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Progrediente Zytomegalie-Enzephalitis unter erfolgreicher Ganciclovir-Therapie einer Zytomegalie-Retinitis bei einem AIDS-Patienten

Progressive cytomegalovirus-encephalitis during successful therapy of cytomegalovirus-retinitis with ganciclovir in an AIDS-patient

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Summary

We describe a case of an HIV-infected intravenous drug-abuser who died of progressive cytomegalovirus encephalitis despite successful treatment of cytomegalovirus retinitis with ganciclovir. On autopsy, complete remission of retinitis and widespread cytomegalovirus-encephalitis could be demonstrated. Therapeutic failure therefore seems attributable to insufficient CNS-distribution of ganciclovir rather than to ganciclovir-resistant cytomegalovirus strains.

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Abbreviations

CCT:

Craniales Computertomogramm

MRT:

Magnet-Resonanz-Tomogramm

CMV:

Zytomegalie-Virus

KBR:

Komplement-Bindungs-Reaktion

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Authors and Affiliations

  1. Medizinische Klinik der Universität Bonn, Deutschland

    S. Ewig, W. Luster & D. Niese

  2. Pathologisches Institut der Universität Bonn, Deutschland

    E. Bierhoff

  3. Radiologische Klinik der Universität Bonn, Deutschland

    A. Steudel

Authors
  1. S. Ewig
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  2. E. Bierhoff
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  3. W. Luster
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  4. A. Steudel
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  5. D. Niese
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Ewig, S., Bierhoff, E., Luster, W. et al. Progrediente Zytomegalie-Enzephalitis unter erfolgreicher Ganciclovir-Therapie einer Zytomegalie-Retinitis bei einem AIDS-Patienten. Klin Wochenschr 69, 449–453 (1991). https://doi.org/10.1007/BF01666835

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  • DOI: https://doi.org/10.1007/BF01666835

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