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Current results of human heart transplantation

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Abstract

At Stanford University Medical Center 109 patients have received 114 heart transplants since 1968. The major indication for transplantation has been cardiac failure due to myopathy secondary to coronary arteriosclerosis. Idiopathic cardiomyopathy has been the second greatest indication. The immunosuppressive regimen has consisted of azathioprine, prednisone, and antithymocyte globulin. Overall, 1-year survival is 52% and recent results indicate a 1-year survival rate of 66%. Currently, 44 patients are alive and the longest surviving patient has enjoyed 6.5 post-transplant years.

Résumé

Depuis 1968, on a pratiqué 114 transplantations cardiaques chez 109 patients au Stanford University Medical Center. La défaillance cardiaque secondaire à l'artériosclérose coronarienne a constitué la principale indication de recourir à la transplantation, tandis que les cardiomyopathies idiopathiques se classaient aux deuxième rang. L'immunosuppression a reposé sur l'emploi de l'azathioprine, de la prednisone et des globulines anti-lymphocitaires. La survie d'un an a été de 52% au total, et plus récemment de 66%. Quarante-quatre patients sont actuellement vivants après transplantation et la plus longue survie a été de 6 ans 1/2.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Stanford University School of Medicine, 94305, Stanford, California, USA

    Eugene Dong Jr. M.D. & Norman E. Shumway M.D.

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  1. Eugene Dong Jr. M.D.
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  2. Norman E. Shumway M.D.
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Dong, E., Shumway, N.E. Current results of human heart transplantation. World J. Surg. 1, 157–163 (1977). https://doi.org/10.1007/BF01665071

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  • DOI: https://doi.org/10.1007/BF01665071

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