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Alloimmunisierung und Transfusionsrefraktärität bei Thrombozytensubstitution

Alloimmunization and refractoriness to platelet transfusion therapy

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Summary

No generally accepted policy for avoiding HLA-alloimmunization has so far been established. However, several studies suggest that singledonor instead of random-donor transfusions, white cell depletion, UV-radiation of blood products or application of cyclosporine to the recipient may avoid or at least delay alloimmunization. With regard to cost effectiveness, it would be essential to identify patients with the highest risk of developing alloimmunization. For the time being, transfusion of crossmatch-compatible HLA-selected single donor platelets should be restricted to alloimmunized patients, refractory to pooled random donor platelets.

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Abbreviations

CCI:

Corrected Count Increment

CM:

Cross Match

EK:

Erythrozytenkonzentrat

KMT:

Knochenmarktransplantation

LCT:

Lymphozyten-Toxizitäts Test

MAIPA:

Monoclonal Antibody Immobilization of Platelet Antigen

PAIFT:

Plättchen-Adhäsions-Immunofluoreszenztest

PRP:

Plättchenreiches Plasma

TK:

Thrombozytenkonzentrat

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik der Heinrich-Heine-Universität Düsseldorf, Deutschland

    Dietmar Söhngen & Wolfgang Schneider

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  1. Dietmar Söhngen
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  2. Wolfgang Schneider
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Söhngen, D., Schneider, W. Alloimmunisierung und Transfusionsrefraktärität bei Thrombozytensubstitution. Klin Wochenschr 69, 419–425 (1991). https://doi.org/10.1007/BF01666826

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  • DOI: https://doi.org/10.1007/BF01666826

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