Skip to main content
SpringerLink
Log in

99mTc(V)-dimercaptosuccinic acid scintigraphy for medullary thyroid carcinoma

  • International Association of Endocrine Surgeons—Manuscripts Presented at the 31st Congress of the International Society of Surgery
  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Ten patients with medullary thyroid carcinoma (MTC) and 2 patients with papillary carcinoma of the thyroid were investigated by scintigraphy using99mTc(V)-dimercaptosuccinic acid [99mTc(V)-DMS], a new radiopharmaceutical agent for imaging MTC. At surgery, a tracer dose of the agent was administered intravenously, and the distribution of the agent was studied in the surgically removed tissues. Among the patients with MTC, 7 had clear scintigraphic images of tumors, 2 had faint images, and 1 patient with a recurrent tumor in a lymph node had no significant image. In 3 patients, mediastinal involvements were clearly demonstrated, and mediastinal dissection confirmed the scintigraphic findings. No significant images were obtained in the patients with papillary carcinoma. The tissue distribution studies of99mTc(V)-DMS revealed specific accumulation of the agent in MTC tissue and low uptake in other tissues. This new scintigraphy for MTC is of great value in deciding the surgical approach and follow-up.

Résumé

Dix malades présentant un cancer médullaire thyroïdien et 2 malades un cancer papillaire ont été soumis à une scintigraphie employant un nouveau radioisotope le99mTc(V)-DMS. Au cours de l'intervention une dose traçante de ce nouvel agent fut injectée par voie intraveineuse pour permettre l'étude de sa répartition au niveau de la pièce opératiore. Parmi les malades atteints de cancer médullaire 7 sur 10 ont présenté des images scintigraphiques patentes, 2 des images estompées cependant qu'un malade qui était porteur d'une récidive au niveau d'un ganglion lymphatique ne présentait pas d'image significative. Chez 3 malades une diffusion médiastinale fut clairement démontrée et la dissection médiastinale vint confirmer les constatations scintigraphiques. En revanche aucune image ne fut observée chez les malades atteints de cancer papillaire. Les études de la distribution tissulaire du99mTC(V)-DMS démontrent une imprégnation spécifique importante du néoplasme médullaire par rapport aux autres tissus. Ce nouvel agent scintigraphique de dépistage du cancer médullaire thyroïdien est d'une grande valeur pour déterminer la conduite opératoire et pour suivre le malade après l'intervention.

Resumen

Diez pacientes con carcinoma medular de tiroides (CMT) y 2 pacientes con carcinoma papilar fueron investigados mediante centelleografía utilizando99mTc(V)-ácido dimercaptosuccínico, un nuevo agente radiofarmacéutico para imágenes de CMT. En el curso de la cirugía se administró una dosis trazadora del agente por vía intravenosa, y su distribución fue estudiada en los tejidos de la resección quirúrgica. Entre los pacientes con CMT, 7 presentaron imágenes claras de centelleografía del tumor, 2 presentaron imágenes débiles, y 1 paciente con tumor recurrente en un ganglio linfático no exhibió imagen de significación. En 3 pacientes la invasión mediastinal pudo ser claramente demostrada, y la disección mediastinal confirmó los hallazgos de la centelleografía. No se obtuvieron imágenes significativas en los pacientes con carcinoma papilar. Los estudios de distribución tisular del99mTc(V)-ADMS revelaron acumulación específica del agente en tejido de CMT y baja captación por otros tejidos. Este nuevo método de centelleografía para CMT es de gran valor para decidir sobre el aproche quirúrgico y para el seguimiento.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wells, S.A., Jr., Ontjes, D.A., Cooper, C.W., Hennessy, J.F., Ellis, G.J., McPherson, H.T., Sabiston, D.C.: The early diagnosis of medullary carcinoma of the thyroid gland in patients with multiple endocrine neoplasia type 2. Ann. Surg.182:362, 1975

    Google Scholar 

  2. Wells, S.A., Jr., Baylin, S.B., Gann, D.S., Farrell, R.E., Dilley, W.G., Preissig, S.H., Linehan, W.M., Cooper, C.W.: Medullary thyroid carcinoma. Relationship of method of diagnosis to pathologic staging. Ann. Surg.188:377, 1978

    Google Scholar 

  3. Ishikawa, N., Hamada, S.: Association of medullary carcinoma of the thyroid with carcinoembryonic antigen. Br. J. Cancer34:111, 1976

    Google Scholar 

  4. Löwhagen, T., Willems, J.S., Lundell, G., Sundblad, R., Granberg, P.-O.: Aspiration biopsy cytology in diagnosis of thyroid cancer. World J. Surg.5:61, 1981

    Google Scholar 

  5. Saad, M.D., Ordonez, N.G., Rashid, R.K., Guido, J.J., Hill, C.S., Hickey, R.C., Samaan, N.A.: Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Medicine63:319, 1984

    Google Scholar 

  6. Kosaki, G., Takai, S., Miyauchi, A., et al: Medullary carcinoma of the thyroid in Japan (in Japanese). Gan no Rinsho24:799, 1978

    Google Scholar 

  7. Wells, S.A., Jr., Baylin, S.B., Leight, G.S., Dale, J.K., Dilley, W.G., Farndon, J.R.: The importance of early diagnosis in patients with hereditary medullary thyroid carcinoma. Ann. Surg.195:595, 1982

    Google Scholar 

  8. Rougier, P., Calmettes, C., Laplanche, A., Travagli, J.P., Lefevre, M., Parmentier, C., Milhaud, G., Tubiana, M.: The values of calcitonin and carcinoembryonic antigen in treatment and management of nonfamilial medullary thyroid carcinoma. Cancer51:855, 1983

    Google Scholar 

  9. Miyauchi, A., Onishi, T., Morimoto, S., Takai, S., Matsuzuka, F., Kuma, K., Maeda, M., Kumahara, Y.: Relation of doubling time of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma. Ann. Surg.199:461, 1984

    Google Scholar 

  10. Saad, M.D., Fritsche, H.A., Samaan, N.A.: Diagnostic and prognostic values of carcinoembryonic antigen in medullary carcinoma of the thyroid. J. Clin. Endocrinol. Metab.58:889, 1984

    Google Scholar 

  11. Ohta, H., Yamamoto, K., Endo, K., Mori, T., Hamanaka, D., Shimazu, A., Ikekubo, K., Makimoto, K., Iida, Y., Konishi, J., Morita, R., Hata, N., Horiuchi, K., Yokoyama, A.: A new imaging agent for medullary carcinoma of the thyroid. J. Nucl. Med.25:323, 1984

    Google Scholar 

  12. Anderson, R.J., Sizemore, G.W., Wakner, H.W., Carney, J.A.: Thyroid scintigram in familial medullary carcinoma of the thyroid gland. Clin. Nucl. Med.3:147, 1978

    Google Scholar 

  13. Johnson, D., Coleman, E., McCook, T.A., Dale, J.K., Wells, S.A., Jr.: Bone and liver images in medullary carcinoma of the thyroid gland. J. Nucl. Med.25:419, 1984

    Google Scholar 

  14. Senga, O., Miyakawa, M., Shirota, H., Makiuchi, M., Yano, K., Miyazawa, M., Takizawa, M.: Comparison of T1-201 chloride and Ga-67 citrate scintigraphy in the diagnosis of thyroid tumor. J. Nucl. Med.23:225, 1982

    Google Scholar 

  15. Parthasarathy, K.L., Shimaoka, K., Bakshi, S.P., Razack, M.S.: Radiotracer uptake in medullary carcinoma of the thyroid. Clin. Nucl. Med.5:45, 1980

    Google Scholar 

  16. Hartshorne, M.F., Kari, R.D., Cawthon, M.A., Hammes, C.S., Howard, W.H., Bunker, S.R.: Multiple imaging techniques demonstrate a medullary carcinoma of the thyroid. Clin. Nucl. Med.8:628, 1983

    Google Scholar 

  17. Rasmusson, B.: Scintigraphic studies in patients with medullary carcinoma of the thyroid. Eur. J. Nucl. Med.7:150, 1982

    Google Scholar 

  18. Shigeno, C., Fukunaga, M., Yamamoto, I., Dokoh, S., Morita, R., Hino, M., Torizuka, K.: Accumulation of Tc-99m phosphorus compounds in medullary carcinoma of the thyroid. Report of two cases. Clin. Nucl. Med.7:297, 1982

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Surgery, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan

    Akira Miyauchi M.D., Keigo Endo M.D., Hitoya Ohta M.D., Kanji Torizuka M.D., Fumio Matsuzuka M.D., Akira Kobayashi M.D., Kanji Kuma M.D. & Masazumi Maeda M.D.

  2. Department of Radiology and Nuclear Medicine, Kyoto University Faculty of Medicine, Kyoto

    Akira Miyauchi M.D., Keigo Endo M.D., Hitoya Ohta M.D., Kanji Torizuka M.D., Fumio Matsuzuka M.D., Akira Kobayashi M.D., Kanji Kuma M.D. & Masazumi Maeda M.D.

  3. Kuma Hospital, Kobe, Japan

    Akira Miyauchi M.D., Keigo Endo M.D., Hitoya Ohta M.D., Kanji Torizuka M.D., Fumio Matsuzuka M.D., Akira Kobayashi M.D., Kanji Kuma M.D. & Masazumi Maeda M.D.

Authors
  1. Akira Miyauchi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keigo Endo M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hitoya Ohta M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kanji Torizuka M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fumio Matsuzuka M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akira Kobayashi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kanji Kuma M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masazumi Maeda M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miyauchi, A., Endo, K., Ohta, H. et al. 99mTc(V)-dimercaptosuccinic acid scintigraphy for medullary thyroid carcinoma. World J. Surg. 10, 640–645 (1986). https://doi.org/10.1007/BF01655544

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01655544

Keywords

Search

Navigation