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The role of mammography in the detection of bilateral primary breast cancer

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Abstract

The significance of mammography in the detection of contralateral primary breast cancer was evaluated in 55 patients with bilateral breast disease. Fifteen (65%) of 23 patients in the synchronous group and 16 (50%) of 32 patients in the metachronous group had clinically occult carcinoma in the opposite breast. Excluding the 2 malignancies discovered by prophylactic mastectomy, mammography alone was responsible for the detection of 29 (52.7%) nonpalpable, contralateral breast carcinomas. The whole series of 110 malignant breasts comprised 41 nonpalpable carcinomas, of which 12 were noninvasive [ductal carcinoma in situ (7) and lobular carcinoma in situ (5)] and the remaining 29 were invasive carcinomas, either ductal of various types (25) or lobular (4). With regard to the évaluable axillary nodes, 20 (54.1%) of 37 palpable breast cancers and only 3 (11.5%) of 26 nonpalpable breast carcinomas had positive lymph nodes. The multicentricity rate was particularly high in synchronous tumors (70.6%), and in invasive lobular (73.3%) and noninvasive (75%) carcinomas. The favorable 5- and 10-year survival of patients, both in synchronous and metachronous bilateral primary breast cancer, justify that they be treated with aggressive optimism.

Résumé

La valeur de la mammographie dans le dépistage du cancer mammaire primitif controlatéral a été étudié chez 55 malades qui ont présenté un cancer bilatéral du sein. Quinze des 23 malades (65%) dans le groupe synchrone et seize des 32 malades (50%) dans le groupe métachrone présentaient un cancer cliniquement occulte dans le sein opposé. Exclusion faite de 2 cas de tumeurs malignes découverts par une mammectomie prophylactique la mammographie à elle seule permit de dépister dans le sein opposé 29 (52.7%) cas de cancers impalpables. La série, au total 110 cas de tumeurs malignes, comprenait 41 cancers impalpables dont 12 étaient non invasifs (7 cancers in situ canaliculaires et 5 cancers in situ lobulaires) et 29 étaient invasifs (25 cancers canaliculaires de type variable et 4 cancers lobulaires). En ce qui concerne les ganglions axillaires ils étaient envahis dans 20 (54.1%) des 37 des cancers palpables et 3 (11.5%) des 26 cancers non palpables. Le taux de foyers multiples était particulièrement élevé dans les tumeurs synchrones (70.6%), dans les cancers lobulaires invasifs (73.3%) et dans les cancers non invasifs (75%). Le taux favorable de survie à 5 ans et à 10 ans des malades atteints de cancers du sein, aussi bien dans le groupe synchrone que dans le groupe métachrone justifie de les traiter avec aggressivité et optimisme.

Resumen

La significación de la mamografía en la detección del cáncer mamario primario contralateral fue valorada en 55 pacientes con enfermedad mamaria bilateral. Quince (65%) de 23 pacientes en el grupo con enfermedad síncrona y 16 (50%) de 32 pacientes en el grupo con enfermedad metácrona poseían carcinoma clínicamente oculto en el otro seno. Excluyendo las 2 neoplasias malignas descubiertas en mastectomfa profiláctica, la mamografía de por sí fue responsable de la detección de 29 (52.7%) carcinomas contralaterales no palpables. La totalidad de la serie de 110 neoplasias malignas comprendió 41 carcinomas no palpables, de los cuales 12 fueron no invasivos (7 carcinomas ductales in situ y 5 carcinomas lobulillares in situ) y los 29 restantes fueron carcinomas invasivos, unos ductales de diversos tipos (25) y otros lobulillares (4). En relación con los ganglios axilares valorables, 20 (54.1%) de 37 cánceres palpables y sólo 3 (11.5%) de 26 carcinomas no palpables tenían ganglios linfáticos palpables. La tasa de multicentricidad apareció particularmente alta en los tumores síncronos (70.6%) y en los carcinomas lobulillares invasivos (73.3%) y no invasivos (75%). La supervivencia favorable a 5 y 10 años de los pacientes, tanto en el cáncer primario bilateral síncrono como en el metácrono, justifica que sean tratadas con agresivo optimismo.

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Tinnemans, J.G.M., Wobbes, T., Hendriks, J.H.C.L. et al. The role of mammography in the detection of bilateral primary breast cancer. World J. Surg. 12, 382–387 (1988). https://doi.org/10.1007/BF01655680

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