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The anatomical value of Technetium-Thallium subtraction scanning in detection and location of parathyroid adenomas

Valeur anatomique de la scintigraphie de soustraction des images Technetium-Thallium dans la détection et la localisation des adénomes parathyroïdiens

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Summary

99mTechnetium-201Thallium subtraction scanning was performed in 24 patients with primary (N=5) and secondary (N=19) hyperparathyroidism. The preoperative scintigraphy (N=12) detected 21 of 23 enlarged glands surgically removed and was helpful for detecting abnormal location especially in the mediastinum. Postoperative scanning in patients with recurrent hyperparathyroidism confirmed the excessive growth of the remaining half parathyroid after subtotal parathyroidectomy or a missing fifth parathyroid after total parathyroidectomy and autotransplantation. False negative results were due to tumor hyperplasia. The technique is recommended prior to repeated exploration in patients presenting persistent disease to predict the location of adenomas generally unsuccessfully detected by ultrasonography and computed tomography.

Résumé

La scintigraphie de soustraction des images Technetium-Thallium est réalisée sur 24 patients porteurs d'hyperparathyroïdie primaire dans 5 cas, et d'hyperparathyroïdie secondaire dans 19 cas. La scintigraphie préopératoire (N=12) montre 21 sur les 23 glandes hypertrophiées retrouvées et enlevées chirurgicalement. L'examen est d'une grande utilité dans les localisations anormales et surtout médiastinales. La scintigraphie post-opératoire chez les malades présentant une récidive d'hyperparathyroïdie confirme l'augmentation de volume du fragment parathyroïdien laissé en place après parathyroïdectomie subtotale ou la présence d'une 5e glande méconnue après parathyroïdectomie totale avec auto-transplantation. Les faux négatifs sont dûs aux simples hyperplasies. La technique est recommandée avant les interventions itératives pour hyperparathyroïdie persistante. Elle permet la localisation d'adénomes difficilement repérables à l'ultrasonographie ou au scanner.

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Godlewski, G., Artus, J.C., Granolleras, C. et al. The anatomical value of Technetium-Thallium subtraction scanning in detection and location of parathyroid adenomas. Anat. Clin 6, 281–285 (1984). https://doi.org/10.1007/BF01654460

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