Summary
42 men and women with a genital chlamydial infection were randomly treated with a single dose of 200 mg doxycycline daily for ten days or with 200 mg ofloxacin twice a day for nine days. Two weeks after starting treatment 40 patients were able to be reassessed. All 12 men and all seven women treated with doxycycline had clinically improved or healed and had negative cultures forChlamydia trachomatis. Among the patients treated with ofloxacin, all 11 males had improved or healed andC. trachomatis was not reisolated. These data are promising but larger numbers of patients and a longer follow-up are needed in order to confirm the efficacy of ofloxacin for the treatment of genital chlamydial infections.
Zusammenfassung
42 Männer und Frauen mit genitaler Chlamydieninfektion wurden zufallsgemäß entweder zehn Tage lang mit einer Einzeldosis von 200 mg Doxycyclin täglich oder neun Tage lang mit 200 mg Ofloxacin zweimal täglich behandelt. Zwei Wochen nach Behandlungsbeginn konnten 40 der Patienten nachuntersucht werden. Bei allen 12 Männern und sieben Frauen, die Doxycyclin erhalten hatten, war eine klinische Besserung oder Heilung aufgetreten, der kulturelle Nachweis von Chlamydien war negativ. Bei allen mit Ofloxacin behandelten Männern war eine Besserung oder Heilung mit negativenC. trachomatis- Kulturen festzustellen. Diese Daten sind vielversprechend, doch müssen größere Patientengruppen untersucht und längere Zeit nach der Behandlung beobachtet werden, um die Wirksamkeit von Ofloxacin in der Therapie genitaler Chlamydieninfektionen zu belegen.
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Fransen, L., Avonts, D. & Piot, P. Treatment of genital chlamydial infection with ofloxacin. Infection 14 (Suppl 4), S318–S320 (1986). https://doi.org/10.1007/BF01661307
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DOI: https://doi.org/10.1007/BF01661307