Abstract
Pancreatic excretion of moxalactam was evaluated in a patient with mild pancreatitis and pancreatic fistula, in normal dogs, and in dogs with induced pancreatitis. In the patient, moxalactam was not excreted in the pancreatic fluid, despite adequate blood levels. Similarly, no moxalactam activity was present in the pancreatic fluids of normal animals and animals with experimentally induced pancreatitis. The data suggest that moxalactam does not penetrate into pancreatic fluid in detectable concentrations in the presence or absence of pancreatic inflammation.
These results suggest the need for further study of the use of moxalactam in the treatment of bacterial infections of the pancreas.
Résumé
L'excrétion pancréatique de moxalactam a été étudiée chez un malade atteint d'une pancréatite de moyenne intensité et porteur d'une fistule pancréatique, chez les chiens normaux et les chiens présentant une pancréatite aigue provoquée. Chez le malade le moxalactam ne fut pas excrété bien que la circulation sanguine fut normale. Il en fut de même chez les chiens normaux et chez les chiens malades. Ces données suggèrent que le moxalactam ne pénètre pas dans le suc pancréatique en concentrations décelables et ce en la présence ou en l'absence d'inflammation pancréatique.
Il est donc nécessaire de poursuivre des études plus poussées pour savoir si l'emploi du moxalactam pour traiter les infections bactériennes du pancréas est justifié.
Resumen
La excreción pancreática del moxalactam fue valorada en un paciente con pancreatitis levé y fístula pancreática, en perros normales, y en perros con pancreatitis inducida. En el paciente, no se observó excreción del moxalactam en el jugo pancreático, a pesar de nivelés sanguíneos adecuados. Tampoco se demostró actividad de moxalactam en los líquidos pancreáticos de los animales normales ni de los animales con pancreatitis experimentalmente inducida. Estos resultados sugieren que el moxalactam no penetra a los jugos pancreáticos en concentraciones detectables en presencia o en ausencia de inflamación pancreática.
Los resultados indican la necesidad de estudiar más el uso de moxalactam en el tratamiento de las infecciones bacterianas del páncreas.
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Rubinstein, E., Meissel, D., Klein, E. et al. Effect of pancreatitis on moxalactam excretion in pancreatic fluids of dogs and man. World J. Surg. 12, 411–414 (1988). https://doi.org/10.1007/BF01655688
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DOI: https://doi.org/10.1007/BF01655688