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Review of side-effects of aminopenicillins

Übersicht über Nebenwirkungen von Aminopenicillinen

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Summary

Side-effects of aminopenicillin therapy are reviewed on the basis of nine comparative studies of ampicillin and bacampicillin, and available literature data from investigations with talampicillin, pivampicillin, bacampicillin and amoxycillin. Diarrhoea is more common with ampicillin than with newer aminopenicillins. Exanthema do not appear more frequently with newer aminopenicillins. The frequency of upper gastrointestinal complaints in association with some of the newer aminopenicillins (amoxycillin, bacampicillin) is not more frequent than with ampicillin. All current evidence speaks in favour of a change from ampicillin to modern aminopenicillins for oral therapy.

Zusammenfassung

Nebenwirkungen der Aminopenicillin-Therapie werden auf der Basis von neuen Vergleichsstudien von Ampicillin und Bacampicillin sowie von verfügbaren Daten aus der Literatur über Untersuchungen mit Talampicillin, Pivampicillin, Bacampicillin und Amoxycillin besprochen. Diarrhöe tritt bei Ampicillin häufiger auf als bei den neueren Aminopenicillinen. Exantheme scheinen bei den neueren Aminopenicillinen nicht häufiger vorzukommen. Die Häufigkeit von Beschwerden von seiten des oberen Gastrointestinaltraktes in Verbindung mit einigen der neueren Aminopenicilline (Amoxycillin, Bacampicillin) ist nicht größer als in Verbindung mit Ampicillin. Alle geläufigen Fakten sprechen für einen Wechsel von Ampicillin auf die modernen Aminopenicilline für die orale Therapie.

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Literature

  1. Hallander, H., Flodström, A., Sjövall, J. Pharmacological and clinical study of bacampicillin in acute peritonsillitis — a comparison with ampicillin. Antimicrob. Ag. Chemother. 11 (1977) 185–190.

    Google Scholar 

  2. Maesen, F. P. V. A pharmacological and clinical comparison of Penglobe (bacampicillin) and ampicillin in chronic bronchitis. Verslag over symposia betreffende luchtweginfecties, Stockholm 1976. Astra Pharmaceutica BV, Holland, 1976, p. 95.

    Google Scholar 

  3. Tuomaala, R. Bacampicillin and ampicillin in general practice: Double-blind comparison in urinary tract infections. In:Siegenthaler, E., Lüthy, R. (eds): Current Chemotherapy, Vol. 1. American Society Microbiology, Washington DC, 1978, p. 207.

    Google Scholar 

  4. Raunio, V., Jokinen, K., Karjalainen, S. Clinical, bacteriological, and pharmacological study of bacampicillin in chronic maxillary sinusitis. In:Williams, J. O., Geddes, A. M. (eds).: Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976, p. 151.

    Google Scholar 

  5. Kaipainen, W. J., Timonen, T., Raunio, V. Clinical study of bacampicllin in urinary tract infections — a comparison with ampicillin. In:Williams, J. O., Geddes, A. M. (eds.).: Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976, p. 131.

    Google Scholar 

  6. Sourander, L., Virtanen, S. Comparison of bacampicillin and ampicillin in urinary tract infections in elderly hospitalized patients. In:Williams, J. O., Geddes, A. M. (eds.).: Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976.

    Google Scholar 

  7. Olsson, O., Henning, C. Clinical study on bacampicillin in otitis media acuta and sinusitis acuta. In:Williams, J. O., Geddes, A. M. (ed.): Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976, p. 145.

    Google Scholar 

  8. Davies, B. I., Maesen, F. P. V., Brombacher, P. J., Sjövall, J. Twice daily dosage of bacampicillin in chronic bronchitis — a double-blind study. Scand. J. Resp. Dis. 59 (1978) 249–256.

    Google Scholar 

  9. Data on file, Astra Läkemedel, Södertälje, 1978.

  10. Jaffe, G., Murphy, J. E., Robinson, O. P. W. A comparative study of talampicillin and ampicillin in general practice. Practitioner 216 (1976) 455–460.

    Google Scholar 

  11. Knudsen, E. T., Harding, J. W. A multicentre comparative trial of talampicillin and ampicillin in general practice. Br. J. Clin. Pract. 29 (1975) 255–265.

    Google Scholar 

  12. Berg, K. J., Widerøe, T.-E. Pivampicillin chloride in the treatment of urinary tract infections in a medical department, Chemotherapy 18 (1973) 130–136.

    Google Scholar 

  13. Brumfitt, W., Franklin, I., Hayek, L., Pursell, R. Treatment of urinary tract infection with pivampicillin. Scand. J. Infect. Dis. 5 (1973) 59–65.

    Google Scholar 

  14. Danø, P., From Hansen, P. Antibiotic treatment with pivampicillin chloride in respiratory and urinary tract infections. Chemotherapy 18 (1973) 63–71.

    Google Scholar 

  15. Delepierre, F. Avantages d'un antibiotique oral a absorption rapide et élevée dans le traitement des maladies infectieuses. Sem. Hop. Thér. 49 (1973) 501–504.

    Google Scholar 

  16. Gaudin, G., Ruef, F., Rudhardt, M., Berthoud, S. La pivampicilline. Praxis 63 (1974) 322–330.

    Google Scholar 

  17. Gorbach, H. C. Klinische Erfahrung mit Pivampicillin zur oralen antibiotischen Behandlung von Infektionen der Atem-, Harn- und Gallenwege. Therapiewoche 23 (1973) 1–16.

    Google Scholar 

  18. Jeppesen, F., Illum, P. Pivampicillin (Pondocillin®) in the treatment of maxillary sinusitis. Acta Otolaryngol. 74 (1972) 375–382.

    Google Scholar 

  19. Jordheim, O. Pivampicillin treatment of urogenital infections in gynaecological patients. Infection 2 (1974) 142–144.

    Google Scholar 

  20. Maesen, F., Buytendijk, H. J., Beeuwkes, H. Clinical experience with pivampicillin in chronic bronchitis. Scand. J. Resp. Dis. 55 (1974) 245–255.

    Google Scholar 

  21. Nilsson, L. B. Långtidsbehandling med pivampicillinklorid. Nord Med. 85 (1971) 1381–1383.

    Google Scholar 

  22. Nilsson, L. B. Klinisk värdering av pivampicillin (pondocillin®) tabletter. Opuscula Medica 21 (1976) 119–120.

    Google Scholar 

  23. Pines, A., Greenfield, J. S. B., Raafat, H., Sreedharan, K. S. A comparison of pivampicillin and ampicillin in exacerbations of chronic bronchitis. Br. J. Dis. Chest 67 (1973) 221–226.

    Google Scholar 

  24. Pines, A., Raafat, H., Sreedharan, K. S., Parker, P. A comparison of pivampicillin and tetracycline in exacerbations of chronic bronchitis. Chemotherapy 20 (1974) 361–369.

    Google Scholar 

  25. Schmidt-Mende, M., Hofstetter, A., Carl, P., Keck, W. Behandlung von Harnwegsinfektionen mit Pivampicillin. Münch. Med. Wschr. 114 (1972) 1659–1663.

    Google Scholar 

  26. Lindhe, B. Å. Jämförande undersökning av terapiformer vid behandling av akuta salpingiter. Läkartidningen 72 (1975) 837–838.

    Google Scholar 

  27. Peromet, M., Schoutens, E., Yourassowsky, E. Traitment des infections urinaires par la Pivampicilline. Ars Medici 2 (1974) 315–321.

    Google Scholar 

  28. Hey, H., Medalen, T. J., Mølstad, O. M., Stokholm, K. A clinical evaluation of the tolerance to pivampicillin tablets. Infection 5 (1977) 22–25.

    Google Scholar 

  29. Stahle, J., Bergström, B., Angelborg, C., Bengtsson, S. Bacampicillin in acute sinusitis. In:Williams, J. O., Geddes, A. M. (eds.).: Chemotherapy Vol. 5, Penicillins and Cephalosporins. Plenum Press, New York, 1976.

    Google Scholar 

  30. Skog, E. Sandström, E., Wallmark, G. Clinical and bacteriological study on bacampicillin in skin and soft tissue infections. In:Williams, J. O., Geddes, A. M. (eds.).: Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976, p. 115.

    Google Scholar 

  31. Ursing, B., Lindroth, M., Kamme, C. Bacampicillin in respiratory tract and urinary tract infections. In:Williams, J. O., Geddes, A. M. (eds).: Chemotherapy Vol. 5, Penicillins and Cephalosporins, Plenum Press, New York, 1976, p. 123.

    Google Scholar 

  32. Maesen, F. P. V., Beeuwkes, H., Davies, B. I., Buytendijk, H. J., Brombacher, P. J., Wessman, J. Bacampicillin in acute exacerbations of chronic bronchitis — a dose/range study. J. Antimicrob. Chemother. 2 (1976) 279–285.

    Google Scholar 

  33. Jeppsson, P.-H., Nylen, O., Jönsson, S., Branefors-Helander, P. Bacampicillin in acute tonsillitis. In:Williams, J. O., Geddes, A. M. (eds.).: Chemotherapy Vol. 5, Penicillins and Cephalosporins. Plenum Press, New York, 1976, p. 137.

    Google Scholar 

  34. Carbon, C., Boussougant, Y., Lamotte-Barillon, S. Etude pharmacologique, clinique et therapeutique de la Bacampicilline. Med. Malad. Infect. 7, 8 (1977) 370–374.

    Google Scholar 

  35. Van Giffen, H.: Resultaten van een multi-centre onderzoek met Penglobe (bacampicillin) bij acute exacerbaties van chronische bronchitis. Verslag over symposia betreffende luftweginfecties, Stockholm 1976. Astra Pharmaceutica BV. Holland, 1976, p. 107.

  36. Sjövall, J. Lower respiratory tract infections treated with bacampicillin. A dose comparison. J. Int. Med. Res. 5 (1977) 313–321.

    Google Scholar 

  37. Maesen, F. R. P., Davies, B. I.: Bacampicillin and amoxycillin in acute exacerbations of chronic bronchitis — a comparative double-blind study. XIII World Congress on Diseases of the Chest, Kyoto, 1978.

  38. Brogden, R. N., Speight, T. M., Avery, G. S. Amoxycillin: A review of its antibacterial and pharmacokinetic properties and therapeutic use. Drugs 9 (1975) 88–140.

    Google Scholar 

  39. Neringer, R., Strömberg, A.: Comparative study of amoxycillin and pivampicillin with regard to side-effects. Manuscript in preparation, 1978.

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  1. Department of Infectious Diseases, University Hospital, S-750, 14 Uppsala, Sweden

    F. Nordbring

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Nordbring, F. Review of side-effects of aminopenicillins. Infection 7 (Suppl 5), S503–S506 (1979). https://doi.org/10.1007/BF01659784

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