Abstract
Cancer patients are often at high risk for perioperative complications because of preexisting conditions, the magnitude of surgery, and the use of aggressive multimodality treatment. It is essential to identify risk factors preoperatively, correct any deficits, and monitor organ dysfunction. During the perioperative period prophylaxis and surveillance for cardiopulmonary, hematologic, and septic complications should minimize morbidity and mortality. Finally, nutritional support should be given to malnourished patients undergoing extensive operative procedures.
Résumé
Les patients cancéreux sont souvent à haut risque pour faire une complication périopératoire en raison de leur maladie, l'importance du geste chirurgical, et l'aggresivité d'un traitement multidisciplinaire. Il est essentiel d'identifier en préopératoire les facteurs de risque et de corriger les déficits et de surveiller attentivement, pendant la période périopératoire, les organes particulièrement atteints. Une prophylaxie périopératoire des complications cardiopulmonaires, hématologiques et septiques devrait permettre de minimiser la morbidité et la mortalité. Les patients sous-alimentés devant avoir une intervention majeure, doivent recevoir un soutien nutritionnel.
Resumen
Los pacientes con cáncer con frecuencia tienen alto riesgo de desarrollar complicaciones postoperatorias debido a condiciones clínicas preexistentes, a la magnitud de la cirugía y a la utilización de agresivas terapias multimodales. Aparece esencial identificar preoperatoriamente los factores de riesgo, corregir los déficits existentes y monitorizar la disfunción orgánica. En el periodo preoperatorio la profilaxis y vigilancia de posibles complicaciones cardiopulmonares, hematológicas y sépticas deben minimizar la morbilidad y la mortalidad. Finalmente, se debe proveer soporte nutricional a pacientes desnutridos que vayan a ser sometidos a procedimientos quirúrgicos de gran magnitud.
Similar content being viewed by others
References
Ewer, M.S., Ali, M.K.: Surgical treatment of the cancer patient: preoperative assessment and perioperative medical management. J. Surg. Oncol.44:185, 1990
Labovitz, A.J., Pearson, A.C.: Evaluation of left ventricular diastolic function: clinical relevance and recent doppler echocardiographic insights. Am. Heart J.114:836, 1987
Leppo, J., Plaja, J., Gionet, M., Tumolo, J., Paraskos, J.A., Cutler, B.: Noninvasive evaluation of cardiac risk before elective vascular surgery. J. Am. Coll. Cardiol.9:269, 1987
Lette, J., Waters, D., Lassonde, J., Dubbe, S., Heyn, F., Picord, M., Morin, M.: Post-operative myocardial infarction and cardiac death. Ann. Surg.211:84, 1990
Alexander, H.R., Turnbull, A.D., Salmone, J., Keefe, D.H., Melendez, J.: Upper abdominal cancer surgery in the very elderly. J. Surg. Oncol.47:82, 1991
Von Hoff, D., Layard, M., Basa, P., Davis, H.L., von Hoff, A.L., Rozencweig, M., Muggia, F.M.: Risk factors of doxorubicin-induced congestive heart failure. Ann. Intern. Med.91:710, 1979
Von Hoff, D., Rozencweig, M., Layard, M., Slavik, M., Muggia, F.M.: Daunomycin-induced cardiotoxicity in children and adults: a review of 110 cases. Am. J. Med.62:200, 1977
Bristow, M., Mason, J., Billingham, M., Daniels, J.R.: Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyo-cardial biopsy, and cardiac catheterisation. Ann. Intern. Med.88:168, 1978
Twelves, C.J., Ash, C.M., Miles, D.W., Thomas, D.G., Souhami, R.L.: Activity and toxicity of carboplatin and iproplatin in relapsed high grade glioma. Cancer Chemother. Pharmacol.27:481, 1989
Catane, R., Schwade, J.G., Turrisi, A.T., et al.: Pulmonary toxicity after radiation and bleomycin: a review. Int. J. Radiat. Oncol. Biol. Phys.5:1513, 1979
Goldiner, P.L., Carlon, G.C., Cvitkovic, E., Schweizer, D., Howland, W.S.: Factors influencing postoperative morbidity and mortality in patients treated with bleomycin. B.M.J.1:1664, 1978
Nygaard, K., Smith-Erichsen, N., Hatlevoll, R., Refsum, S.B.: Pulmonary complications after bleomycin, irradiation and surgery for esophageal carcinoma. Cancer41:17, 1978
Aronin, P.A., Mahaley, M.S., Rudnick, S.A., Dudka, L., Donohue, J.F., Selker, R.G., Moore, P.: Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors. N. Engl. J. Med.303:183, 1980
Patel, A.R., Shah, P.C., Rhee, H.L., Sasson, H., Rao, K.P.: Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer38:1542, 1976
Corden, B.J., Fine, R.L., Ozols, R.F., et al.: Clinical pharmacology of high dose cisplatinin. Cancer Chemother. Pharmacol.14:38, 1985
Nixon, D.W., Heymsfield, S.B., Cohen, A.E.: Protein-calorie malnutrition in hospitalised cancer patients. Am. J. Med.68:683, 1980
Copeland, E.M., Daly, J.M., Dudrick, S.J.: Nutrition as an adjunct to cancer treatment in the adult. Cancer Res.37:2451, 1977
McAnena, O.J., Daly, J.M.: Impact of anti-tumor therapy on nutrition. Surg. Clin. North Am.66:1213, 1986
DeWys, W.D., Walters, K.: Abnormalities of taste sensation in cancer patients. Cancer36:1888, 1975
Theologides, A.: Pathogenesis of cachexia in cancer. Cancer29:484, 1972
Lundholm, K., Edstron, S., Ekman, L., Karlberg, I., Scherster, T.: Metabolism in peripheral tissues in cancer patients. Cancer Treat. Rep.65(Suppl. 5):79, 1981
Brennan, M.F.: Cancer, cachexia and rate of whole body lipolysis. Metabolism35:304, 1986
Shaw, J.M., Humberstone, D.M., Wolfe, R.R.: Energy and protein catabolism in sarcoma patients. Ann. Surg.207:283, 1988
Reinhardt, G.F., Myscofski, J.W., Wilkens, D.B., et al.: Incidence and mortality of hypoalbuminemic patients in hospitalised veterans. J. Parenteral Ent. Nutr.4:357, 1980
Windsor, J.A., Hill, G.L.: Weight loss with physiologic impairment-a basic indicator of surgical risk. Ann. Surg.207:290, 1988
Torosian, M.H., Mullen, J.L.: Nutritional assessment. In: Science and Practice of Surgery Series, Vol. 4: Hyperalimentation, M.V. Kaminski, editor. New York, Marcel Dekker, 1985
Daly, J.M., Copeland, E.M., Dudrick, S.J.: Effect of intravenous nutrition on tumor growth and host immunocompetence in malnourished animals. Surgery84:655, 1978
Mullen, J.L., Buzby, G.P., Mathews, D.C., Smale, B.F., Rosato, E.F.: Reduction of operative morbidity and mortality by combined preoperative and postoperative nutritional support. Ann. Surg.192:5:604, 1980
Daly, J.M., Massar, E., Giacco, G., Frazier, O.H., Mountain, C.F., Dudrick, S., Copeland, E.M.: Parenteral nutrition in esophageal cancer patients. Ann. Surg.196:203, 1982
Detsky, A.S., Baker, J.P., O'Rourke, K., Goel, V.: Perioperative parenteral nutrition: a meta-analysis. Ann. Intern. Med.107:195, 1987
Buzby, G.P.: Personal communication
Hill, G.L., Witney, G.B., Christie, P.M., Church, J.M.: Protein status and metabolic expenditure determine the response to intravenous nutrition-a new classification of surgical malnutrition. Br. J. Surg.78:109, 1991
Sagar, R., Harland, P., Shields, R.: Early postoperative feeding with elemental diet. B.M.J.1:293, 1979
Delany, H.M., Carnevale, N., Garvey, J.N.: Jejunostomy by a needle catheter technique. Surgery73:786, 1973
Smith, R.C., Hartemink, R.J., Hollinshead, J.W., Gillett, D.J.: Fine bore jejunostomy feeding following major abdominal surgery: a controlled randomized clinical trial. Br. J. Surg.72:458, 1985
Donaldson, S.S.: Nutritional support as an adjunct to radiation therapy. J. Parenter. Ent. Nutr.8:302, 1984
Mullen, J.L., Buzby, G.P., Gertner, M.H., Stein, T.P., Hargrove, W.C., Oram-Smith, J., Rosato, E.F.: Protein synthesis dynamics in human gastrointestinal malignancies. Surgery87:331, 1980
Burt, M.E., Stein, T.P., Brennan, M.F.: A controlled randomized trial evaluating the effects of enteral and parenteral nutrition on protein metabolism in cancer bearing man. J. Surg. Res.34:303, 1983
Ponsky, J.L., Gauderer, M.W., Stellato, T.A.: Percutaneous endoscopic gastrostomy. Arch. Surg.118:913, 1983
Robinson, D.W.: Surgical problems in the excision and repair of irradiated tissue. Plast. Reconstruct. Surg.55:41, 1975
Luce, E.A.: The irradiated wound. Surg. Clin. North Am.64:821, 1984
Devereux, D.F., Kent, H., Brennan, M.F.: Time dependent effects of adriamycin and x-ray therapy of wound healing in the rat. Cancer45:2805, 1980
Shiu, M.H., Turnbull, A.D., Nori, D., Hajdu, S., Hibris, B.: Control of locally advanced extremity soft tissue sarcomas by function saving resection and brachytherapy. Cancer53:1385, 1984
Arbeit, J.M., Hilaris, B.S., Brennan, M.F.: Wound complications in the multimodality treatment of extremity and superficial truncal sarcomas. J. Clin. Oncol.5:480, 1987
Ormsby, M.V., Hilaris, B.S., Dahatreyuou, N., Brennan, M.F.: Wound complications of adjuvant radiation therapy in patients with soft tissue sarcoma. Ann. Surg.210:93, 1989
Mainous, E.G., Hort, G.B.: Osteoradionecrosis of the mandible. Arch. Otolaryngol.101:173, 1975
Schwartzberg, L.S., Holbert, J.M.: Hemorrhagic and thrombotic abnormalities in patients with cancer. Crit. Care Clin.4:107, 1988
Hagedorn, A.B., Bowie, E.J.W., Elveback, L.R.: Coagulation abnormalities in patients with inoperable lung cancer. Mayo Clin. Proc.49:647, 1974
Buss, D.H., Stuart, J.J., Lipscomb, G.E.: The incidence of thrombotic and hemorrhagic disorders in association with extreme thrombocytosis. Am. J. Hematol.20:365, 1985
Oppenheimer, L., Hyrniuk, W.M., Bishop, A.J.: Thrombocytopenia in severe bacterial infections. J. Surg. Res.20:211, 1976
Brown, C.H., Natelson, E.A., Bradshaw, M.W., Williams, T.W., Alfrey, C.P.: The hemostatic defect produced by carbenicillin. N. Engl. J. Med.291:265, 1974
Rubin, R.N., Kies, M.S., Posch, J.J.: Coagulation profiles in patients with metastatic liver disease. Blood52(Suppl.):193, 1978
Gralnick, H.R., Givelber, H., Abrams, E.: Dysfibrinogenemia associated with hepatoma: increased carbohydrate content of the fibrinogen molecule. N. Engl. J. Med.299:221, 1978
Ansell, J.E., Kumar, R., Deykin, D.: The spectrum of vitamin K deficiency. J.A.M.A.238:40, 1977
Gordan, S.G., Cross, B.A.: A factor X-activating cysteine protease from malignant tissue. J. Clin. Invest.67:1665, 1981
Pineo, G.F., Brain, M.C., Gallus, A.S., Hirsch, J., Hatton, M.W.C., Regoeczi, E.: Tumors, mucus production, and hypercoagulability. Ann. N.Y. Acad. Sci.230:262, 1974
Kasimis, B.S., Spiers, A.S.D.: Thrombotic complications in patients with advanced prostatic cancer treated with chemotherapy. Lancet1:159, 1979
Sack, G.H., Levin, J., Bell, W.R.: Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathological, and therapeutic features. Medicine (Baltimore)56:1, 1977
Bodey, G.P., Jadeja, L., Elting, L.: Pseudomonas bacteremia: retrospective analysis of 410 episodes. Arch. Intern. Med.145:1621, 1985
Lenhard, V., Massen, G., Grosse-Wilde, H.: Effect of blood transfusion on immunoregulatory mononuclear cells in prospective transplant recipients. Transplant. Proc.15:1011, 1983
Smith, M.D., Williams, J.D., Coles, G.A., Salaman, J.R.: The effect of blood transfusion on T-suppressor cells in renal dialysis patients. Transplant. Proc.13:181, 1981
Waymack, J.P., Gallon, L., Barcelli, U., Alexander, J.W.: Effect of blood transfusions on macrophage function in a burned animal model. Curr. Surg.43:305, 1986
Burrows, L., Tartter, P.: Effect of blood transfusion on colonic malignancy recurrence rate. Lancet2:662, 1982
Ota, D., Alvarez, L., Lichtiger, B., Giacco, G., Guinne, V.: Perioperative blood transfusion in patients with colon carcinoma. Transfusion25:392, 1985
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kelly, C.J., Daly, J.M. Perioperative care of the oncology patient. World J. Surg. 17, 199–206 (1993). https://doi.org/10.1007/BF01658927
Issue Date:
DOI: https://doi.org/10.1007/BF01658927