Summary
Bacampicillin and ampicillin were tested and compared with each other in a model of acute, obstructive pyelonephritis in the rat. The compounds were administered orally at five dose levels ranging from 50 mg/kg to 150 mg/kg. Bacampicillin was found to have a greater therapeutic activity than ampicillin, particulary at the higher doses, indicating that its improved absorption properties make it a therapeutically more effective compound than ampicillin.
Zusammenfassung
Bacampicillin und Ampicillin wurden am Modell der akuten, obstruktiven Pyelonephritis in der Ratte getestet und miteinander verglichen. Die Substanzen wurden oral in fünf Dosen, zwischen 50 und 150 mg/kg, gegeben. Bacampicillin wies eine größere therapeutische Aktivität als Ampicillin auf, insbesondere bei höheren Dosen. Dies zeigt, daß Bacampicillin aufgrund seiner verbesserten Absorptionseigenschaften therapeutisch wirksamer ist.
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Ritzerfeld, W. Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat. Infection 7 (Suppl 5), S443–S445 (1979). https://doi.org/10.1007/BF01659767
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DOI: https://doi.org/10.1007/BF01659767