Abstract
Anaplastic thyroid carcinomas are relatively rare and have a poor prognosis. In most cases, radical surgical procedures are impossible. Recently, a combination therapy of surgical resection, percutaneous irradiation, and chemotherapy has been described in the literature. After xenotransplantation in athymic nude mice, anaplastic thyroid carcinomas show the same histological features compared to the donors. By passing the tumor over several generations of nude mice, a constant growth rate has been observed. The model allows testing of therapeutic approaches in thyroid carcinoma tissues under in vivo conditions. In 2 different studies with 2 different anaplastic transplants, a statistically significant growth inhibition could be observed using doxorubicin therapy. In one study, combination therapy was performed. The results show no statistically significant difference in the group treated by doxorubicin alone. Further investigations, under in vivo conditions, will show whether a suitable combination therapy for anaplastic thyroid carcinoma can be developed.
Résumé
Les carcinomes anaplasiques thyroïdiens sont relativements rares et ont un mauvais pronostic. Dans la plupart des cas, des interventions chirurgicales radicales sont impossibles a réaliser. Récemment une association de la résection chirurgicale avec l'irradiation percutanée et chimiothérapique a été décrite dans la littérature. Après xénotransplantation chez la souris nue athymique, les carcinomes anaplasiques thyroïdiens montrent les mêmes caractères histologiques en comparaison avec les donneurs. Par passage sur plusieurs générations de souris, un taux de croissance constant a été observé. Ce modèle permet de tester les approches thérapeutiques en conditions in vivo dans le cadre des carcinomes du tissu thyroïdien. Au cours de 2 études différentes avec 2 transplants anaplasiques différentes, une inhibition statistiquement différente de la croissance a pu être observé avec des thérapeutiques utilisant de la doxorubicine. Dans une des études, une association thérapeutique a été réalisée. Ces résultats ne montrent aucune différence significative avec le groupe traité par la doxorubicine seule. De prochaines études montreront si au cours de conditions in vivo un concept convenable d'association thérapeutique peut être développé pour les carcinomes anaplasiques thyroïdiens.
Resumen
Los carcinomas tiroideos anaplásicos son relativamente raros y tienen un mal pronóstico. En la mayoría de los casos, los procedimientos quirúrgicos radicales son imposibles. Recientemente, ha aparecido en la literatura una combinatión terapéutica de resectión quirúrgica, irradiatión percutánea, y quimioterapia. Después de xenotrasplante en ratones atímicos, los carcinomas anaplásicos muestran las mismas características que los tumores donantes. Mediante el paso a través de varias generaciones de ratones, se ha podido observar una tasa constante de crecimiento. El modelo permite probar los enfoques terapéuticos en tejidos carcinomatosos tiroideos en condiciones in vivo. En 2 estudios diferentes con 2 diferentes trasplantes anaplásicos, se pudo observar una inhibición estadísticamente significativa bajo terapia con doxorubicina. En un estudio se utilizó terapia combinada. Los resultados muestran que no hay diferencia significativa con el grupo tratado sólo con doxorubicina. Investigaciones adicionales, bajo condiciones in vivo, demostrarán si habrá de ser posible desarrollar un concepto adecuado de terapia combinada para los carcinomas anaplásicos de tiroides.
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Supported by Deutsche Forschungsgemeinschaft, We 1076 1-1/84.
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Wenisch, H.J.C., Wagner, R.H., Schumm-Draeger, P.M. et al. Cytostatic drug therapy in anaplastic thyroid carcinoma. World J. Surg. 10, 762–768 (1986). https://doi.org/10.1007/BF01655232
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DOI: https://doi.org/10.1007/BF01655232