Zusammenfassung
Die DNA-Gyrase spielt eine wichtige Rolle im bakteriellen Stoffwechsel. Ihre Funktion ist die Einführung von negativen Überspiralen in die DNA. Dadurch wird das Auffalten bestimmter DNA-Abschnitte für das Ablesen der DNA erleichtert. Die Gyrase ist somit an der Replikation und der Transkription beteiligt. Die Hemmung der Gyrase durch 4-Chinolone und die Auswirkungen auf die Struktur der DNA werden dargestellt.
Summary
DNA gyrase is an essential enzyme in bacterial metabolism. Its function is the introduction of negative supercoils into DNA. These favour the unwinding of certain parts of DNA und thus are likely to facilitate processes like replication and transcription. Inhibition of DNA gyrase by quinolones and possible effects on the structure of DNA are reviewed.
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Weißer, J., Wiedemann, B. Hemmung der Gyrase durch 4-Chinolone: Wirkung auf die Struktur der DNA. Infection 14 (Suppl 3), S183–S185 (1986). https://doi.org/10.1007/BF01667839
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DOI: https://doi.org/10.1007/BF01667839