Summary
To establish the clinical value of antibiotics, clinical trials are necessary. Both bacteriological and clinical-pharmacological data are helpful when designing a proper clinical trial. The difference between amoxicillin and ampicillin preparations cannot be defined on pharmacokinetic grounds alone. The difference in absorption between ampicillin and either pivampicillin or bacampicillin shows the latter two to be superior.
Zusammenfassung
Um den klinischen Wert von Antibiotika zu beurteilen, sind klinische Versuche nötig. Sowohl bakteriologische als auch klinisch pharmakologische Daten unterstützen die Durchführung einer korrekten klinischen Studie. Der Unterschied zwischen Amoxicillin- und Ampicillin-Präparationen kann nicht auf pharmakokinetischer Basis allein definiert werden. In der Beurteilung der unterschiedlichen Resorption zwischen Ampicillin und Pivampicillin oder Bacampicillin hat sich das letztere als überlegen erwiesen.
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Literature
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Mattie, H., Meenhorst, P.L. Clinical pharmacological evaluation of aminopenicillins. Infection 7 (Suppl 5), S456–S457 (1979). https://doi.org/10.1007/BF01659770
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DOI: https://doi.org/10.1007/BF01659770