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Effects of subinhibitory amounts of ampicillin, amoxycillin and mecillinam on the adhesion of escherichia coli bacteria to human urinary tract epithelial cells: A preliminary study

Wirkung von subinhibitorischen Dosen von Ampicillin, Amoxycillin und Mecillinam auf die Adhäsion von Escherichia coli-Bakterien an menschliche Harntrakt-Epithelzellen: Vorläufige Studie

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Summary

Attachment to mucous surfaces may be a prerequisite for bacteria colonizing these surfaces or invading underlying tissues. Subinhibitory amounts of ampicillin and amoxycillin but not mecillinam decreased the attachment ofEscherichia coli bacteria to human uro-epithelial cells in vitro. No significant synergistic effect on the attachment by the antibiotics was obtained. The present report indicates a new parameter for the study of antibacterial actions of drugs.

Zusammenfassung

Die Fähigkeit, an der Oberfläche von Schleimhäuten zu haften, ist möglicherweise eine Voraussetzung dafür, daß Bakterien diese Oberflächen besiedeln oder in tiefere Gewebsschichten eindringen. Subinhibitorische Dosen von Ampicillin und Amoxycillin, nicht aber von Mecillinam verminderten die Haftfähigkeit vonEscherichia coli-Bakterien auf menschlichen Urothelzellen in vitro. Eine signifikante synergistische Wirkung der Antibiotika auf das Haftvermögen der Bakterien wurde nicht erreicht. Der vorliegende Bericht weist auf einen neuen Parameter zur Untersuchung der antibakteriellen Wirkung von Substanzen hin.

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Authors and Affiliations

  1. Department of Immunology, Institute of Medical Microbiology, Guldhedsgatan 10, S-413, 46 Göteborg, Sweden

    C. Svanborg-Edén &  S. Ahlstedt

  2. Department of Infectious Diseases, Östra sjukhuset, S-416 85, Göteborg, Sweden

    T. Sandberg &  K. Stenqvist

Authors
  1. C. Svanborg-Edén
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  2. T. Sandberg
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  3. K. Stenqvist
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  4. S. Ahlstedt
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Svanborg-Edén, C., Sandberg, T., Stenqvist, K. et al. Effects of subinhibitory amounts of ampicillin, amoxycillin and mecillinam on the adhesion of escherichia coli bacteria to human urinary tract epithelial cells: A preliminary study. Infection 7 (Suppl 5), S452–S455 (1979). https://doi.org/10.1007/BF01659769

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