Summary
In order to study a supposed association between T-cell activation in vivo and HIV-1-antigenemia in HIV-1-infected patients, the detection of p24-antigen in sera was correlated to serum levels of beta-2-microglobulin and C1q-binding immune complexes. Anti-p24-antibodies and the urinary excretion of neopterin were also analysed.
In 24 of 80 patients (30%) p24-antigen could be detected, and in 15 of 59 (25.4%) there was a loss of anti-p24-antibodies. Tests revealed elevated serum levels of beta-2-microglobulin in 58 of 80 patients (72.5%), elevated levels of C1q-binding immune complexes in 15 of 66 (22.7%), and increased excretion of neopterin in 52 of 60 (86.7%). Detection of p24-antigen, loss of antip24-antibodies, serum levels of beta-2-microglobulin, and urinary excretion of neopterin were significantly correlated to advanced stages of HIV-1 infection.
Patients with p24-antigen in the serum showed significantly more frequently elevated serum levels of beta-2-microglobulin and no significant association with increased urinary excretion of neopterin.
Because of the high proportion of patients with elevated serum levels of beta-2-microglobulin and increased excretion of urinary neopterin in the absence of detectable p24-antigen in serum, we could not correlate HIV-1-antigenemia to T-cell activation in vivo.
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Abbreviations
- AIDS:
-
Acquired Immunodeficiency Syndrome
- CD:
-
Cluster of differentiation
- HIV:
-
Human Immunodeficiency Virus
- PHA:
-
Phythämagglutinin
- WR:
-
Walter-Reed-Stadium
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Harrer, T., Wolf, B., Kersten, W. et al. HIV-1-Antigenämie und T-Zell-Aktivierung bei HIV-1-infizierten Patienten. Klin Wochenschr 68, 864–868 (1990). https://doi.org/10.1007/BF01662783
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DOI: https://doi.org/10.1007/BF01662783