Summary
Bacampicillin was given as tablets or syrup in doses of 400 mg three times per day for seven days to twelve subjects. Saliva, throat and faecal specimens were taken during fourteen days for cultivation of aerobic and anaerobic bacteria. No changes in the oral, throat and faecal flora were seen in the subjects receiving tablets while there was a decrease in the number of aerobic and anaerobic bacteria in those subjects receiving syrup. No increased resistance to ampicillin were found in the isolated bacterial strains. Bacampicillin was well-tolerated and no gastro-intestinal disturbances were experienced.
Zusammenfassung
Bacampicillin wurde in Tabletten- oder Sirupform in Dosen von 400 mg dreimal täglich für sieben Tage an zwölf Personen verabreicht. Speichel-Rachensekret-und Stuhlproben wurden über einen Zeitraum von vierzehn Tagen abgenommen und kulturell auf aerobe und anaerobe Bakterien untersucht. Bei den Personen, die Tabletten erhielten, waren keine Veränderungen der Mund-, Rachen- und Darmflora zu sehen. Hingegen fand sich bei den Personen, die Sirup erhielten, eine Erniedrigung der Anzahl aerober und anaerober Bakterien. Eine erhöhte Resistenz gegen Ampicillin bei den isolierten Bakterienstämmen wurde nicht festgestellt. Bacampicillin wurde gut vertragen, gastrointestinale Störungen traten nicht auf.
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Heimdahl, A., Nord, C.E. & Weilander, K. Effect of bacampicillin on human mouth, throat and colon flora. Infection 7 (Suppl 5), S446–S451 (1979). https://doi.org/10.1007/BF01659768
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DOI: https://doi.org/10.1007/BF01659768