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Underweight patients and the risks of major surgery

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Abstract

The relation between weight loss and the risks of major surgery have been investigated for more than 50 years. It can now be said, with some confidence, that the underweight patient has an increased risk of complications following major surgery. This understanding, however, is based on methods of nutritional assessment that are of limited relevance to hospitalized patients whose malnutrition might be due to sepsis, neoplasia, trauma, or starvation. A consequence is the widespread belief that protein-energy malnutrition (PEM) has been overemphasized as a surgical risk factor, and that the many nonnutritional risk factors ought to be implicated more often. An argument is made for a fresh approach to nutritional assessment in order to better identify the individual patient who, by virtue of PEM, stands an increased risk of a complicated postoperative course. It is suggested that an evaluation of the impact PEM has on vital physiologic function provides a clinically relevant defect to identify and treat and a means of monitoring response to nutritional intervention.

Résumé

Selon plusieurs études de ces 50 dernières années portant sur les rapports entre perte de poids et risques de la chirurgie majeure, on peut dire, avec une certaine confiance, que le risque de complications postopératoires est accru chez le patient dont le poids est au-dessous de la moyenne. Cependant, cette affirmation repose sur des méthodes d'évaluation nutritionnelle qui ont peu de rapport avec la situation le plus souvent rencontrée, qui concerne en fait les patients hospitalisés, dénutris du fait d'un sepsis, d'une néoplasie, d'un traumatisme grave, d'un état de sous-alimentation ou d'une combinaison de ces facteurs. La conséquence en est le sentiment répandu que la dénutrition protéique a été surestimée comme facteur de risque chirurgical et que d'autres facteurs, non nutritionnels, doivent être impliqués plus souvent. On avance des arguments nouveaux pour mieux identifier les patients à risque élevé de complications par leur seul état nutritionnel défaillant. On suggère que les conséquences de cet état de dénutrition sur la physiologie vitale sont cliniquement évidentes et sont suffisantes pour permettre d'identifier les patients à risque et de proposer des moyens pour surveiller les réponses à la correction des problèmes nutiritionnels.

Resumen

La relación entre la pérdida de peso y los riesgos de la cirugía mayor han sido motivo de investigación durante los últimos 50 anos. Actualmente se puede afirmar, con un cierto grado de seguridad, que el paciente con peso menor de lo normal tiene un riesgo aumentado de desarrollar complicaciones después de cirugía mayor. Sin embargo, tal aseveración se fundamenta en métodos de valoración nutricional que son apenas de limitada pertinencia en los pacientes hospitalizados cuya malnutrición puede ser debida a sepsis, neoplasia, trauma y/o ayuno. Una consecuencia de lo anterior es el sentimiento generalizado de que la desnutrición proteica-calórica (DPC) ha recibido énfasis excesivo como factor de riesgo quirúrgico, y de que numerosos factores de carácter no-nutricional deberían ser más comúnmente implicados. Se plantea una argumentación en pro de un enfoque fresco de la valoración nutricional con el objeto de identificar mejor aquellos casos individuales quienes, en virtud de DPC, se hallan en mayor riesgo de una evolución postoperatoria complicada. Se sugiere que una evaluación del impacto de la DPC sobre las funciones fisiológicas vitales provee la posibilidad de identificar y tratar una función fisiológica vital defectuosa y representa un medio de monitorizar la respuesta a la intervención nutricional.

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References

  1. Kudsk, K.A., Sheldon, G.F.: Nutritional assessment. In Surgical Nutrition, J.E. Fisher, editor. Boston, Little, Brown, 1983, pp. 407–420

    Google Scholar 

  2. Dempsey, D.T., Mullen, J.L., Buzby, G.P.: The link between nutritional status and clinical outcome: can nutritional intervention modify it? Am. J. Clin. Nutr.47:352, 1988

    Google Scholar 

  3. Meguid, M.M., Campos, A.C., Hammond, W.G.: Nutritional support in surgical practice. Part II. Am. J. Surg.159:427, 1990

    Google Scholar 

  4. Studley, H.O.: Percentage of weight loss: a basic indicator of surgical risk in patients with chronic peptic ulcer. J.A.M.A.106:458, 1936

    Google Scholar 

  5. Cannon, P.R., Wissler, R.W., Woolridge, R.L., Benditt, E.P.: The relationship of protein deficiency to surgical infection. Ann. Surg.120:514, 1944

    Google Scholar 

  6. Neumann, C.G., Lawlor, G.L., Steihm, E.R., Swendseid, M.E., Newton, C., Herbert, J., Ammann, A.J., Jacob, M.: Immunologic responses in malnourished children. Am. J. Clin. Nutr.28:89, 1975

    Google Scholar 

  7. Seltzer, M.H., Bastidas, J.A., Cooper, D.M., Engler, P., Slocum, B., Fletcher, H.S.: Instant nutritional assessment. J. Parenter. Ent. Nutr.3:157, 1979

    Google Scholar 

  8. Bellantone, R., Doglietto, G.B., Bossola, M., Pacelli, F., Negro, F., Sofo, L., Crucitti, F.: Preoperative parenteral nutrition in the high risk surgical patient. J. Parenter. Ent. Nutr.12:195, 1988

    Google Scholar 

  9. Ching, M., Grossi, C.E., Angers, J., Zurawinsky, H.S., Jham, G., Mills, C.B., Nealon, T.F.: The outcome of surgical treatment as related to the response of the serum albumin level to nutritional support. Surg. Gynecol. Obstet.151:199, 1980

    Google Scholar 

  10. Young, G.A., Hill, G.L.: Assessment of protein-calorie malnutrition in surgical patients from plasma proteins and anthropometric measures. Am. J. Clin. Nutr.31:429, 1978

    Google Scholar 

  11. Yamanaka, H., Nishi, M., Kanemaki, T.: Preoperative nutritional assessment to predict postoperative complications in gastric cancer patients. J. Parenter. Ent. Nutr.13:286, 1989

    Google Scholar 

  12. Buzby, G.P., Foster, J., Rosato, E.F.: Transferrin dynamics in total parenteral nutrition. J. Parenter. Ent. Nutr.3:34, 1979

    Google Scholar 

  13. Pettigrew, R.A.: Identification and assessment of the malnourished patient. Baillieres Clin. Gastroenterol.2:729, 1988

    Google Scholar 

  14. Meakins, J.L., Pietsch, J.B., Rubenick, O., Kelly, R., Rode, H., Gordon, J., MacLean, L.D.: Delayed hypersensitivity: indicator of acquired failure of host defences in sepsis and trauma. Ann. Surg.186:241, 1977

    Google Scholar 

  15. Twomey, P., Ziegler, D., Rombeau, J.: Utility of skin testing in nutritional assessment: a critical review. J. Parenter. Ent. Nutr.6:50, 1982

    Google Scholar 

  16. Chandra, R.K.: 1990 McCollum Award Lecture: Nutrition and immunity: lessons from the past and new insights into the future. Am. J. Clin. Nutr.53:1087, 1991

    Google Scholar 

  17. Mullen, J.L., Buzby, G.P., Waldman, T.F., Gertner, M.H., Hobbs, C.L., Rosato, E.F.: Prediction of operative morbidity and mortality by preoperative nutritional assessment. Surg. Forum30:80, 1979

    Google Scholar 

  18. Buzby, G.P., Mullen, J.L., Matthews, D.C., Hobbs, C.L., Rosato, E.F.: Prognostic nutritional index in gastrointestinal surgery. Am. J. Surg.139:159, 1980

    Google Scholar 

  19. The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N. Engl. J. Med.325:525, 1991

    Google Scholar 

  20. Buzby, G.P.: Introduction. Am. J. Clin. Nutr.47:351, 1988

    Google Scholar 

  21. Buzby, G.P., Knox, L.S., Crosby, L.O.: Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Am. J. Clin. Nutr.47:366, 1988

    Google Scholar 

  22. Baker, J.P., Detsky, S., Wesson, D.E., Wolman, S.L., Stewart, S., Whitewell, J., Langer, B., Jeejeebhoy, K.N.: Nutritional assessment: a comparison of clinical judgement and objective measurements. N. Engl. J. Med.306:969, 1982

    Google Scholar 

  23. Detsky, A.S., Baker, J.P., Mendelson, R.A., Wolman, S.L., Wesson, D.E., Jeejeebhoy, K.N.: Evaluating the accuracy of nutritional assessment techniques applied in hospitalized patients: methodology and comparisons. J. Parenter. Ent. Nutr.8:153, 1984

    Google Scholar 

  24. Jeejeebhoy, K.N., Detsky, A.S., Baker, J.P.: Assessment of nutritional status. J. Parenter. Ent. Nutr.14:193S, 1990

  25. Detsky, A.S., Baker, J.P., O'Rourke, K., Johnston, N., Whitewell, J., Mendelson, R.A., Jeejeebhoy, K.N.: Predicting nutrition associated complications for patients undergoing gastrointestinal surgery. J. Parenter. Ent. Nutr.11:440, 1987

    Google Scholar 

  26. Jelliffe, D.B.: The Assessment of the Nutritional Status of the Community. WHO Monograph 53. Geneva, World Health Organization, 1968

    Google Scholar 

  27. Morgan, D.B., Hill, G.L., Burkinshaw, L.: The assessment of weight loss from a single measurement of body weight: problems and limitations. Am. J. Clin. Nutr.33:2101, 1980

    Google Scholar 

  28. Hall, J.C., O'Quigley, J., Giles, G.R., Appleton, N., Stocks, H.: Upper limb anthropometry: the value of measurement variance studies. Am. J. Clin. Nutr.33:1846, 1980

    Google Scholar 

  29. Jeejeebhoy, K.N., Meguid, M.M.: Assessment of nutritional status in the oncologic patient. Surg. Clin. North Am.66:1077, 1986

    Google Scholar 

  30. Rich, A.J.: The assessment of body composition in clinical conditions. Proc. Nutr. Soc.41:389, 1982

    Google Scholar 

  31. Golden, M.H.N.: Transport proteins as indices of protein status. Am. J. Clin. Nutr.35:1159, 1982

    Google Scholar 

  32. Anonymous. Indicators of surgical risk [editorial]. Lancet2:1422, 1986

  33. Rainey-Macdonald, C.G., Holliday, R.L., Wells, G.A., Donner, A.P.: Validity of a two variable nutritional index for use in selecting candidates for nutritional support. J. Parenter. Ent. Nutr.7:15, 1983

    Google Scholar 

  34. Leite, J.F.M.S., Antunes, C.F., Monteiro, J.C.M.P., Pereira, B.T.V.: Value of nutritional parameters in the prediction of postoperative complications in elective gastrointestinal surgery. Br. J. Surg.74:426, 1987

    Google Scholar 

  35. Hill, G.L.: Malnutrition and surgical risk: guidelines for nutritional therapy. Ann. R. Coll. Surg.69:263, 1987

    Google Scholar 

  36. Pettigrew, R.A., Hill, G.L.: Indicators of surgical risk and clinical judgement. Br. J. Surg.73:47, 1986

    Google Scholar 

  37. Fielding, L.P., Stewart-Brown, S., Dudley, H.A.F.: Surgeon related variables and the clinical trial. Lancet2:778, 1978

    Google Scholar 

  38. Phillips, R.K.S., Hittinger, R., Blesovsky, L., Fry, J.S., Fielding, L.P.: Local recurrence following “curative” surgery for large bowel cancer. 1. The overall picture. Br. J. Surg.71:12, 1984

    Google Scholar 

  39. Pettigrew, R.A., Burns, H.J.G., Carter, D.C.: Evaluating surgical risk: the importance of technical factors in determining outcome. Br. J. Surg.74:791, 1987

    Google Scholar 

  40. McLaren, D.S.: A fesh look at protein-energy malnutrition in the hospitalized patient. Nutrition4:1, 1988

    Google Scholar 

  41. Hill, G.L.: Surgical nutrition: time for some clinical commonsense. Br. J. Surg.75:729, 1988

    Google Scholar 

  42. Hunt, D.R., Rowlands, B.J., Johnson, D.: Hand grip strength: a simple prognostic indicator in surgical patients. J. Parenter. Ent. Nutr.9:701, 1985

    Google Scholar 

  43. Jeejeebhoy, K.N.: Bulk or bounce: the object of nutritional support. J. Parenter. Ent. Nutr.12:539, 1988

    Google Scholar 

  44. Klidjian, A.M., Foster, K.J., Kammerling, R.M., Cooper, A., Karran, S.J.: Relation of anthropometric and dynamometric variables to serious postoperative complications. B.M.J.281:899, 1980

    Google Scholar 

  45. Windsor, J.A., Hill, G.L.: Grip strength: a measure of the extent of protein loss in surgical patients. Br. J. Surg.75:880, 1988

    Google Scholar 

  46. Christie, P.M., Hill, G.L.: Effect of intravenous nutrition on nutrition and function in acute attacks of inflammatory bowel disease. Gastroenterology99:730, 1990

    Google Scholar 

  47. Stokes, M.A., Hill, G.L.: Improvement in physiological function with enteral nutrition. Br. J. Surg.78:758, 1991

    Google Scholar 

  48. Greig, P.D., Jeejeebhoy, K.N.: Muscle funcion testing in the hospitalized patient: implications for starvation and refeeding. IEEE Eng. Med. Biol. MagazineJune:36, 1986

    Google Scholar 

  49. Garibaldi, R.A., Britt, M.R., Coleman, M.L., Reading, J.C., Pace, N.L.: Risk factors for postoperative pneumonia. Am. J. Med.70:677, 1981

    Google Scholar 

  50. Bendixen, H.H., Smith, F.M., Mead, J.: Pattern of ventilation in young adults. J. Appl. Physiol.19:195, 1964

    Google Scholar 

  51. Rosenbaum, S.H., Askanazi, J., Hyman, A.I.: Respiratory patterns in profound nutritional depletion [abstract]. Anaesthesiology51:S366, 1979

    Google Scholar 

  52. Rochester, D.F., Esau, S.A.: Malnutrition and the respiratory system. Chest85:411, 1984

    Google Scholar 

  53. Rochester, D.F., Arora, N.S., Braun, N.M.T.: Maximum contractile force of human diaphragm muscle, determined in vivo. Trans. Am. Clin. Climatol. Assoc.93:200, 1981

    Google Scholar 

  54. Arora, N.S., Rochester, D.F.: Effect of body weight and muscularity on human diaphragm muscle mass, thickness and area. J. Appl. Physiol.52:64, 1982

    Google Scholar 

  55. Schoonover, G.A., Olsen, G.N.: Pulmonary function testing in the preoperative period: a review of the literature. J. Clin. Surg.1:125, 1982

    Google Scholar 

  56. Bartlett, R.H., Gassaniga, A.B., Gerahty, T.R.: Respiratory maneuvers to prevent postoperative pulmonary complications: a critical review. J.A.M.A.224:1017, 1973

    Google Scholar 

  57. Windsor, J.A., Hill, G.L.: Risk factors for postoperative pneumonia: the importance of protein depletion. Ann. Surg.208:209, 1988

    Google Scholar 

  58. Haydock, D.A., Hill, G.L.: Improved wound healing response in surgical patients receiving intravenous nutrition. Br. J. Surg.74:320, 1987

    Google Scholar 

  59. Windsor, J.A., Knight, G.S., Hill, G.L.: Wound healing response in surgical patients; recent food intake is more important than nutritional status. Br. J. Surg.75:135, 1988

    Google Scholar 

  60. MacLean, L.D.: Host resistance in surgical patients. J. Trauma19:297, 1979

    Google Scholar 

  61. Meakins, J.L.: Surgeons, surgery and immunomodulation. Arch. Surg.126:494, 1991

    Google Scholar 

  62. Simon, J.: A Physiological Essay on the Thymus Gland. London, Renshaw, 1845

    Google Scholar 

  63. Chandra, R.K.: Numerical and function deficiency in T helper cells in protein energy malnutrition. Clin. Exp. Immunol.51:126, 1983

    Google Scholar 

  64. Haller, I., Zubler, R.H., Lambert, P.H.: Plasma levels of complements components and complement hemolytic activity in protein-energy malnutrition. Clin. Exp. Immunol.34:248, 1978

    Google Scholar 

  65. Hoffman-Goetz, L., Bell, R.C., Deir, R.: Effect of protein malnutrition and interleukin-1 on in vitro rabbit lymphocyte mitogenesis. Nutr. Res.4:769, 1984

    Google Scholar 

  66. Windsor, J.A., Hill, G.L.: Weight loss with physiologic impairment: a basic indicator of surgical risk. Ann. Surg.207:209, 1988

    Google Scholar 

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Windsor, J.A. Underweight patients and the risks of major surgery. World J. Surg. 17, 165–172 (1993). https://doi.org/10.1007/BF01658922

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