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Aminopenicillins: Concluding remarks

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Summary

This symposium has focused on the bacteriological, pharmacokinetic, therapeutic, and adverse effects of the aminopenicillins. The compounds which are currently being assessed are primarily amoxycillin, ampicillin, bacampicillin, pivampicillin, and talampicillin. The three last mentioned are prodrugs which upon gastrointestinal absorption are rapidly split to yield circulating ampicillin. Pharmacokinetics and side-effects are reasons why one may narrow the selection of most suitable compounds within this group down to three. Ampicillin and amoxycillin are primary choices for parenteral dosage, and amoxycillin and bacampicillin the most suitable for oral therapy.

Aminopenicilline

Dieses Symposium hat die bakteriologischen, pharmakokinetischen und therapeutischen Seiten, sowie die Nebeneffekte der Aminopenicilline hervorgehoben. Die wichtigsten Substanzen, die gegenwärtig verglichen werden müssen, sind besonders Amoxycillin, Ampicillin, Bacampicillin, Pivampicillin und Talampicillin. Die drei letzteren sind Vormedikamente, die während der Absorption im Darm unter Freigabe von gewöhnlichem Ampicillin hydrolysiert werden. Pharmakokinetische Eigenschaften sowie die Rate an Nebenwirkungen sind die Hauptgründe, weswegen die Auswahl der Aminopenicilline gegenwärtig auf einige wenige beschränkt werden muß. Ampicillin und Amoxycillin sind für parenterale Gabe die wichtigste Alternative, während für orale Gabe Amoxycillin und Bacampicillin als Vorzugspräparate in Frage kommen.

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  1. Department of Microbiology, Institute of Pharmacy, PO Box 1108 Blindern, Oslo 3, Norway

    T. Bergan

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Bergan, T. Aminopenicillins: Concluding remarks. Infection 7 (Suppl 5), S507–S512 (1979). https://doi.org/10.1007/BF01659785

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