Summary
A randomised double blind trial comparing single oral dose therapy with 200 mg and 400 mg of ofloxacin, respectively was conducted at the Bangrak Hospital, Bangkok during the period December 6, 1985 to January 24, 1986. We treated 234 male patients diagnosed as having uncomplicated gonococcal urethritis with ofloxacin. Ofloxacin, at a single dose of 200 mg or 400 mg, was given to each of them. Fourteen patients were excluded for efficacy assessment. There were 223 patients left for safety assessment. The cure rates were 100% in both groups. Among 233 isolates tested, 48.5% were penicillinase producingNeisseria gonorrhoeae. The range of minimum inhibitory concentrations of ofloxacin was 0.008 to 0.063 mg/l. No adverse drug experiences were reported.
Zusammenfassung
Vom 6. Dezember 1985 bis 24. Januar 1986 wurde am Bangrak Hospital Bangkok eine randomisierte Doppelblindstudie durchgeführt, in der die orale Therapie der unkomplizierten Gonorrhoe mit einer Einzeldosis von 200 mg und von 400 mg Ofloxacin verglichen wurde. Behandelt wurden 234 männliche Patienten mit gesicherter Diagnose einer unkomplizierten Gonokokkenurethritis. Die Patienten erhielten entweder 200 mg oder 400 mg Ofloxacin als Einzeldosis verabreicht. Von der Auswertung der Therapieergebnisse wurden 14 Patienten ausgeschlossen. Für die Beurteilung der Sicherheitsparameter standen 223 Patienten zur Verfügung. In beiden Gruppen wurde eine Heilungsrate von 100% erzielt. 48,5% der 233 isolierten Stämme vonNeisseria gonorrhoeae erwiesen sich als Penicillinasebildner. Die minimalen Hemmkonzentrationen von Ofloxacin lagen zwischen 0,008 und 0,063 mg/l. Unerwünschte Arzneimittelwirkungen wurden nicht beobachtet.
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Ariyarit, C., Panikabutra, K., Chitwarakorn, A. et al. Efficacy of ofloxacin in uncomplicated gonorrhoea. Infection 14 (Suppl 4), S311–S313 (1986). https://doi.org/10.1007/BF01661304
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DOI: https://doi.org/10.1007/BF01661304