Summary
Thein vitro activity of ofloxacin (Hoe 280) againstStaphylococcus aureus, some Enterobacteriaceae andPseudomonas spp. is compared with that of gentamicin using the agar dilution method to determine the minimal inhibitory concentration of each agent for the isolates. Ofloxacin and gentamicin were found to have similar activity againstStaphylococcus aureus with an MIC50 of 0.25 mg/l and an MIC90 of 1.0 mg/l. However, ofloxacin appears to be more active against the Enterobacteriaceae than gentamicin with lower MICs for some species of that family. Ofloxacin was found to have an MIC50 value of 0.25 mg/l for the Enterobacteriaceae and an MIC90 of 1.0 mg/l while the MIC90 of gentamicin for the same isolates was 32.0 mg/l. A significant proportion of ourPseudomonas spp. were resistant to gentamicin with an MIC90 of over 16 mg/l and a range of 0.5 mg/l to > 128 mg/l. Ofloxacin had an MIC range of 0.25 to 4.0 mg/l for the same organisms.
Zusammenfassung
Im Agardilutionsverfahren wurden die minimalen Hemmkonzentrationen von Ofloxacin (Hoe 280) und Gentamicin für Stämme vonStaphylococcus aureus, einige Enterobacteriaceae undPseudomonas spp. bestimmt und ein Vergleich derIn-vitro-Aktivitäten der beiden Antibiotika vorgenommen. In ihrer Wirksamkeit gegenS. aureus waren Ofloxacin und Gentamicin gleichwertig, die MHK50 betrug 0,25 mg/l, die MHK90 1,0 mg/l. Gegen Enterobacteriaceae zeigte sich Ofloxacin hingegen dem Gentamicin bei einigen Arten der Familie überlegen. Die MHK50 von Ofloxacin gegen Enterobacteriaceae betrug 0,25 mg/l, die MHK90 1,0 mg/l; die MHK90 von Gentamicin lag hingegen bei einigen Spezies bei 32 mg/l. Ein erheblicher Anteil unserer Isolate vonPseudomonas spp. war gegen Gentamicin resistent, die MHK90 lag über 16 mg/l, der Bereich der MHK-Werte zwischen 0,5 mg/l und 128 mg/l. Der Bereich der MHK-Werte von Ofloxacin für dieselben Isolate lag zwischen 0,25 und 4,0 mg/l.
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Adeyemi-Doro, F.A.B., Rotowa, N.A. Comparison of the in vitro activity of ofloxacin and gentamicin against isolates from hospitalised patients. Infection 14 (Suppl 4), S240–S242 (1986). https://doi.org/10.1007/BF01661281
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DOI: https://doi.org/10.1007/BF01661281