Abstract
The acridinone derivative 3,4-dihydro-3,3-dimethyl-1(2H)-acridinone (4) has been prepared in a two step fashion and the molecular structure confirmed by X-ray diffraction. Compound4 crystallizes in the space group P2l/n witha=6.022(2),b=21.111(2),c=9.604(2) Å, β=99.97(2)°, andZ=4. The single crystal analysis showed the acridinone tricyclic ring is virtually planar except in the gem-dimethyl position of C(3) which presented a half-chair conformation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Contribution No. 1254 from Instituto de Quimica, UNAM.
Kesten, S.J.; Degnan, M.J.; Hung, J.; McNamara, D.J.; Ortwine, D.F.; Uhlendorf, S.E.; Werbel, L.M.;J. Med. Chem. 1992,35, 3429.
Shutske, G.M.Chem. Abstr. 1993,118, 45771.
Cholody, W.M.; Konopa, J.; Antonini, I.; and Martelli, S.J. Heterocyclic Chem. 1991,28, 209.
Shutske, G.M.; Pierrat, F.A.; Kapples, K.J.; Cornfeldt, M.L.; Szewczak, M.R.; Huger, F.P.; Bores, G.M.; Haroutunian V. and Davis, K.L.U. Med. Chem. 1989,32, 1805.
Kornilov, M.Y.; Turov, A.V.; Mel'nik, M.V.; Gutsulyak, B.M.Zh. Org. Khim. 1979,15, 2226.
Sheldrick, G.M. SHELXTL-PLUS PCUser's Manual; Siemens Analytical X-ray Instruments: Madison, WI., 1990.
Bandoli, G.; Nicolini, M.; Ongaro, A.Powder Diffr. 1991,6, 196.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Martínez, R., Espinosa-Pérez, G. & Brito-Arias, M. Synthesis of 3,4-dihydro-3,3-dimethyl-1(2H)-acridinone. J Chem Crystallogr 25, 201–203 (1995). https://doi.org/10.1007/BF01666107
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01666107