Abstract
The results of visualization of the islet cell tumors of 25 patients after intravenous administration of two isotope-labeled somatostatin analogs (123I-Tyr3-octreotide and111In-octreotide) are described. The primary tumors, as well as previously often unrecognized distant metastases were visualized in 20 of the 25 patients (80%). Parallel in vitro detection of somatostatin receptors on those tumors that had also been visualized in vivo indicates that the ligand binding to the tumor in vivo indeed represents binding to specific somatostatin receptors. The detection of somatostatin receptors on these tumors in vivo predicted a good suppressive effect of octreotide on hormonal hypersecretion by these tumors. It is an easy, quick, harmless procedure that is valuable for localization of primary endocrine pancreatic tumors and their often radiologically and clinically not yet recognized metastases.
Résumé
Les résultats de la localisation de tumeurs insulaires du pancréas par l'administration intraveineuse de deux analogues marqués de la somatostatine, le 123 I-Tyr3-octréotide et le 11 Inoctréotide, ont été analysés chez 25 patients. Les tumeurs primitives et des métastases, souvent méconnues jusqu'alors, ont été visualisées chez 20 des 25 patients (80%). Parallèlement, la détectionin vitro des récepteurs de la somatostatine des tumeurs ainsi visualiséesin vivo sont en faveur d'une liaison à la tumeurin vivo, spécifique des récepteurs en question. La détection de ces récepteursin vivo était un facteur prédictif d'un effet suppressif sur l'hypersécrétion hormonale des tumeurs. Il s'agit d'un moyen d'investigation facile, rapide et sûr de localiser les tumeurs endocrines primitives du pancréas ainsi que leurs métastases, souvent encore cliniquement et radiologiquement muettes.
Resumen
Presentamos los resultados de la visualización de tumores insulares en 25 pacientes luego de la administración intravenosa de dos análogos de la somatostatina marcados con radioisótopos (123I-Ty3-octreótido y 111 In-octreótido). Los tumores primarios, así como las metástasis distantes, frecuentemente desapercibidas, fueron visualizados en 20 de 25 pacientes (80%). La detección paralelain vitro de receptores de somatostatina en tales tumores, que tambión habían sido visualizadosin vivo, indica que la ligazónin vivo representa ligazón a receptores específicos de somatostatina. La detección de receptores de somatostatina en estos tumoresin vivo predijo un buen efecto supresor del octreótido sobre su hipersecreción hormonal.
El procedimiento es sencillo, rápido, libre de peligro y muy valioso en la localización de los tumores endocrinos primarios del páncreas, así como de sus metástasis, que frecuentemente permanecen ocultas en los exámenes radiológicos y clínicos.
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van Eyck, C.H.J., Braining, H.A., Reubi, J.C. et al. Use of isotope-labeled somatostatin analogs for visualization of islet cell tumors. World J. Surg. 17, 444–447 (1993). https://doi.org/10.1007/BF01655102
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DOI: https://doi.org/10.1007/BF01655102