Abstract
Group I pepsinogen (PG-I) staining was performed in the gastric carcinoma tissues of 75 patients by the peroxidase-antiperoxidase (PAP) method, 44 cases (59%) of which were positive for PG-I, suggesting that they were PG-I-producing gastric carcinomas. Type IV gastric carcinoma by the Borrmann classification and/or poorly-differentiated adenocarcinoma were positive for PG-I in high incidence. Serum and urinary levels of PG-I were determined by the Pepsinogen I Radioimmunoassay Kit in patients with gastric carcinoma who underwent total gastrectomy. The levels of PG-I declined remarkably or disappeared at 1 week after curative surgery. Changes of serum PG-I levels after total gastrectomy were observed in 9 patients with PG-I-producing gastric carcinomas, 7 of whom died of recurrence. The PG-I values became elevated with recurrence in 5 of them and the values increased with the passage of time. In contrast, no substantial changes in PG-I levels occurred in patients with no recurrence. These results suggest that PG-I is useful for the early detection of recurrent disease after total gastrectomy in patients with PG-I-producing gastric carcinomas.
Résumé
Des prélèvements tissulaires de cancer gastrique chez 75 patients one été testés à la recherche de pepsinogène du groupe I (PG-I) par la méthode peroxydase-antiperoxydase. L'examen était positif dans 44 cas (59%), suggérant que ces cancers produisaient le PG-I. Les cancers gastriques du type IV de la classification de Borrmann et/ou les adénocarcinomes peu différenciés produisaient également le PG-I avec une incidence élevée. Le taux de PG-I dans le sérum et dans les urines a été déterminé par la méthode d'immunofluorescence chez les patients ayant subi une gastrectomie totale pour un cancer gastrique. Le taux de PG-I a diminué de façon importante ou a complètement disparu une semaine après l'intervention à visée curative. Des variations sériques de PG-I ont été observées chez 9 patients dont 7 sont morts de récidive. Le taux de PG-I était élevé chez 5 des 7 patients. Par contre, le taux de PG-I n'a jamais varié chez les patients n'ayant pas eu de récidive. Ces résultats suggèrent, dans la surveillance des patients ayant un cancer produisant le PG-I, que le dosage de PG-I est utile pour détecter la récidive.
Resumen
Se realizó la tinción de PG-I en tejidos de carcinoma gástrico de 75 pacientes por el medio de la peroxidasa-antiperoxidasa (PAP); 44 casos (59%) resultaron positivos para PG-I, lo cual sugiere que eran carcinomas gástricos productores de PG-I. Los carcinomas tipo IV de la clasificación de Borrmann y/o los adenocarcinomas pobremente diferenciados fueron positivos para PG-I con una alta frecuencia. Se realizaron determinaciones de los nivelés séricos y urinarios de PG-I por medio del Pepsinogen I Radioimmunoassay Kit en pacientes con carcinoma gástrico sometidos a gastrectomía total. El nivel de PG-I declinó en forma notoria o desapareció a la semana después de efectuada cirugía curativa. Se observaron cambios en los niveles séricos de PG-I después de la gastrectomía total en 9 pacientes con carcinomas gástricos productores de PG-I, 7 de los cuales murieron por recurrencia. Los niveles se elevaron en forma coincidente con la recurrencia en 5 de ellos y se incrementaron con el transcurso del tiempo. Por el contrario, no se observaron cambios sustanciales en los niveles de PG-I en los pacientes libres de recurrencia. Estos resultados sugieren que el PG-I es de utilidad en la detección temprana de enfermedad recurrente después de gastrectomía total en pacientes con carcinomas gástricos productores de PG-I.
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Kodama, M., Koyama, K., Tsuburaya, Y. et al. Group I pepsinogen for early detection of gastric cancer recurrence after total gastrectomy. World J. Surg. 14, 94–99 (1990). https://doi.org/10.1007/BF01670552
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DOI: https://doi.org/10.1007/BF01670552