAN LOON, G. R., REWCASTLE, N. B., EZRIN, C. & ROSENBLOOM, A. A., (1978) Pituitary adenomas associated with elevated blood follicle-stimulating hormone levels: a histologic immunocytologic, and electron microscopic study of two cases.Fertil. Steril. 29, 622–8.

    Google Scholar 

  • MARTINEZ, A. J., LEE, A., MOOSSY, J. & MAROON, J. C. (1980) Pituitary adenomas: clinicopathological and immunohistochemical study.Ann. Neurol. 7, 24–36.

    Google Scholar 

  • MIURA, M., MATSUKADO, Y., KODAMA, T. & MIHARA, Y. (1985) Clinical and histopathological characteristics of gonadotrophin-producing pituitary adenomas.J. Neurosurg. 62 376–82.

    Google Scholar 

  • SNYDER, P. J., JOHNSON, J. & MUZYKA, R. (1980) Abnormal secretion of glycoproteinα-subunit and follicle-stimulating hormone (FSH)β-subunit in men with pituitary adenomas and FSH hypersecretion.J. Clin. Endocrinol. Metab. 51 579–84.

    Google Scholar 

  • STERNBERGER, L. A., (1979)Immunocytochemistry, 2nd edn. pp. 104–69. New York: John Wiley and Sons.

    Google Scholar 

  • STERNBERGER, L. A., HARDY, P. H., CUCULIS, J. J. & MEYER, H. G. (1970) The unlabelled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.J. Histochem. Cytochem. 18, 315–33.

    Google Scholar 

  • TAKUECHI, J., HANDA, H., SUDA, K., & ASO, T. (1980)In vitro secretion of follicle-stimulating hormone by pituitary chromophobe adenomas.Surg. Neurol. 14 303–9.

    Google Scholar 

  • TOLIS, G., BIRD, C., BERTRAND, G., MCKENZIE, J. M. & EZRIN, C. (1978) Pituitary hyperthyroidism.Am. J. Med. 64 177–81.

    Google Scholar 

  • TROUILLAS, J., GIROD, C., SASSOLAS, G., CLAUSTRAT, B., LHÉRITIER, M., DUBOIS, M. P. & GOUTELLE, A. (1981) Human pituitary gonadotropic adenoma; histological, immunocytochemical, and ultrastructural and hormonal studies in eight cases.J. Pathol. 135 315–36.

    Google Scholar 

  • ZIMMERMAN, E. A., DEFENDINI, R. & FRANTZ, A. G. (1974) Prolactin and growth hormone in patients with pituitary adenomas: a correlative study of hormone in tumor and plasma by immunoperoxidase technique and radioimmunoassay.J. Clin. Endocrinol. Metab. 38, 577–85.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Brain Tumour Research Laboratory, University of Birmingham, Midland Centre for Neurosurgery and Neurology, B67 7JX, Warley, Birmingham, UK

    Edward Hitchcock & Christine S. Morris

Authors
  1. Edward Hitchcock
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine S. Morris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hitchcock, E., Morris, C.S. Thyroid stimulating and gonadotrophic hormones in pituitary adenomas without clinical or serological abnormality. Histochem J 18, 317–320 (1986). https://doi.org/10.1007/BF01675209

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01675209

Keywords

Search

Navigation