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Hormone replacement therapy in the prevention and treatment of osteoporosis

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References

  1. Marcus R, Feldman D. Osteoporosis. In: Kelsey J, editors. New Yorks: Academic Press, 1996:1373

    Google Scholar 

  2. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res 1994;9:1137–41.

    Google Scholar 

  3. Kanis JA, and the WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteopor osis: synopsis of a WHO report. Osteoporosis Int 1994;4:368–81.

    Google Scholar 

  4. Melton LJ III, Chrischilles EA, Copper C, Lane AW, Riggs BL. How many women have osteoporosis? J Bone Miner Res 1992;7:1005–10.

    Google Scholar 

  5. Smith DM, Khairi MRA, Johnston CC. The loss of bone mineral with ageing and its relationship to risk fracture. J Clin Invest 1975;56:311–8.

    Google Scholar 

  6. Hansen MA, Kirsten O, Riis BJ, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 years study. BMJ 1991;303:961–4.

    Google Scholar 

  7. Nordin BEC, Need AG, Chatterton BE, Horowitz M, Morris HA. The relative contributions of age and years since menopause to postmenopausal bone loss. J Clin Endocrinol Metab 1989;70:83–8.

    Google Scholar 

  8. Heaney RP, Recker RR, Saville PD. Menopausal changes in bone remodelling. J Lab Clin Med 1978;92:964–70.

    Google Scholar 

  9. Recker RR, Saville PD, Heaney RP. Effects of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann Intern Med 1977;87:649–55.

    Google Scholar 

  10. Nachtigall NE, Nachtigall RH, Nachtigall RD, Beckman EM. Estrogen replacement therapy: a 10-year prospective study in the relationship to osteoporosis. Obstet Gynecol 1979;53:277–81.

    Google Scholar 

  11. Christiansen C, Christiansen MS, McNair P, Hagen C, Stocklund KE, Transbol I. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest 1980;10:273–9.

    Google Scholar 

  12. Lindsay R, Hart DM, Forrest C, Baird C. Prevention of spinal osteoporosis in oophorectomized women. Lancet 1980;2:1151–3.

    Google Scholar 

  13. Harris ST, Genant HK, Baylink DJ, Gallagher JC, Karp SK, McConnel MA, Green EM, Stoll RW. The effects of estrone (Ogen) on spinal bone density of postmenopausal women. Arch Intern Med 1981;151:181–4.

    Google Scholar 

  14. Genant HK, Cann CE, Ettinger B, Gordon GS. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 1982;97:699–705.

    Google Scholar 

  15. Hillard TC, Whiteroft SJ, Marsh MS, Ellerington MC, Lees B, Whitehead MI, Stevenson JC. Long term effects of transdermal and oral hormone replacement therapy on post-menopausal bone loss. Osteoporosis Int 1994;4:341–8.

    Google Scholar 

  16. Gallagher JC, Baylink D. Effects of estrone sulfate on bone mineral density of the femoral neck and spine. J Bone Miner Res [Suppl] 1990;5:S275.

    Google Scholar 

  17. Lindsay R, Hart DM, MacLean A, Clark AC, Kraszewski A, Garwood J. Bone response to termination of estrogen treatment. Lancet 1978;1:1325–7.

    Google Scholar 

  18. Christiansen C, Christiansen MS, Transbol I. Bone mass in postmenopausal women after withdrawal of estrogen/gestagen replacement therapy. Lancet 1981;1:459–61.

    Google Scholar 

  19. Christiansen C, Christiansen MS, Larsen NE, Transbol I. Patho-physiological mechanisms of estrogen effect on bone metabolism: dose-response relationships in early postmenopausal women. J Clin Endocrinol Metab 1982;55:1124–30.

    Google Scholar 

  20. Lindsay R, Hart DM, Clark DM. The minimum effective dose of estrogen for prevention of postmenopausal bone loss. Obstet Gynecol 1984;63:759–63.

    Google Scholar 

  21. Chetkowski RJ., Meldrum DR, Steingold KA, et al. Biologic effects of transdermal estradiol. N Engl J Med 1986;1160-1.

  22. Riis BJ, Thomsen K, Strom V, Christiansen C. The effect of percutaneous estradiol and progesterone on postmenopausal bone loss. Am J Obstet Gynecol 1987;156:61–5.

    Google Scholar 

  23. Stevenson JC, Cust MP, Gangar KF, Hillard TC, Lees B, Whitehead MI. Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women. Lancet 1990;335:265–9.

    Google Scholar 

  24. Field CS, Ory SJ, Wahner HW, Herrmann RR, Judd HL, Riggs BL. Preventive effects of transdermal 17β-estradiol on osteoporotic changes after surgical menopause: a two-year placebo controlled trial. Am J Obstet Gynecol 1993;168:114–21.

    Google Scholar 

  25. Tremollières F, Pouilles JM, Louvet JP, Ribot C. Prevention effects on postmenopausal bone loss of percutaneous 17β-estradiol in early and late menopause. In: Christiansen C, Overgaard K, editors. Osteoporosis. Copenhagen: Osteopress, 1990:1910–16.

    Google Scholar 

  26. Johansen S, Riis BJ, Delmas PD, Christiansen C. Plasma BGP: an indicator of spontaneous bone loss and of the effect of estrogen treatment in post-menopausal women. Eur J Clin Invest 1988;18:191–5.

    Google Scholar 

  27. Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD. Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab 1991;72:367–73.

    Google Scholar 

  28. Prestwood KM, Pilbeam CC, Burleson JA, Woodiel FN, Delmas PD, Deftos LJ, Raisz LG. The short term effects of conjugated estrogen on bone turnover in older women. J Clin Endocrinol Metab 1994;79:366–71.

    Google Scholar 

  29. Lufkin EG, Wahner HW, O'Fallon WM, Hodgson SF, Kotowicz MA, Lane AW, Judd HL, Caplan RH, Riggs BL. Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med 1992;117:1–9.

    Google Scholar 

  30. Lindsay R, Tohme J. Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet Gynecol 1990;76:1–6.

    Google Scholar 

  31. Quigley MET, Martin PL, Burnier AM. Estrogen therapy arrests bone loss in elderly women. Am J Obstet Gynecol 1987;156:1516–23.

    Google Scholar 

  32. Christiansen C, Riis BJ. 17β-Estradiol and continuous noresthisterone: a unique treatment for established osteoporosis in elderly women. J Clin Endocrinol Metab 1990;71:836–41.

    Google Scholar 

  33. Lindsay R, Hart DM, Abdalla M, Al-Azzawi F. Inter-relation-ship of bone loss and its prevention, and fracture expression. In: Christiansen C, Johansen JS, Riis BJ. editors, Osteoporosis. Copenhagen: Osteopress, 1987;508–12.

    Google Scholar 

  34. Sornay-Rendu E, Arlot M, Garnero P, Delmas PD. The efficacy of long term prevention of osteoporosis by hormone replacement therapy (HRT) is variable according to skeletal sites: the OFELY study. J Bone Miner Res 1995;S357.

  35. Felson DT, Zhang Y, Hannan MT, Kiel DP, Wilson WF, Anderson JJ. The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med 1993;329:1141–6.

    Google Scholar 

  36. Gordan GS, Picchi J, Roof BS. Antifracture efficacy of long term estrogens for osteoporosis. Trans Assoc Am Physic 1973;86:326–32.

    Google Scholar 

  37. Ettinger B, Genant HK, Cann CE. Long term estrogen replacement therapy. I. Metabolic effects. Am J Obstet Gynecol 1979;133:525–36.

    Google Scholar 

  38. Hutchinson TA., Polansky SM, Feinstein AR. Postmenopausal estrogens protect against fractures of hip and distal radius. Lancet 1979;706- 10.

  39. Weiss NS, Ure CL, Ballard JH, Williams AR, Dailing JR. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogens. N Engl J Med 1980;303:1195–8.

    Google Scholar 

  40. Johnson RE, Specht EE. The risk of hip fracture in postmenopausal females with and without estrogen drug exposure. Am J Public Health 1981;71:138–44.

    Google Scholar 

  41. Kreiger N, Keysley JL, Holford TR, O'Connor T. An epidemiologic study of hip fracture in postmenopausal women. Am J Epidemiol 1982;116:141–8.

    Google Scholar 

  42. Williams AR, Weiss NS, Ure CL, Ballard J, Dailing JR. Effect of weight, smoking, and estrogen use on the risk of hip and forearm fractures in postmenopausal women. Obstet Gynecol 1982;60:695–9.

    Google Scholar 

  43. Kanis JA, Johnell O, Gulberg B, et al. Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture. BMJ 1992;305:1124–8.

    Google Scholar 

  44. Cauley JA, Seeley DG, Ensrud K, Ettinger B, Black D, Cummings SR and Study of Osteoporotic Fractures Research Group. Estrogen replacement therapy and fractures in older women. Ann Intern Med 1994;122:9–16.

    Google Scholar 

  45. Riggs BL, Jowsey J, Kelly PJ, Jones JD, Maher ET. Effect of sex hormones on bone in primary osteoporosis. J Clin Invest 1969;48:1065–72.

    Google Scholar 

  46. Steiniche T, Hasling C, Charles P, Eriksen EF, Mosekilde L, Melsen F. A randomized study on the effects of estrogen/gestagen or high dose oral calcium on trabecular bone remodelling in postmenopausal osteoporosis. Bone 1989;10:313–20.

    Google Scholar 

  47. Holland EFN, Chow JW, Studd JWW, Leather AT, Chambers TJ. Histomorphometric changes in the skeleton of postmenopausal women with low bone mineral density treated with percutaneous estradiol implants. Obstet Gynecol 1994;83:387–91.

    Google Scholar 

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  1. INSERM Research Unit 403, Hôpital Edouard Herriot, Pavilion F, F-69437, Lyon, Cedex 03, France

    P. D. Delmas

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Delmas, P.D. Hormone replacement therapy in the prevention and treatment of osteoporosis. Osteoporosis Int 7 (Suppl 1), 3–7 (1997). https://doi.org/10.1007/BF01674805

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