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Study of the cerebrospinal fluid penetrability of ofloxacin

Liquorgängigkeit von Ofloxacin

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Summary

In patients with different neurological diseases with blood-brain barrier dysfunction subjected to diagnostic CSF-tap, simultaneous determinations of ofloxacin concentrations in serum and in CSF were carried out. The results show that ofloxacin penetrates well into the CSF achieving adequate bactericidal concentrations against most of the common causative pathogens of meningitis.

Zusammenfassung

Bei Patienten mit verschiedenen neurologischen Erkrankungen und Störungen der Blutliquorschranke, wurde im Rahmen diagnostisch erforderlicher Liquorpunktionen eine simultane Bestimmung der Ofloxacinkonzentrationen im Serum und Liquor vorgenommen. Die Ergebnisse lassen auf eine gute Liquorgängigkeit schließen, wobei Ofloxacin-Liquorspiegel erreicht werden, die für eine bakterizide Wirkung gegen die meisten gängigen Meningitiserreger ausreichen dürften.

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Authors and Affiliations

  1. Institut für Bakteriologie und Hygiene, Krankenhaus Nordstadt, D-3000, Hannover

    G. Stübner

  2. Abteilung für Neurologie, Krankenhaus Nordstadt, D-3000, Hannover

    W. Weinrich &  U. Brands

Authors
  1. G. Stübner
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  2. W. Weinrich
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  3. U. Brands
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Stübner, G., Weinrich, W. & Brands, U. Study of the cerebrospinal fluid penetrability of ofloxacin. Infection 14 (Suppl 4), S250–S253 (1986). https://doi.org/10.1007/BF01661285

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  • DOI: https://doi.org/10.1007/BF01661285

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