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Concentration of antibiotics in renal interstitial fluid, soft tissue interstitial fluid, urine and serum

Antibiotikaspiegel in der interstitiellen Flüssigkeit von Subkutangewebe, Niere, Urin und Serum

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Summary

Utilizing multiperforated capsules implanted in tissue, the concentrations of cephalotin, ampicillin, and tetracycline in soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were measured simultaneously and compared with concentrations found in serum and urine in dogs. Antibiotic concentration in RIF was less than urinary levels but exceeded serum concentrations. A direct time-concentration relationship of these three structurally unrelated antibiotics in serum and renal interstitial fluid was found. This model helps illuminate the basic pharmacokinetics of antibiotic in the renal interstitium where pyelonephritis occurs.

Zusammenfassung

Mittels implantierter perforierter Kapseln wurde die Konzentration von Cephalothin, Ampicillin und Tetrazyklin in der interstitiellen Flüssigkeit des Subkutangewebes und der Niere (RIF) gemessen und mit der Konzentration im Serum und Urin verglichen. Die Antibiotikakonzentration im RIF war niedriger als im Urin, überstieg aber die Serumkonzentration. Die drei strukturell unterschiedlichen Antibiotika zeigten eine direkte Zeit-Konzentrationsabhängigkeit. Dieses Modell trägt zum grundsätzlichen Verständnis der Pharmakokinetik im Niereninterstitium bei, in dem sich die Pyelonephritis abspielt.

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Authors and Affiliations

  1. Section on Urology, Department of Surgery, and the Price Institute of Surgical Research, University of Louisville School of Medicine, Health Sciences Center, 40201, Louisville, Kentucky, USA

    H. -U. Eickenberg, L. Scharfenberger &  N. G. Waterman

Authors
  1. H. -U. Eickenberg
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  2. L. Scharfenberger
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  3. N. G. Waterman
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Eickenberg, H.U., Scharfenberger, L. & Waterman, N.G. Concentration of antibiotics in renal interstitial fluid, soft tissue interstitial fluid, urine and serum. Infection 4 (Suppl 2), S97–S104 (1976). https://doi.org/10.1007/BF01674477

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  • DOI: https://doi.org/10.1007/BF01674477

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