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Systemic and local factors and the maintenance of bone quality

  • Session IV
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Summary

Bone formation, an essential process for the maintenance of bone mass and strength, depends on changes in osteoblast number or function. Bone formation is modified by systemic hormones such as parathyroid hormone, growth hormone, insulin and steroids, and by local factors that act in an antocrine or paracrine fashion on the osteoblast. Skeletal cells synthesize platelet-derived growth factors and fibroblast growth factors, agents which affect osteoblast cell replication. In addition, skeletal cells synthesize insulin-like growth factors and transforming growth factors beta, agents which also affect the differentiated function of the osteoblast. Systemic and local factors that modify bone formation are likely critical in the maintenance of normal bone.

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References

  1. Hock JM, Centrella M, Canalis E (1988) Insulin-like growth factor I (IGF-I) has independent effects on bone matrix formation and cell replication. Endocrinology 122:254–260

    Google Scholar 

  2. Civitelli R, Hruska KA, Jeffrey JJ, Kahn AJ, Avioli LV, Partridge NC (1989) Second-messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells. Endocrinology 124:2928–2934

    Google Scholar 

  3. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC (1992) Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88–91

    Google Scholar 

  4. Canalis E, Centrella M, Burch W, McCarthy TL (1989) Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60–65

    Google Scholar 

  5. Selye H (1932) On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol. Endocrinology 16:547–558

    Google Scholar 

  6. Kream BE, LaFrancis D, Petersen DN, Woody C, Clark S, Rowe DW, Lichtler A (1991) Parathyroid hormone represses α1(1) collagen promoter activity in calvariae from neonatal transgenic mice. J Bone Miner Res 6(suppl 1):S135

    Google Scholar 

  7. McCarthy TL, Centrella M, Canalis E (1989) Parathyroid hormone enhances the transcript and polypeptide levels of insulinlike growth factor I in osteoclast-enriched cultures from fetal rat bone. Endocrinology 124:1247–1253

    Google Scholar 

  8. Kaufman J-M, Taelman P, Vermeulen A, Vandeweghe M (1992) Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab 74:118–123

    Google Scholar 

  9. Hock JM, Fonseca J (1990) Anabolic effect of human synthetic parathyroid hormone-(1-34) depends on growth hormone. Endocrinology 127:1804–1810

    Google Scholar 

  10. Canalis E (1980) Effect of insulin-like growth factor I on DNA and protein synthesis in cultured rat calvariae. J Clin Invest 66:709–719

    Google Scholar 

  11. Lukert BP, Raisz LG (1990) Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 112:352–364

    Google Scholar 

  12. Canalis E (1983) Effects of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae. Endocrinology 112:931–939

    Google Scholar 

  13. McCarthy TL, Centrella M, Canalis E (1990) Cortisol inhibits the synthesis of insulin-like growth factor I in skeletal cells. Endocrinology 126:1569–1575

    Google Scholar 

  14. Canalis E, McCarthy TL, Centrella M (1991) Growth factors and cytokines in bone cell metabolism. Annu Rev Med 42:17–24

    Google Scholar 

  15. Barnard JA, Lyons RM, Moses HL (1990) The cell biology of transforming growth factor β. Biochim Biophys Acta 1032:79–87

    Google Scholar 

  16. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (1988) Novel regulators of bone formation: molecular clones and activities. Science 242:1528–1534

    Google Scholar 

  17. Border WA, Ruoslahti E (1992) Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest 90:1–7

    Google Scholar 

  18. Canalis E, Centrella M, McCarthy TL (in press) The role of insulin-like growth factors in bone remodeling. Proceedings of the XIth International Conference on Calcium Regulating Hormones, Florence, Italy

  19. Shimasaki S, Gao L, Shimonaka M, Ling N (1991) Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Mol Endocrinol 5:938–948

    Google Scholar 

  20. LaTour D, Mohan S, Linkhart TA, Baylink DJ, Strong DD (1990) Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. Mol Endocrinol 4:1806–1814

    Google Scholar 

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Authors and Affiliations

  1. Departments of Research, Medicine and Orthopedics, Saint Francis Hospital and Medical Center, 114 Woodland Street, 06105, Hartford, Connecticut

    Ernesto Canalis

  2. University of Connecticut School of Medicine, 06030, Farmington, Connecticut, USA

    Ernesto Canalis

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  1. Ernesto Canalis
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Canalis, E. Systemic and local factors and the maintenance of bone quality. Calcif Tissue Int 53 (Suppl 1), S90–S93 (1993). https://doi.org/10.1007/BF01673411

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  • DOI: https://doi.org/10.1007/BF01673411

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