Abstract
It is generally agreed that mucosal ischemia of the gastrointestinal tract is one of the major consequences of the low-flow state, be it due to blood loss, fluid loss, or sepsis. In the present paper, arguments are presented in favor of the hypothesis that stress-induced mucosal injury which tends to occur preferentially in the proximal stomach, duodenum, and terminal ileum results from a mucosal energy deficit severe enough to cause cell death.
Résumé
On admet en général que l'ischémie des muqueuses digestives est une des conséquences les plus importantes des états de bas débit circulatoire, qu'ils soient dus à des pertes de sang ou de liquide ou à des infections. Certains arguments, que nous présentons dans cet article, suggèrent que les lésions muqueuses de stress, qui se développent surtout dans le fundus gastrique, dans le duodénum et dans l'iléon terminal, résultent d'un déficit d'énergie au niveau de la muqueuse, responsable de la mort cellulaire.
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Supported in part by United States Public Health Service Grant No. GM-24514.
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Menguy, R. Role of gastric mucosal energy metabolism in the etiology of stress ulceration. World J. Surg. 5, 175–179 (1981). https://doi.org/10.1007/BF01658282
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DOI: https://doi.org/10.1007/BF01658282