Skip to main content

Advertisement

Log in

The management of severe hyperthyroidism

  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Either subtotal thyroidectomy or ablation of the gland with131I will lead to a permanent cure of hyperthyroidism. In choosing between these 2 modalities of treatment, several factors should be taken into account, such as the type of goiter, the severity of hyperthyroidism, the size of the gland, age, fitness, and preference of the patient. It is our practice to perform a subtotal thyroidectomy on the young patient with a large gland and severe hyperthyroidism. In the preparation of these patients, thionamides, beta-blockade, and Lugol's iodine are used together until the patient is euthyroid. Preparation with beta-blockade alone led to the only instances of impending storm after surgery in our experience.

Résumé

La thyroïdectome subtotale ou le traitement par l'Iode 131 permettent d'assurer la guérison définitive de l'hyperthyroïdisme. Le choix entre les deux modalités thérapeutiques dépend du type du goître, de la gravité de l'hyperthyroïdie, du volume de la glande, de l'âge et aussi des désirs du malade.

Chez le sujet jeune qui présente un volumineux goitre et une hyperthyroïdie sévère les auteurs donnent leur préférence au traitement chirurgical. Le malade est préparé par l'administration conjointe de thionamides, de béta-bloquants et de solution de Lugol de façon à parvenir à un état d'euthyroïdie. La préparation à l'aide exlusive des bétabloquants est insuffisante; elle a été suivie parfois par un “orage thyroïdien post-opératoire.”

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Waldstein, S.S., Slodki, S.J., Kaganiec, I., Bronsky, D.: A clinical study of thyroid storm. Ann. Intern. Med.52:626, 1960

    Google Scholar 

  2. Bayley, R.H.: Thyroid crisis. Surg. Gynecol. Obstet.59:41, 1934

    Google Scholar 

  3. Foss, H.L., Hunt, H.F., McMillan, R.M.: Pathogenesis of crisis and death in hyperthyroidism. J.A.M.A.113:1090, 1939

    Google Scholar 

  4. Urbanic, R.C., Mazzaferri, E.L.: Thyrotoxic crisis and myxedema coma. Heart Lung7:435, 1978

    Google Scholar 

  5. Buxton, R.W.: The problem of thyroid crisis. Surgery16:748, 1944

    Google Scholar 

  6. Werner, S.C.: Modification of the classification of the eye changes of Graves' disease. J. Clin. Endocrinol. Metab.44:203, 1977

    Google Scholar 

  7. Jones, J.E., Shane, S.R., Flink, E.: Magnesium in hyperthyroidism and hypothyroidism. J. Clin. Invest.45:891, 1966

    Google Scholar 

  8. Heimann, P.: Choice of preoperative treatment of hyperthyroidism. World J. Surg.2:289, 1978

    Google Scholar 

  9. Ingbar, S.H., Woeber, K.A.: Disease of the thyroid. In Harrison's Principles of Internal Medicine, 9th Edition, Issebacher et al., eds., New York, McGraw-Hill, 1980

    Google Scholar 

  10. Nagataki, S., Shizume, K., Nakao, K.: Effects of iodide on thyroidal iodine turnover in hyperthyroid subjects. J. Clin. Endocrinol.30:469, 1970

    Google Scholar 

  11. Zonszein, J., Santangelo, R.P., Mackin, J.F., Lee, T.C., Coffey, R.J., Canary, J.J.: Propranolol therapy in thyrotoxicosis. A review of 84 patients undergoing surgery. Am. J. Med.66:411, 1979

    Google Scholar 

  12. McArthur, J.W., Rawson, R.W., Means, J.H., Cope, O.: Thyrotoxic crisis. J.A.M.A.134:868, 1947

    Google Scholar 

  13. Dobyns, B.M.: Prevention and management of hyperthyroid storm. World. J. Surg.2:293, 1978

    Google Scholar 

  14. Labhart, A.: Thyrotoxicosis in Clinical Endocrinology: Theory and Practice. Berlin-Heidelberg-New York, Springer-Verlag, 1974, p. 177

    Google Scholar 

  15. Werner, S.C.: Prednisone in emergency treatment of malignant exophthalmos. Lancet7:1004, 1966

    Google Scholar 

  16. Blahd, W.H., Hays, M.T.: Graves' disease in the male. Arch. Intern. Med.129:33, 1972

    Google Scholar 

  17. Rothberg, M.P., Shebert, R.T., Levey, G.S., Daroff, R.B.: Propanolol and hyperthyroidism. Reversal of upper motor neuron signs. J.A.M.A.250:1017, 1974

    Google Scholar 

  18. Parker, J.L.W., Lawson, D.H.: Death from thyrotoxicosis. Lancet2:894, 1973

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mieny, C.J., Franz, R.C. & Venter, I.D. The management of severe hyperthyroidism. World J. Surg. 6, 689–695 (1982). https://doi.org/10.1007/BF01655360

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01655360

Keywords

Navigation